Beyond the Frozen Accident: Glycine Assignment in the Genetic Code.

Abstract:

:tRNA with a terminal UCCA-3' forms a structure in which the 3'-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3' region, which places the glycine residue in close proximity to the 3'-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA. Thus, the UCCA-3'-containing tRNA (as seen in eubacterial tRNA(Gly)s) would possess an intrinsic property of glycylation by glycyl-AMP. This model provides a new perspective on the origins of the glycine assignment in the genetic code, beyond the "frozen accident" hypothesis.

journal_name

J Mol Evol

authors

Tamura K

doi

10.1007/s00239-015-9694-8

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

69-71

issue

3-4

eissn

0022-2844

issn

1432-1432

pii

10.1007/s00239-015-9694-8

journal_volume

81

pub_type

信件
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