Abstract:
:Several distinct families of endogenous retroviruses exist in the genomes of primates. Most of them are remnants of ancient germ-line infections. The human endogenous retrovirus family HERV-K represents the unique known case of endogenous retrovirus that amplified in the human genome after the divergence of human and chimpanzee lineages. There are two types of HERV-K proviral genomes differing by the presence or absence of 292 bp in the pol-env boundary. Human-specific insertions exist for both types. The analyses shown in the present work reveal that several lineages of type 1 and type 2 HERV-K proviruses remained transpositionally active after the human/chimpanzee split. The data also reflect the important role of mosaic evolution (either by recombination or gene conversion) during the evolutionary history of HERV-K.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Costas Jdoi
10.1007/s002390010213keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
237-43issue
3eissn
0022-2844issn
1432-1432journal_volume
53pub_type
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