Formation of nucleoside 5'-phosphoramidates under potentially prebiological conditions.

Abstract:

:Adenosine 5'-phosphoramidates form when solutions containing adenosine 5'-polyphosphates pnA (n greater than or equal to 3) or P1, P2-diadenosine 5'-diphosphate and amines are allowed to dry out. Mg ions catalyze these reactions. We have studied systems containing ammonia, imidazole, glycine, ethylenediamine and histamine. The yields of adenosine 5'-phosphoramidates range from 10-50% based on the nucleotide. The prebiotic significance of the reactions is discussed.

journal_name

J Mol Evol

authors

Lohrmann R

doi

10.1007/BF01751807

subject

Has Abstract

pub_date

1977-11-25 00:00:00

pages

137-54

issue

2

eissn

0022-2844

issn

1432-1432

journal_volume

10

pub_type

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