Abstract：
:Alu elements are not distributed homogeneously throughout the human genome: old elements are preferentially found in the GC-rich parts of the genome, while young Alus are more often found in the GC-poor parts of the genome. The process giving rise to this differential distribution remains poorly understood. Here we investigate whether this pattern could be due to a preferential degradation of Alu elements integrated in GC-poor regions by small indel mutations. We aligned 5.1 Mb of human and chimpanzee sequences and examined whether the rate of insertion and deletion inside Alu elements differed according to the base composition surrounding them. We found that Alu elements are not preferentially degraded in GC-poor regions by indel events. We also looked at whether very young L1 elements show the same change in distribution compared to older ones. This analysis indicated that L1 elements also show a shift in their distribution, although we could not assess it as precisely as for Alu elements. We propose that the differential distribution of Alu elements is likely to be due to a change in their pattern of insertion or their probability of fixation through evolutionary time.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Belle EM,Webster MT,Eyre-Walker Adoi
10.1007/s00239-004-0020-0keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
290-6issue
3eissn
0022-2844issn
1432-1432journal_volume
60pub_type
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