当前位置： SCI文献检索 > JOURNAL OF MOLECULAR EVOLUTION期刊下所有文献 > The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.

The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.

Abstract：

:Four genes in the P450 IID gene subfamily were isolated from Sprague-Dawley rat lambda EMBL 3 and Charon 4A genomic libraries and completely sequenced. Their transcription start sites were determined by primer extension analysis. The four genes designated IID2, IID3, IID4, and IID5 span 4036, 4371, 4678, and 4567 bp, respectively, and are closely linked head to tail on a 60-kb segment of DNA. All IID genes contained nine exons, and interestingly, the IID2, IID3, and IID4 genes possessed an atypical GC5' splice junction in intron 2. All four genes are transcribed, however, IID4 mRNA is produced at a level of less than one-tenth of those of IID2, IID3, and IID5. The exonic regions of these genes displayed from 79 to 84% sequence similarties. Several regions of extremely high nucleotide similarity were found within the introns, exons, and in the flanking regions of the four genes. These localized areas of high nucleotide similarities are the result of former gene conversion events. Of interest was the finding that the most highly similar region of all IID genes that was maintained by gene conversion covers portions of the eighth and ninth exons and the eighth intron. The ninth exon codes for a region of the P450 protein that is well conserved among all P450 gene families and in all species and that is associated with the noncovalently bound heme iron at the enzyme's active site. These data indicate that gene conversions have maintained sequence homogeneity within a critical region of the four P450 IID proteins.

journal_name

J Mol Evol

journal_title

Journal of molecular evolution

authors

Matsunaga E,Umeno M,Gonzalez FJ

doi

10.1007/BF02099942

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

155-69

issue

2

eissn

0022-2844

issn

1432-1432

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR EVOLUTION文献大全
  • Organization and nucleotide sequence of a transcriptional unit of Methanococcus vannielii comprising genes for protein synthesis elongation factors and ribosomal proteins.

    abstract：:By a chromosome walking strategy the DNA region from Methanococcus vannielii flanking the genes for protein synthesis elongation factor (EF) 1 alpha and EF-2 was cloned and sequenced. A gene organization of 5' - beta' - open reading frame (ORF) 1 - ORF2 - S12 - S7 - EF-2 - EF-1 alpha - S10 - ORF3 - ORF4 - 3' was found...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF02106178

    authors： Lechner K,Heller G,Böck A

    更新日期：1989-07-01 00:00:00

  • Two paralogous genes encoding small subunits of ADP-glucose pyrophosphorylase in maize, Bt2 and L2, replace the single alternatively spliced gene found in other cereal species.

    abstract：:Two types of gene encoding small subunits (SSU) of ADP-glucose pyrophosphorylase, a starch-biosynthetic enzyme, have been found in cereals and other grasses. One of these genes encodes two SSU proteins. These are targeted to different subcellular compartments and expressed in different organs of the plant: the endospe...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-007-9013-0

    authors： Rösti S,Denyer K

    更新日期：2007-09-01 00:00:00

  • Recent evolutionary history of human immunodeficiency virus type 1 subtype B: reconstruction of epidemic onset based on sequence distances to the common ancestor.

    abstract：:We obtained and studied HIV-1 sequences with a known sampling year from three outbreaks of the HIV-1 epidemic: 141 env V3 (270 nt) sampled between 1984 and 1992 and 117 pol prot/RT (804 nt) sequences sampled between 1986 and 1999 from Dutch homosexual men and injecting drug users (IDUs), as well as 77 env V3 sequences...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-001-0070-5

    authors： Lukashov VV,Goudsmit J

    更新日期：2002-05-01 00:00:00

  • Evolution of HSP70 gene and its implications regarding relationships between archaebacteria, eubacteria, and eukaryotes.

    abstract：:The 70-kDa heat-shock protein (HSP70) constitutes the most conserved protein present in all organisms that is known to date. Based on global alignment of HSP70 sequences from organisms representing all three domains, numerous sequence signatures that are specific for prokaryotic and eukaryotic homologs have been ident...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF00182743

    authors： Gupta RS,Golding GB

    更新日期：1993-12-01 00:00:00

  • Molecular phylogeny of Allomyces macrogynus: congruency between nuclear ribosomal RNA- and mitochondrial protein-based trees.

    abstract：:We have sequenced the nuclear and mitochondrial small subunit rRNA genes (rns) and the mitochondrial genes coding for subunits 1 and 3 of the cytochrome oxidase (cox1 and cox3, respectively) of the chytridiomycete Allomyces macrogynus. Phylogenetic trees inferred from the derived COX1 and COX3 proteins and the nuclear...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF00175824

    authors： Paquin B,Forget L,Roewer I,Lang BF

    更新日期：1995-11-01 00:00:00

  • Abiogenic synthesis of oligonucleotides on kaolinite under the action of ultraviolet radiation.

    abstract：:The present work deals with the processes involved in the abiogenic polycondensation of nucleotides adsorbed on the clay mineral kaolinite under the action of ultraviolet (UV) radiation. The dependence of the yield of synthesis products on irradiation dose was studied. The maximum yield corresponds to a 6-h exposure. ...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF02100636

    authors： Strigunkova TF,Lavrentiev GA,Otroshchenko VA

    更新日期：1986-01-01 00:00:00

  • Substitutional bias confounds inference of cyanelle origins from sequence data.

    abstract：:Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (subst...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF00182392

    authors： Lockhart PJ,Howe CJ,Bryant DA,Beanland TJ,Larkum AW

    更新日期：1992-02-01 00:00:00

  • Organization and evolution of the mitochondrial DNA control region in the avian genus Alectoris.

    abstract：:The entire mitochondrial DNA control region (mtDNA D-loop) was sequenced in the seven extant species of Alectoris partridges. The D-loop length is very conserved (1155 +/- 2 nucleotides), and substitution rates are lower than for the mitochondrial cytochrome b gene of the same species, on average. Comparative analyses...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/pl00006402

    authors： Randi E,Lucchini V

    更新日期：1998-10-01 00:00:00

  • Novel hydrophobins from Trichoderma define a new hydrophobin subclass: protein properties, evolution, regulation and processing.

    abstract：:Hydrophobins are small proteins, characterised by the presence of eight positionally conserved cysteine residues, and are present in all filamentous asco- and basidiomycetes. They are found on the outer surfaces of cell walls of hyphae and conidia, where they mediate interactions between the fungus and the environment...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-011-9438-3

    authors： Seidl-Seiboth V,Gruber S,Sezerman U,Schwecke T,Albayrak A,Neuhof T,von Döhren H,Baker SE,Kubicek CP

    更新日期：2011-04-01 00:00:00

  • The mitochondrial genome of Xiphinema americanum sensu stricto (Nematoda: Enoplea): considerable economization in the length and structural features of encoded genes.

    abstract：:The complete sequence of the mitochondrial genome of the plant parasitic nematode Xiphinema americanum sensu stricto has been determined. At 12626bp it is the smallest metazoan mitochondrial genome reported to date. Genes are transcribed from both strands. Genes coding for 12 proteins, 2 rRNAs and 17 putative tRNAs (w...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-005-0102-7

    authors： He Y,Jones J,Armstrong M,Lamberti F,Moens M

    更新日期：2005-12-01 00:00:00

  • Identification of three distinct phylogenetic groups of CAX cation/proton antiporters.

    abstract：:Ca(2+)/cation antiporter (CaCA) proteins are integral membrane proteins that transport Ca(2+) or other cations using the H(+) or Na(+) gradient generated by primary transporters. The CAX (for CAtion eXchanger) family is one of the five families that make up the CaCA superfamily. CAX genes have been found in bacteria, ...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-006-0048-4

    authors： Shigaki T,Rees I,Nakhleh L,Hirschi KD

    更新日期：2006-12-01 00:00:00

  • The 5S rDNA high dynamism in Diplodus sargus is a transposon-mediated mechanism. Comparison with other multigene families and Sparidae species.

    abstract：:There has been considerable discussion in recent years on the evolution of the tandemly repeated multigene families, since some organisms show a concerted model whereas others show a birth-and-death model. This controversial subject extends to several species of fish. In this study, three species of the Sparidae famil...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-013-9541-8

    authors： Merlo MA,Cross I,Manchado M,Cárdenas S,Rebordinos L

    更新日期：2013-03-01 00:00:00

  • Phylogeny and self-splicing ability of the plastid tRNA-Leu group I Intron.

    abstract：:Group I introns are mobile RNA enzymes (ribozymes) that encode conserved primary and secondary structures required for autocatalysis. The group I intron that interrupts the tRNA-Leu gene in cyanobacteria and plastids is remarkable because it is the oldest known intervening sequence and may have been present in the com...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-003-2533-3

    authors： Simon D,Fewer D,Friedl T,Bhattacharya D

    更新日期：2003-12-01 00:00:00

  • Nucleotide composition as a driving force in the evolution of retroviruses.

    abstract：:All complete retrovirus sequences in the GenEMBL database were examined with the goal of assessing possible relationships between the nucleotide composition of retroviral genomes, the amino acid composition of retroviral proteins, and evolutionary strategies used by retroviruses. The results demonstrated that the geno...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF00178851

    authors： Bronson EC,Anderson JN

    更新日期：1994-05-01 00:00:00

  • Positive Darwinian selection drives the evolution of the morphology-related gene, EPCAM, in particularly species-rich lineages of African cichlid fishes.

    abstract：:The study of genetic evolution within the context of adaptive radiations offers insights to genes and selection pressures that result in rapid morphological change. Cichlid fishes are very species-rich and variable in coloration, behavior, and morphology, and so provide a classical model system for studying the geneti...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-011-9452-5

    authors： Fan S,Elmer KR,Meyer A

    更新日期：2011-08-01 00:00:00

  • Distinct evolutionary patterns between two duplicated color vision genes within cyprinid fishes.

    abstract：:We investigated the molecular evolution of duplicated color vision genes (LWS-1 and SWS2) within cyprinid fish, focusing on the most cavefish-rich genus--Sinocyclocheilus. Maximum likelihood-based codon substitution approaches were used to analyze the evolution of vision genes. We found that the duplicated color visio...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-009-9283-9

    authors： Li Z,Gan X,He S

    更新日期：2009-10-01 00:00:00

  • The influence of historical geneflow, bathymetry and distribution patterns on the population genetics of morphologically diverse Galápagos' Opuntia echios.

    abstract：:Throughout history, remote archipelagos have repeatedly been designated natural laboratories to study evolutionary processes. The extensive, geographically structured, morphological variation within Galápagos' Opuntia cacti has been presumed to be another example of how such processes shape diversity. However, recent ...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-011-9434-7

    authors： Helsen P,Verdyck P,Van Dongen S

    更新日期：2011-03-01 00:00:00

  • Why are young and old repetitive elements distributed differently in the human genome?

    abstract：:Alu elements are not distributed homogeneously throughout the human genome: old elements are preferentially found in the GC-rich parts of the genome, while young Alus are more often found in the GC-poor parts of the genome. The process giving rise to this differential distribution remains poorly understood. Here we in...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-004-0020-0

    authors： Belle EM,Webster MT,Eyre-Walker A

    更新日期：2005-03-01 00:00:00

  • Radionuclide-induced evolution of DNA and the origin of life.

    abstract：:Artesian groundwaters of high radionuclide concentration are ubiquitous and may have provided the large, sustained energy sources that were required to drive the multistage process of DNA and primordial cell evolution. The rapid, early development of the genetic code as well as its degeneracy can be attributed to exce...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF00161172

    authors： Martell EA

    更新日期：1992-10-01 00:00:00

  • Positive Darwinian selection at single amino acid sites conferring plant virus resistance.

    abstract：:Explicit evaluation of the accuracy and power of maximum likelihood and Bayesian methods for detecting site-specific positive Darwinian selection presents a challenge because selective consequences of single amino acid changes are generally unknown. We exploited extensive molecular and functional characterization of a...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-008-9172-7

    authors： Cavatorta JR,Savage AE,Yeam I,Gray SM,Jahn MM

    更新日期：2008-11-01 00:00:00

  • Kinetics of synonymous codon change for an amino acid of arbitrary degeneracy.

    abstract：:The kinetics of synonymous codon change and species divergence is described in a matrix formalism that is equally applicable to all levels of codon degeneracy and all levels of codon or nucleotide bias. Based on the formalism it is possible to calculate the sum of all synonymous substitution rate constants from the ob...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF00186546

    authors： Berg OG

    更新日期：1995-09-01 00:00:00

  • Beyond the Frozen Accident: Glycine Assignment in the Genetic Code.

    abstract：:tRNA with a terminal UCCA-3' forms a structure in which the 3'-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3' region, which places the glycine residue in close proximity to the 3'-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA...

    journal_title：Journal of molecular evolution

    pub_type： 信件

    doi：10.1007/s00239-015-9694-8

    authors： Tamura K

    更新日期：2015-10-01 00:00:00

  • ApA dinucleotide periodicity in prokaryote, eukaryote, and organelle genomes.

    abstract：:Computer analyses of various genome sequences revealed the existence of certain periodical patterns of adenine-adenine dinucleotides (ApA). For each genome sequence of 13 eubacteria, 3 archaebacteria, 10 eukaryotes, 60 mitochondria, and 9 chloroplasts, we counted frequencies of ApA dinucleotides at each downstream pos...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/pl00006541

    authors： Tomita M,Wada M,Kawashima Y

    更新日期：1999-08-01 00:00:00

  • Thermodynamics of peptide bond formation at clay mineral surfaces.

    abstract：:The possibility of surface catalysed condensation of unsubstituted amino acids on kaolinite in aqueous systems at elevated temperatures was investigated; no evidence of clay catalysed polycondensation has been found. The thermodynamic feasibility of the hypothetical lysine/dilysine condensation reaction in the tempera...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF01733261

    authors： Flegmann AW,Scholefield D

    更新日期：1978-12-29 00:00:00

  • Heat shocks do not mobilize mobile elements in genomes of Drosophila melanogaster inbred lines.

    abstract：:Males of three inbred lines of Drosophila melanogaster were heat-shocked 90 min at 37 degrees C. The progenies from treated and untreated males mated with untreated females of the same line were checked for their chromosomal insertion patterns of various mobile elements by either in situ hybridization or Southern blot...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF02603073

    authors： Arnault C,Biémont C

    更新日期：1989-05-01 00:00:00

  • Selection conflicts, gene expression, and codon usage trends in yeast.

    abstract：:Synonymous codon usage in yeast appears to be influenced by natural selection on gene expression, as well as regional variation in compositional bias. Because of the large number of potential targets of selection (i.e., most of the codons in the genome) and presumed small selection coefficients, codon usage is an exce...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-003-2459-9

    authors： Kliman RM,Irving N,Santiago M

    更新日期：2003-07-01 00:00:00

  • Classification of scorpion toxins according to amino acid composition and sequence.

    abstract：:Scorpion venom toxins were systematically classified according to amino acid composition, insertion/deletion events and sequence. The significance of each comparison method and its outcome is discussed in relation to known immunological and structural properties. A general classification of the toxins is proposed that...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/BF02257372

    authors： Dufton MJ,Rochat H

    更新日期：1984-01-01 00:00:00

  • The effect of local nucleotides on synonymous codon usage in the honeybee (Apis mellifera L.) genome.

    abstract：:Using all currently predicted coding regions in the honeybee genome, a novel form of synonymous codon bias is presented that affects the usage of particular codons dependent on the surrounding nucleotides in the coding region. Nucleotides at the third codon site are correlated, dependent on their weak (adenine [A] or ...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-006-0198-4

    authors： Cutler RW,Chantawannakul P

    更新日期：2007-06-01 00:00:00

  • Coordinated amino acid changes in the evolution of mammalian defensins.

    abstract：:The mammalian defensin molecule is a short, highly cationic peptide cytotoxic to both microbial and mammalian cells which is cleaved from a precursor including a signal peptide and a highly anionic propiece. A phylogenetic analysis of 28 complete sequences from five mammalian species (mouse, rat, guinea pig, rabbit, a...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/pl00006191

    authors： Hughes AL,Yeager M

    更新日期：1997-06-01 00:00:00

  • Slow mitochondrial COI sequence evolution at the base of the metazoan tree and its implications for DNA barcoding.

    abstract：:The evolution rates of mtDNA in early metazoans hold important implications for DNA barcoding. Here, we present a comprehensive analysis of intra- and interspecific COI variabilities in Porifera and Cnidaria (separately as Anthozoa, Hydrozoa, and Scyphozoa) using a data set of 619 sequences from 224 species. We found ...

    journal_title：Journal of molecular evolution

    pub_type： 杂志文章

    doi：10.1007/s00239-008-9069-5

    authors： Huang D,Meier R,Todd PA,Chou LM

    更新日期：2008-02-01 00:00:00