Differentiation of proteins based on characteristic patterns of association and denaturation in solutions of SDS.

abstract：:By incorporating a population number regulating mechanism into the formulation of genic selection involving a pair of alleles (A1 and A2) with respective frequencies x and I-x, it is shown that the change of x in one generation is given by deltax = sx(1-x)/W, in which W is the mean absolute selective value (in Wright'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura M

更新日期：1978-04-01 00:00:00

abstract：:Cholinergic pathways serve important functions in learning and memory processes, and deficits in cholinergic transmission occur in Alzheimer disease (AD). A subset of muscarinic cholinergic receptors are linked to G-proteins that activate phospholipase C, resulting in the liberation of inositol trisphosphate and Ca2+ ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly JF,Furukawa K,Barger SW,Rengen MR,Mark RJ,Blanc EM,Roth GS,Mattson MP

更新日期：1996-06-25 00:00:00

abstract：:Controlling the effects of proactive interference (PI), the deleterious effect of prior mental activity on current memory representations, is believed to be a key function of the prefrontal cortex. This view is supported by neuroimaging evidence for a correlation between the longer reaction times caused by high PI con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feredoes E,Tononi G,Postle BR

更新日期：2006-12-19 00:00:00

abstract：:One of the main differences between bacteria and archaea concerns their membrane composition. Whereas bacterial membranes are made up of glycerol-3-phosphate ester lipids, archaeal membranes are composed of glycerol-1-phosphate ether lipids. Here, we report the construction of a stable hybrid heterochiral membrane thr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caforio A,Siliakus MF,Exterkate M,Jain S,Jumde VR,Andringa RLH,Kengen SWM,Minnaard AJ,Driessen AJM,van der Oost J

更新日期：2018-04-03 00:00:00

abstract：:I describe some recent observations of large-scale structure in the galaxy distribution. The best constraints come from two-dimensional galaxy surveys and studies of angular correlation functions. Results from galaxy redshift surveys are much less precise but are consistent with the angular correlations, provided the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efstathiou G

更新日期：1993-06-01 00:00:00

abstract：:HU, the major DNA binding protein of Escherichia coli, exists in solution as a heterodimer composed of two highly homologous subunits: HU1, encoded by hupB; HU2, encoded by hupA. The purification of the HU protein from hupA- or hupB- bacteria showed that the hupB mutant strains synthesize normal amounts of the HU2 sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnefoy E,Almeida A,Rouviere-Yaniv J

更新日期：1989-10-01 00:00:00

abstract：:Although Wingless (Wg)/Wnt signaling has been implicated in heart development of multiple organisms, conflicting results have been reported regarding the role of Wnt/beta-catenin pathway in cardiac myogenesis: Wg/armadillo signaling promotes heart development in Drosophila, whereas activation of Wnt/beta-catenin signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naito AT,Shiojima I,Akazawa H,Hidaka K,Morisaki T,Kikuchi A,Komuro I

更新日期：2006-12-26 00:00:00

abstract：:Prolonged incubation of NIH 3T3 cells under the growth constraint of confluence results in a persistent impairment of proliferation when the cells are subcultured at low density and a greatly increased probability of neoplastic transformation in assays for transformation. These properties, along with the large accumul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow M,Rubin H

更新日期：1996-09-03 00:00:00

abstract：:The eukaryotic small ribosomal subunit carries only four ribosomal (r) RNA methylated bases, all close to important functional sites. N(7)-methylguanosine (m(7)G) introduced at position 1575 on 18S rRNA by Bud23-Trm112 is at a ridge forming a steric block between P- and E-site tRNAs. Here we report atomic resolution s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Létoquart J,Huvelle E,Wacheul L,Bourgeois G,Zorbas C,Graille M,Heurgué-Hamard V,Lafontaine DL

更新日期：2014-12-23 00:00:00

abstract：:For reasons that are unclear the production of embryonic stem cells from ungulates has proved elusive. Here, we describe induced pluripotent stem cells (iPSC) derived from porcine fetal fibroblasts by lentiviral transduction of 4 human (h) genes, hOCT4, hSOX2, hKLF4, and hc-MYC, the combination commonly used to create...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ezashi T,Telugu BP,Alexenko AP,Sachdev S,Sinha S,Roberts RM

更新日期：2009-07-07 00:00:00

abstract：:The activation of cyclin-dependent kinases (cdks) has been implicated in apoptosis induced by various stimuli. We find that the Fas-induced activation of cdc2 and cdk2 in Jurkat cells is not dependent on protein synthesis, which is shut down very early during apoptosis before caspase-3 activation. Instead, activation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou BB,Li H,Yuan J,Kirschner MW

更新日期：1998-06-09 00:00:00

abstract：:Protein kinase A (PKA) is activated during sympathetic stimulation of the heart and phosphorylates key proteins involved in cardiac Ca(2+) handling, including the L-type Ca(2+) channel (Ca(V)1.2) and phospholamban (PLN). This results in acceleration and amplification of the beat-to-beat changes in cytosolic Ca(2+) in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BW,Brunet S,Gilbert ML,Nichols CB,Su T,Westenbroek RE,Scott JD,Catterall WA,McKnight GS

更新日期：2012-10-16 00:00:00

abstract：:Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the β(2)-adrenergic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanyu R,Wehbi VL,Hayata T,Moriya S,Feinstein TN,Ezura Y,Nagao M,Saita Y,Hemmi H,Notomi T,Nakamoto T,Schipani E,Takeda S,Kaneko K,Kurosawa H,Karsenty G,Kronenberg HM,Vilardaga JP,Noda M

更新日期：2012-05-08 00:00:00

abstract：:P elements, a class of mobile genetic elements that cause hybrid dysgenesis in Drosophila melanogaster, have thus far been shown to occur only in this species. Using whole genome blot analysis, we present evidence which indicates that sequences homologous to D. melanogaster P elements also occur in Drosophila paulisto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniels SB,Strausbaugh LD,Ehrman L,Armstrong R

更新日期：1984-11-01 00:00:00

abstract：:Besides ethanol, acetic acid is produced in naturally fermenting sweet resources and is a significant environmental stress for fruit-breeding Drosophila populations and species. Although not related to the presence of an active alcohol dehydrogenase, adult acetic acid tolerance was found to correlate with ethanol tole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakir M,Peridy O,Capy P,Pla E,David JR

更新日期：1993-04-15 00:00:00

abstract：:Activator of G protein signaling 3 (AGS3), originally identified in a functional screen for mammalian proteins that activate heterotrimeric G protein signaling, is known to be involved in drug-seeking behavior and is up-regulated during cocaine withdrawal in animal models. These observations indicate a potential role ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groves B,Gong Q,Xu Z,Huntsman C,Nguyen C,Li D,Ma D

更新日期：2007-11-13 00:00:00

abstract：:We have studied the effect of the cholinergic agonist carbachol on the spontaneous release of glutamate in cultured rat hippocampal cells. Spontaneous excitatory postsynaptic currents (sEPSCs) through glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type channels were recorded by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bouron A,Reuter H

更新日期：1997-10-28 00:00:00

abstract：:The catalytic generation of chiral ester enolate equivalents from α,β-unsaturated aldehydes with chiral N-hetereocyclic carbene catalysts makes possible highly enantioselective hetero-Diels-Alder reactions. The reactions proceed under simple, mild conditions with both aliphatic and aromatic substituted enals as substr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaeobamrung J,Kozlowski MC,Bode JW

更新日期：2010-11-30 00:00:00

abstract：:The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation of protein translation in longevity. Here we report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azpurua J,Ke Z,Chen IX,Zhang Q,Ermolenko DN,Zhang ZD,Gorbunova V,Seluanov A

更新日期：2013-10-22 00:00:00

abstract：:In most animals, longevity is achieved at the expense of fertility, but queen honey bees do not show this tradeoff. Queens are both long-lived and fertile, whereas workers, derived from the same genome, are both relatively short-lived and normally sterile. It has been suggested, on the basis of results from workers, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corona M,Velarde RA,Remolina S,Moran-Lauter A,Wang Y,Hughes KA,Robinson GE

更新日期：2007-04-24 00:00:00

abstract：:Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer's disease (AD), and changes in blood flow are currently the most reliable indicators of the disease. We previously reported that older APP23 transgenic (tg) mice ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer EP,Ulmann-Schuler A,Staufenbiel M,Krucker T

更新日期：2008-03-04 00:00:00

abstract：:Direct measurements of the intracellular level of lambda repressor have been made by a DNA-filter assay and a radioimmune assay. Transcription of cI, the structural gene for repressor, appears to initiate at two different promoters, prm and pre. Promoter pre is activated during the establishment of lysogeny by the act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reichardt L,Kaiser AD

更新日期：1971-09-01 00:00:00

abstract：:The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of the brain immediately following cardiac arrest has not been systematically investigated. In this study, we performed continuous electroencephalography in rats undergoing experimental cardiac arrest and analyzed change...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borjigin J,Lee U,Liu T,Pal D,Huff S,Klarr D,Sloboda J,Hernandez J,Wang MM,Mashour GA

更新日期：2013-08-27 00:00:00

abstract：:Adhesive P pili of uropathogenic Escherichia coli were not assembled by a strain that lacks the periplasmic disulfide isomerase DsbA. This defect was mostly attributed to the immunoglobulin-like pilus chaperone PapD, which possesses an unusual intrasheet disulfide bond between the last two beta-strands of its CD4-like...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacob-Dubuisson F,Pinkner J,Xu Z,Striker R,Padmanhaban A,Hultgren SJ

更新日期：1994-11-22 00:00:00

abstract：:We describe a procedure for predicting the tertiary folds of alpha-helical proteins from their primary sequences. The central component of the procedure is a method for predicting interhelical contacts that is based on a helix-packing model. Instead of predicting the individual contacts, our method attempts to identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Hou J,Kim SH

更新日期：2002-03-19 00:00:00

abstract：:An homologous in vitro assay for yeast nonsense suppressors was used to examine the effect of the cytoplasmically inherited genetic determinant [psi] on the efficiency of in vitro nonsense suppression. The efficiency of all three types of yeast tRNA-mediated nonsense suppressor (ochre, amber, and UGA) is much greater ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuite MF,Cox BS,McLaughlin CS

更新日期：1983-05-01 00:00:00

abstract：:Measurements of auditory sensitivity in terms of the cochlear potentials were made in young specimens of three species of crocodilians, Caiman crocodilus and Alligator mississipiensis of the subfamily Alligatorinae and Crocodylus acutus of the subfamily Crocodylinae. These species show considerable similarity in their...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wever EG

更新日期：1971-07-01 00:00:00

abstract：:The MARCKS protein is a widely distributed cellular substrate for protein kinase C. It is a myristoylprotein that binds calmodulin and actin in a manner reversible by protein kinase C-dependent phosphorylation. It is also highly expressed in nervous tissue, particularly during development. To evaluate a possible devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stumpo DJ,Bock CB,Tuttle JS,Blackshear PJ

更新日期：1995-02-14 00:00:00

abstract：:A computer code to investigate the equilibrium and stability of a diffuse plasma in three dimensions is described that generalizes earlier work on a sharp free boundary model. Toroidal equilibria of a plasma are determined by considering paths of steepest descent associated with a new version of the variational princi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Betancourt O,Garabedian P

更新日期：1976-04-01 00:00:00

abstract：:DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and thermal denaturati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escudé C,Nguyen CH,Kukreti S,Janin Y,Sun JS,Bisagni E,Garestier T,Hélène C

更新日期：1998-03-31 00:00:00