Radionuclide-induced evolution of DNA and the origin of life.

Abstract:

:Artesian groundwaters of high radionuclide concentration are ubiquitous and may have provided the large, sustained energy sources that were required to drive the multistage process of DNA and primordial cell evolution. The rapid, early development of the genetic code as well as its degeneracy can be attributed to exceptionally high radiation-induced mutation rates in this unique environment. The ability of double-strand DNA to direct enzymatic repair of radiation damage to single strands contributed importantly to its selective evolution. It is postulated that the polymerization of nucleotides took place at elevated temperatures within alpha-particle tracks of high ion and free-radical density, followed by rapid quenching to ambient conditions. It also is evident that radiation resistance and ploidy were important selection factors in cellular evolution.

journal_name

J Mol Evol

authors

Martell EA

doi

10.1007/BF00161172

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

346-55

issue

4

eissn

0022-2844

issn

1432-1432

journal_volume

35

pub_type

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