The influence of site-specificity of single amino acid substitutions on electrophoretic separation of yeast iso-1-cytochrome c.

abstract：:Gene duplication creates a second copy of a gene either in tandem to the ancestral locus or dispersed to another chromosomal location. When the ancestral copy of a dispersed duplicate is lost from the genome, it creates the appearance that the gene was "relocated" from the ancestral locus to the derived location. Gene...

journal_title：Journal of molecular evolution

authors： Hart MLI,Vu BL,Bolden Q,Chen KT,Oakes CL,Zoronjic L,Meisel RP

更新日期：2018-07-01 00:00:00

abstract：:The human S100 gene family encodes the EF-hand superfamily of calcium-binding proteins, with at least 14 family members clustered relatively closely together on chromosome 1q21. We have analyzed the most recently available genomic sequence of the human S100 gene cluster for evidence of tandem gene duplications during ...

journal_title：Journal of molecular evolution

authors： Kulski JK,Lim CP,Dunn DS,Bellgard M

更新日期：2003-04-01 00:00:00

abstract：:Calmodulin is a calcium-binding EF-hand protein that is an activator of many enzymes as well as ion pumps and channels. Due to its multiple targets and its central role in the cell, understanding the evolutionary history of calmodulin genes should provide insights into the origin of genetic complexity in eukaryotes. W...

journal_title：Journal of molecular evolution

authors： Karabinos A,Bhattacharya D

更新日期：2000-08-01 00:00:00

abstract：:The evolutionary relationships of four eukaryotic kingdoms--Animalia, Plantae, Fungi, and Protista--remain unclear. In particular, statistical support for the closeness of animals to fungi rather than to plants is lacking, and a preferred branching order of these and other eukaryotic lineages is still controversial ev...

journal_title：Journal of molecular evolution

authors： Kumar S,Rzhetsky A

更新日期：1996-02-01 00:00:00

abstract：:Bacterial lipoproteins, characterized by the N-terminal N-acyl S-diacylglyceryl Cysteine, are key membrane proteins in bacterial homeostasis. It is generally thought that during the modification lipoprotein precursors are translocated via the Sec-machinery in an unfolded state. The recent discovery of twin-arginine tr...

journal_title：Journal of molecular evolution

authors： Shruthi H,Babu MM,Sankaran K

更新日期：2010-04-01 00:00:00

abstract：:Comparisons of the amino acid compositions of the nitrogenase proteins from different organisms and their correlation with cross-reactivities and taxonomical data suggest an evolution within bacterial genomes rather than within plasmids. Comparisons of the amino acid compositions of nitrogenases and other ATP-ases sho...

journal_title：Journal of molecular evolution

authors： Kleiner D,Littke W,Bender H,Wallenfels K

更新日期：1976-03-29 00:00:00

abstract：:Protamine P1 genes have been sequenced following PCR amplification from 11 mammals representing five major mammalian orders: Rodentia (rat and guinea pig), Carnivora (cat and bear), Proboscidea (elephant), Perissodactyla (horse), and Artiodactyla (camel, deer, elk, moose, and gazelle). The predicted amino acid sequenc...

journal_title：Journal of molecular evolution

authors： Queralt R,Adroer R,Oliva R,Winkfein RJ,Retief JD,Dixon GH

更新日期：1995-06-01 00:00:00

abstract：:The heterotrophic theory of the origin of life is the only proposal available with experimental support. This comes from the ease of prebiotic synthesis under strongly reducing conditions. The prebiotic synthesis of organic compounds by reduction of CO(2) to monomers used by the first organisms would also be considere...

journal_title：Journal of molecular evolution

authors： Lazcano A,Miller SL

更新日期：1999-10-01 00:00:00

abstract：:We present sequences of five novel RNase A superfamily ribonuclease genes of the bullfrog, Rana catesbeiana. All five genes encode ribonucleases that are similar to Onconase, a cytotoxic ribonuclease isolated from oocytes of R. pipiens. With amino acid sequence data from 14 ribonucleases from three Rana species (R. ca...

journal_title：Journal of molecular evolution

authors： Rosenberg HF,Zhang J,Liao YD,Dyer KD

更新日期：2001-07-01 00:00:00

abstract：:Wild-type Escherichia coli utilizes glycerol aerobically through an inducible pathway mediated by an ATP-dependent kinase and a glycerol 3-phosphate dehydrogenase which is a flavoprotein. A mutant, strain ECL424, employing a novel pathway for glycerol utilization was isolated. The novel pathway is mediated by an NAD-l...

journal_title：Journal of molecular evolution

authors： Jin RZ,Tang JC,Lin EC

更新日期：1983-01-01 00:00:00

abstract：:Previous studies have shown that pituitary growth hormone displays an episodic pattern of evolution, with a slow underlying evolutionary rate and occasional sustained bursts of rapid change. The present study establishes that pituitary prolactin shows a similar pattern. During much of tetrapod evolution the sequence o...

journal_title：Journal of molecular evolution

authors： Wallis M

更新日期：2000-05-01 00:00:00

abstract：:Insertions and deletions of entire codons have recently been discovered as a mechanism by which B cells, in addition to conventional base substitution, evolve the antibodies produced by their immunoglobulin genes. These events frequently seem to involve repetitive sequence motifs in the antibody-encoding genes, and it...

journal_title：Journal of molecular evolution

authors： Lantto J,Ohlin M

更新日期：2002-03-01 00:00:00

abstract：:From the cloned mitochondrial DNAs (mtDNAs) isolated from two bisexual species, one Mediterranean, Artemia salina, and one American, Artemia franciscana, and two parthenogenetic (diploid and tetraploid) strains of Artemia parthenogenetica collected in Spain, physical maps have been constructed and compared. They are e...

journal_title：Journal of molecular evolution

authors： Perez ML,Valverde JR,Batuecas B,Amat F,Marco R,Garesse R

更新日期：1994-02-01 00:00:00

abstract：:The major histocompatibility complex (MHC) consists of polymorphic frozen blocks (PFBs) that are linked to form megabase haplotypes. These blocks consist of polymorphic sequences and define regions where recombination appears to be inhibited. We have been able to show, using a highly polymorphic sequence centromeric o...

journal_title：Journal of molecular evolution

authors： Gaudieri S,Leelayuwat C,Tay GK,Townend DC,Dawkins RL

更新日期：1997-07-01 00:00:00

abstract：:A 6.0-kb DNA fragment from Gorilla gorilla including the 5' part of the beta-globin gene and about 4.5 kb of its upstream flanking region was cloned and sequenced. The sequence was compared to the human, chimpanzee, and macaque delta-beta intergenic region. This analysis reveals four tandemly repeated sequences (RS), ...

journal_title：Journal of molecular evolution

authors： Perrin-Pecontal P,Gouy M,Nigon VM,Trabuchet G

更新日期：1992-01-01 00:00:00

abstract：:The core histone genes of Saccharomyces cerevisiae are arranged as duplicate nonallelic sets of specifically paired genes. The identity of structural organization between the duplicated gene pairs would have its simplest evolutionary origin in the duplication of a complete locus in a single event. In such a case, the ...

journal_title：Journal of molecular evolution

authors： Smith MM

更新日期：1987-01-01 00:00:00

abstract：:The internal transcribed spacer region (ITS) of the nuclear rDNA cistron represents the barcoding locus for Fungi. Intragenomic variation of this multicopy gene can interfere with accurate phylogenetic reconstruction of biological entities. We investigated the amount and nature of this variation for the lichenized fun...

journal_title：Journal of molecular evolution

authors： Lücking R,Lawrey JD,Gillevet PM,Sikaroodi M,Dal-Forno M,Berger SA

更新日期：2014-02-01 00:00:00

abstract：:In this study, a new strategy for the selection of aptamers against small-molecule target was established using gold nanoparticles (AuNPs) as the separation matrix and Zinc(II)-Protoporphyrin IX (ZnPPIX) as the target molecule without the immobilization step due to the absorption of ssDNA on AuNPs. The progress of the...

journal_title：Journal of molecular evolution

authors： Li W,Luo Y,Gao T,Yang L,Wang J,Pei R

更新日期：2019-09-01 00:00:00

abstract：:Mutational bias toward expansion or contraction of simple sequence repeats (SSRs) is referred to as directionality of SSR evolution. In this communication, we report the mutational bias exhibited by mononucleotide SSRs occurring in the non-coding regions of several prokaryotic genomes. Our investigations revealed that...

journal_title：Journal of molecular evolution

authors： Kumar P,Nagarajaram HA

更新日期：2012-04-01 00:00:00

abstract：:tRNA with a terminal UCCA-3' forms a structure in which the 3'-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3' region, which places the glycine residue in close proximity to the 3'-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA...

journal_title：Journal of molecular evolution

authors： Tamura K

更新日期：2015-10-01 00:00:00

abstract：:Phospholipid vesicles (liposomes) were subjected to dehydration-hydration cycles in the presence of 6-carboxyfluorescein or salmon sperm DNA. We found that the vesicles fused into multilamellar structures during dehydration with solutes trapped between the lamellae. Upon rehydration the lamellae swelled and formed lar...

journal_title：Journal of molecular evolution

authors： Deamer DW,Barchfeld GL

更新日期：1982-01-01 00:00:00

abstract：:Molecular domestication of a transposable element is defined as its functional recruitment by the host genome. To date, two independent events of molecular domestication of the P transposable element have been described: in the Drosophila obscura species group and in the Drosophila montium species subgroup. These P ne...

journal_title：Journal of molecular evolution

authors： Reiss D,Nouaud D,Ronsseray S,Anxolabéhère D

更新日期：2005-10-01 00:00:00

abstract：:The evolution of ligand specificity underlies many important problems in biology, from the appearance of drug resistant pathogens to the re-engineering of substrate specificity in enzymes. In studying biomolecules, however, the contributions of macromolecular sequence to binding specificity can be obscured by other se...

journal_title：Journal of molecular evolution

authors： Held DM,Greathouse ST,Agrawal A,Burke DH

更新日期：2003-09-01 00:00:00

abstract：:To get deeper insight into the evolution of phosphoenolpyruvate carboxylase we have identified PEPC fragments (about 1,100 bp) of another 12 plants species not yet investigated in this context. The selected plants include one Chlorophyta, two Bryophyta, four Pteridophyta, and five Spermatophyta species. The obtained p...

journal_title：Journal of molecular evolution

authors： Gehrig HH,Heute V,Kluge M

更新日期：1998-01-01 00:00:00

abstract：:The mammalian olfactory system utilizes three large receptor families: the olfactory receptors (ORs) of the main nose and the vomeronasal type-1 and type-2 receptor genes (V1Rs and V2Rs) of the vomeronasal organ. We find that these loci are among the most long interspersed nuclear element (LINE)-dense regions of mamma...

journal_title：Journal of molecular evolution

authors： Kambere MB,Lane RP

更新日期：2009-02-01 00:00:00

abstract：:Amino acid substitution models represent substitution rates among amino acids during the evolution. The models play an important role in analyzing protein sequences, especially inferring phylogenies. The rapid evolution of flaviviruses is expanding the threat in public health. A number of models have been estimated fo...

journal_title：Journal of molecular evolution

authors： Le TK,Vinh LS

更新日期：2020-07-01 00:00:00

abstract：:All modern mammals contain a distinctive, highly repeated (> or = 50,000 members) family of long interspersed repeated DNA called the L1 (LINE 1) family. While the modern L1 families were derived from a common ancestor that predated the mammalian radiation approximately 80 million years ago, most of the members of the...

journal_title：Journal of molecular evolution

authors： Pascale E,Liu C,Valle E,Usdin K,Furano AV

更新日期：1993-01-01 00:00:00

abstract：:The weight-averaged observed/expected dinucleotide frequencies for the sum total of the coding regions of five Toxoplasma genes were compared with the same parameters previously determined for the coding regions of 21 Plasmodium genes. In addition, codon usage in the five Toxoplasma genes was compared with that in the...

journal_title：Journal of molecular evolution

authors： Johnson AM

更新日期：1990-04-01 00:00:00

abstract：:In vitro selection of Zn(2+)-dependent RNA-cleaving DNAzymes with activity at 90 degrees C has yielded a diverse spool of selected sequences. The RNA cleavage efficiency was found in all cases to be specific for Zn(2+) over Pb(2+), Ca(2+), Cd(2+), Co(2+), Hg(2+), and Mg(2+). The Zn(2+)-dependent activity assay of the ...

journal_title：Journal of molecular evolution

authors： Nelson KE,Bruesehoff PJ,Lu Y

更新日期：2005-08-01 00:00:00

abstract：:The trnT-trnF region is located in the large single-copy region of the chloroplast genome. It consists of the trnL intron, a group I intron, and the trnT-trnL and trnL-trnF intergenic spacers. We analyzed the evolution of the region in the three genera of the gymnosperm lineage Gnetales (Gnetum, Welwitschia, and Ephed...

journal_title：Journal of molecular evolution

authors： Won H,Renner SS

更新日期：2005-10-01 00:00:00