Abstract：
:Simple sequence repeats (SSRs) in DNA sequences are tandem iterations of a single nucleotide or a short oligonucleotide. SSRs are subject to slipped-strand mutations and a common source of phase variation in bacteria and antigenic variation in pathogens. Significantly long SSRs are generally rare in prokaryotic genomes, and long SSRs composed of iterations of mono-, di-, tri-, and tetranucleotides are mostly restricted to host-adapted pathogens. We present new results concerning associations between long SSRs and genes related to different cellular functions in genomes of host-adapted pathogens. We found that in the majority of the analyzed genomes, at least some of the genes associated with SSRs encode potential antigens, which is expected if the primary function of SSRs is their contribution to antigenic variation. However, we also found a number of long SSRs associated with housekeeping genes, including rRNA and tRNA genes, genes encoding ribosomal proteins, amino acyl-tRNA synthetases, chaperones, and important metabolic enzymes. Many of these genes are probably essential and it is unlikely that they are phase-variable. Few statistically significant associations between SSRs and gene functional classifications were detected, suggesting that most long SSRs are not related to a particular cellular function or process. Long SSRs in Mycobacterium leprae are mostly associated with pseudogenes and may be contributing to gene loss following the adaptation to an obligate pathogenic lifestyle. We speculate that LSSRs may have played a similar role in genome reduction of other host-adapted pathogens.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Guo X,Mrázek Jdoi
10.1007/s00239-008-9166-5subject
Has Abstractpub_date
2008-11-01 00:00:00pages
497-509issue
5eissn
0022-2844issn
1432-1432journal_volume
67pub_type
杂志文章abstract：:The mitochondrial genome of yeast (S. cerevisiae or S. carlsbergensis) appears to be formed by 60-70 genetic units, each one of which is formed by (1) a GC-rich sequence, possibly having a regulatory role; (2) a gene, and (3) an AT-rich spacer, which probably is not transcribed. Recombination in this genome appears to...
journal_title：Journal of molecular evolution
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doi：10.1007/BF01796120
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journal_title：Journal of molecular evolution
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doi：10.1007/BF02106178
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-004-0324-0
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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doi：10.1007/s00239-008-9069-5
更新日期：2008-02-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01733261
更新日期：1978-12-29 00:00:00
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journal_title：Journal of molecular evolution
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doi：10.1007/pl00000066
更新日期：1997-01-01 00:00:00
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更新日期：2019-07-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006368
更新日期：1998-08-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01739101
更新日期：1976-08-03 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s002390010188
更新日期：2001-07-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006460
更新日期：1999-02-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02338832
更新日期：1996-09-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-003-2543-1
更新日期：2004-03-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02111286
更新日期：1987-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-003-2533-3
更新日期：2003-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-004-0201-x
更新日期：2005-03-01 00:00:00
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journal_title：Journal of molecular evolution
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doi：10.1007/s00239-003-2563-x
更新日期：2004-04-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006406
更新日期：1998-11-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s002390010148
更新日期：2001-02-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-005-0076-5
更新日期：2006-03-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：1983-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01751807
更新日期：1977-11-25 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：2008-06-01 00:00:00
abstract：:DNA clones have been isolated that span the complete mitochondrial (mt) genome of the dolphin, Cephalorhynchus commersonii. Hybridization experiments with purified primate mtDNA probes have established that there is close resemblance in the general organization of the dolphin mt genome and the terrestrial mammalian mt...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02143495
更新日期：1988-12-01 00:00:00
abstract：:RNA polymerase III promoter is located within the coding region in all eukaryotic tRNA genes, whereas in prokaryotic tRNA genes, the promoter is located upstream of the transcription initiation site. We analyzed the nucleotide sequence context of the A and B boxes of RNA polymerase III promoters from different unicell...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-003-2504-8
更新日期：2003-11-01 00:00:00
