Abstract：
:Mutational bias toward expansion or contraction of simple sequence repeats (SSRs) is referred to as directionality of SSR evolution. In this communication, we report the mutational bias exhibited by mononucleotide SSRs occurring in the non-coding regions of several prokaryotic genomes. Our investigations revealed that the strains or species lacking mismatch repair (MMR) system generally show higher number of polymorphic SSRs than those species/strains having MMR system. An exception to this observation was seen in the mycobacterial genomes that are MMR deficient where only a few SSR tracts were seen with mutations. This low incidence of SSR mutations even in the MMR-deficient background could be attributed to the high fidelity of the DNA polymerases as a consequence of high generation time of the mycobacteria. MMR system-deficient species generally did not show any bias toward mononucleotide SSR expansions or contractions indicating a neutral evolution of SSRs in these species. The MMR-proficient species in which the observed mutations correspond to secondary mutations showed bias toward contraction of polymononucleotide tracts, perhaps, indicating low efficiency of MMR system to repair SSR-induced slippage errors on template strands. This bias toward deletion in the mononucleotide SSR tracts might be a probable reason behind scarcity for long poly A|T and G|C tracts in prokaryotic systems which are mostly MMR proficient. In conclusion, our study clearly demonstrates mutational dynamics of SSRs in relation to the presence/absence of MMR system in the prokaryotic system.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Kumar P,Nagarajaram HAdoi
10.1007/s00239-012-9491-6subject
Has Abstractpub_date
2012-04-01 00:00:00pages
127-39issue
3-4eissn
0022-2844issn
1432-1432journal_volume
74pub_type
杂志文章abstract：:Phylogenetic relationships of 25 mammalian species representing 17 of the 18 eutherian orders were examined using DNA sequences from a 1.2-kb region of the 5' end of exon 1 of the single-copy nuclear gene known as interphotoreceptor retinoid binding protein (IRBP). A wide variety of methods of analysis of the DNA sequ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2002-05-01 00:00:00
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2008-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00239-008-9105-5
更新日期：2008-08-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 评论,杂志文章
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pub_type： 杂志文章
doi：10.1007/s00239-012-9504-5
更新日期：2012-06-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006450
更新日期：1999-02-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：2004-07-01 00:00:00
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
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