Kinetics of synonymous codon change for an amino acid of arbitrary degeneracy.

Abstract:

:The kinetics of synonymous codon change and species divergence is described in a matrix formalism that is equally applicable to all levels of codon degeneracy and all levels of codon or nucleotide bias. Based on the formalism it is possible to calculate the sum of all synonymous substitution rate constants from the observed sequence differences between two species. This sum, the relaxation rate, is equivalent to the Log Det transformation that has recently been proposed as a new measure of evolutionary distance (Lockhardt et al. Mol. Biol. Evol. 11(4):605-612, 1994). The relationship between this measure and the average number of base changes per site (Ks) is discussed. The formalism is tested on some sets of simulated sequence divergence data.

journal_name

J Mol Evol

authors

Berg OG

doi

10.1007/BF00186546

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

345-52

issue

3

eissn

0022-2844

issn

1432-1432

journal_volume

41

pub_type

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