Abstract：
:The LMP7 and PSMB5 genes were created through an ancient gene duplication event of their ancestral locus. These proteins contain an active site of proteolysis, and LMP7 replaces PSMB5 as a component of the 20S proteasome after stimulation of cells by interferon-gamma. Replacement of PSMB5 by LMP7 changes the profile of the products of 20S proteasome processing, predisposing digested peptides for transport to and display by the immune system. The purpose of this study is to investigate evolutionary forces influencing functional divergence between LMP7 and PSMB5 following duplication. Levels of synonymous and nonsynonymous substitution rates are estimated to infer differences in levels of natural selection. Estimates of substitution rates indicate that natural selection elevated rates of nonsynonymous substitution in LMP7 following gene duplication, whereas PSMB5 experienced an increase in substitution rate that was not likely due to diversifying natural selection following duplication. Following initial divergence, nearly neutral mutations have dominated gene evolution in both lineages. The LMP7 gene locus provides a rare example of a protein with specialized function arising from duplication and divergence of a housekeeping protein by way of natural selection.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Bos DHdoi
10.1007/s00239-004-0120-xkeywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
221-8issue
2eissn
0022-2844issn
1432-1432journal_volume
60pub_type
杂志文章abstract：:Skin pigmentation is a complex, conspicuous, highly variable human trait that exhibits a remarkable correlation with latitude. The evolutionary history and genetic basis of skin color variation has been the subject of intense research in the last years. This article reviews the major hypotheses explaining skin color d...
journal_title：Journal of molecular evolution
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-008-9189-y
更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1997-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00000066
更新日期：1997-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s002399910042
更新日期：2000-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02101639
更新日期：1983-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00239-008-9098-0
更新日期：2008-05-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-019-09894-4
更新日期：2019-07-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02103135
更新日期：1991-11-01 00:00:00
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更新日期：1993-07-01 00:00:00
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更新日期：2005-09-01 00:00:00
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更新日期：2018-06-01 00:00:00
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