Thermodynamics of peptide bond formation at clay mineral surfaces.

Abstract:

:The possibility of surface catalysed condensation of unsubstituted amino acids on kaolinite in aqueous systems at elevated temperatures was investigated; no evidence of clay catalysed polycondensation has been found. The thermodynamic feasibility of the hypothetical lysine/dilysine condensation reaction in the temperature-range up to 90 degrees C was evaluated for a range of experimental conditions by the combination of measured free energies of lysine/dilysine cation exchange on kaolinite and on montmorillonite, and free energies for the analogous condensation reaction in homogeneous solution. The results indicate that, in spite of the high selectivity of the clays for the adsorption of cation dimers from dilute solutions, the thermodynamic barrier to the surface condensation of unsubstituted amino acids on clay minerals in aqueous systems up to 90 degrees C is not lower than it is in homogeneous solution.

journal_name

J Mol Evol

authors

Flegmann AW,Scholefield D

doi

10.1007/BF01733261

subject

Has Abstract

pub_date

1978-12-29 00:00:00

pages

101-12

issue

2

eissn

0022-2844

issn

1432-1432

journal_volume

12

pub_type

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