Abstract:
:Fimbrial adhesins allow bacteria to interact with and attach to their environment. The bacteria possibly benefit from these interactions, but all external structures including adhesins also allow bacteria to be identified by other organisms. Thus adhesion molecules might be under multiple forms of selection including selection to constrain functional interactions or evolve novel epitopes to avoid recognition. We address these issues by studying genetic diversity in the Escherichia coli type-1 fimbrial major subunit, fimA. Overall, sequence diversity in fimA is high (pi = 0.07) relative to that in other E. coli genes. High diversity is a function of positive diversifying selection, as detected by d(N)/d(S) ratios higher than 1.0, and amino acid residuces subject to diversifying selection are nonrandomly clustered on the exterior surface of the peptide. In addition, McDonald and Kreitman tests suggest that there has been historical but not current directional selection at fimA between E. coli and Salmonella. Finally, some regions of the fimA peptide appear to be under strong structural constraint within E. coli, particularly the interior regions of the molecule that is involved in subunit to subunit interaction. Recombination also plays a major role contributing to E. coli fimA allelic variation and estimates of recombination (2N(e)c) and mutation (2N(e)mu) are about the same. Recombination may act to separate the diverse evolutionary forces in different regions of the fimA peptide.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Peek AS,Souza V,Eguiarte LE,Gaut BSdoi
10.1007/s002390010148keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
193-204issue
2eissn
0022-2844issn
1432-1432pii
10.1007/s002390010148journal_volume
52pub_type
杂志文章abstract::Annotated, complete DNA sequences are available for 213 mitochondrial genomes from 132 species. These provide an extensive sample of evolutionary adjustment of codon usage and meaning spanning the history of this organelle. Because most known coding changes are mitochondrial, such data bear on the general mechanism of...
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journal_title:Journal of molecular evolution
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更新日期:1984-01-01 00:00:00
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更新日期:1984-01-01 00:00:00
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更新日期:1997-06-01 00:00:00
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journal_title:Journal of molecular evolution
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更新日期:1999-05-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006402
更新日期:1998-10-01 00:00:00
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journal_title:Journal of molecular evolution
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更新日期:2007-06-01 00:00:00
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abstract::DNA sequences representing approximately 40% of the large-subunit rRNA gene from the lower dipteran Chironomus thummi were analyzed. Once aligned with their Drosophila counterparts, sequence and base content comparisons were carried out. Sequence identity was found to be high overall, except for six regions that displ...
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更新日期:1995-08-01 00:00:00
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