Computational models of populations of bacteria and lytic phage.

Abstract:

:The use of phages to control and reduce numbers of unwanted bacteria can be traced back to the early 1900s, when phages were explored as a tool to treat infections before the wide scale use of antibiotics. Recently, phage therapy has received renewed interest as a method to treat multiresistant bacteria. Phages are also widely used in the food industry to prevent the growth of certain bacteria in foods, and are currently being explored as a tool for use in bioremediation and wastewater treatment. Despite the large body of biological research on phages, relatively little attention has been given to computational modeling of the population dynamics of phage and bacterial interactions. The earliest model was described by Campbell in the 1960s. Subsequent modifications to this model include partial or complete resistance, multiple phage binding sites, and spatial heterogeneity. This review provides a general introduction to modeling of the population dynamics of bacteria and phage. The review introduces the basic model and relevant concepts and evaluates more complex variations of the basic model published to date, including a model of disease epidemics caused by infectious bacteria. Finally, the shortcomings and potential ways to improve the models are discussed.

journal_name

Crit Rev Microbiol

authors

Krysiak-Baltyn K,Martin GJ,Stickland AD,Scales PJ,Gras SL

doi

10.3109/1040841X.2015.1114466

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

942-68

issue

6

eissn

1040-841X

issn

1549-7828

journal_volume

42

pub_type

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