Abstract：
:A major goal of evolutionary biology is to understand how beneficial mutations translate into increased fitness. Here, we study beneficial mutations that arise in experimental populations of yeast evolved in glucose-rich media. We find that fitness increases are caused by enhanced maximum growth rate (R) that come at the cost of reduced yield (K). We show that for some of these mutants, high R coincides with higher rates of ethanol secretion, suggesting that higher growth rates are due to an increased preference to utilize glucose through the fermentation pathway, instead of respiration. We examine the performance of mutants across gradients of glucose and nitrogen concentrations and show that the preference for fermentation over respiration is influenced by the availability of glucose and nitrogen. Overall, our data show that selection for high growth rates can lead to an enhanced Crabtree phenotype by the way of beneficial mutations that permit aerobic fermentation at a greater range of glucose concentrations.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Sezmis AL,Malerba ME,Marshall DJ,McDonald MJdoi
10.1007/s00239-018-9829-9subject
Has Abstractpub_date
2018-02-01 00:00:00pages
111-117issue
2eissn
0022-2844issn
1432-1432pii
10.1007/s00239-018-9829-9journal_volume
86pub_type
杂志文章abstract：:This study examines the diverse maximum wavelength absorption (lambdamax) found in crayfishes (Decapoda: Cambaridae and Parastacidae) and the associated genetic variation in their opsin locus. We measured the wavelength absorption in the photoreceptors of six species that inhabit environments of different light intens...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006257
更新日期：1997-11-01 00:00:00
abstract：:The NF-κB family of transcription factors is activated in response to many environmental and biological stresses, and plays a key role in innate immunity across a broad evolutionary expanse of animals. A simple NF-κB pathway is present in the sea anemone Nematostella vectensis, an important model organism in the phylu...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-011-9479-7
更新日期：2011-12-01 00:00:00
abstract：:The possibility of surface catalysed condensation of unsubstituted amino acids on kaolinite in aqueous systems at elevated temperatures was investigated; no evidence of clay catalysed polycondensation has been found. The thermodynamic feasibility of the hypothetical lysine/dilysine condensation reaction in the tempera...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01733261
更新日期：1978-12-29 00:00:00
abstract：:There have been two distinct phases of evolution of the genetic code: an ancient phase--prior to the divergence of the three domains of life, during which the standard genetic code was established--and a modern phase, in which many alternative codes have arisen in specific groups of genomes that differ only slightly f...
journal_title：Journal of molecular evolution
pub_type： 杂志文章,评审
doi：10.1007/s00239-015-9686-8
更新日期：2015-06-01 00:00:00
abstract：:The semen of many primate species coagulates into a mating plug believed to prevent the sperm of subsequent mating events from accessing the ova. The texture of the coagulum varies among species: from a semisoft mass in humans to a firm plug in chimpanzees. In humans, a component of the coagulum, semenogelin I, also i...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-002-2463-0
更新日期：2003-08-01 00:00:00
abstract：:The availability of fast and accurate sequencing procedures along with the use of PCR has led to a proliferation of studies of variability at the molecular level in populations. Nevertheless, it is often impractical to examine long genomic stretches and a large number of individuals at the same time. In order to optim...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00173194
更新日期：1995-12-01 00:00:00
abstract：:The gas chromatograph mass spectrometer instrument of the Viking mission has demonstrated the absence of organic compounds in the immediate surface layer of the two landing sites. The demonstration of the successful operation of the instrument (comparison of ground-based test data with those obtained during interplane...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01732368
更新日期：1979-12-01 00:00:00
abstract：:This study dealt with the ability of non-denaturing gel electrophoresis to separate iso-1-cytochrome c with single amino acid replacements isolated from revertants of various cyc1 nonsense mutants of the yeast Saccharomyces cerevisiae. A total of 28 different iso-1-cytochromes c with single amino acid substitutions of...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02102869
更新日期：1991-10-01 00:00:00
abstract：:RNA editing affecting chloroplast and mitochondrial genomes has been identified in all major clades of land plants. The frequency of edited sites varies greatly between lineages but hornworts represent an extreme in propensity for editing in both their chloroplast and mitochondrial genomes. cDNA sequences from seven t...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-004-0146-0
更新日期：2005-11-01 00:00:00
abstract：:Nuclear DNA contents were estimated by microdensitometry in five species of Akodon rodents: Arodon molinae, A. dolores, A. mollis, A. azarae, Bolomys obscurus) and in three chromosomal varieties of A. molinae (2n = 42; 2n = 43, 2n = 22). The data obtained showed that the species with the highest DNA content was B. obs...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02101640
更新日期：1983-01-01 00:00:00
abstract：:Ca(2+)/cation antiporter (CaCA) proteins are integral membrane proteins that transport Ca(2+) or other cations using the H(+) or Na(+) gradient generated by primary transporters. The CAX (for CAtion eXchanger) family is one of the five families that make up the CaCA superfamily. CAX genes have been found in bacteria, ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-006-0048-4
更新日期：2006-12-01 00:00:00
abstract：:The bacterial endosymbionts (Buchnera) from the aphids Rhopalosiphum padi, R. maidis, Schizaphis graminum, and Acyrthosiphon pisum contain the genes for anthranilate synthase (trpEG) on plasmids made up of one or more 3.6-kb units. Anthranilate synthase is the first as well as the rate-limiting enzyme in the tryptopha...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02498635
更新日期：1996-04-01 00:00:00
abstract：:The evolutionary relationships among arthropod hemocyanins and insect hexamerins were investigated. A multiple sequence alignment of 12 hemocyanin and 31 hexamerin subunits was constructed and used for studying sequence conservation and protein phylogeny. Although hexamerins and hemocyanins belong to a highly divergen...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006366
更新日期：1998-07-01 00:00:00
abstract：:Twenty-one different caprine and 13 ovine MHC-DRB exon 2 sequences were determined including part of the adjacent introns containing simple repetitive (gt)n(ga)m elements. The positions for highly polymorphic DRB amino acids vary slightly among ungulates and other mammals. From man and mouse to ungulates the basic (gt...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00175503
更新日期：1993-09-01 00:00:00
abstract：:The early evolution of life is a period with many important events with a lot of big and open questions. One of them is the evolution of metabolic pathways, which means the origin and assembly of enzymes that act together. The retrograde hypothesis was the first attempt to explain the origin and evolutionary history o...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-021-09994-0
更新日期：2021-01-28 00:00:00
abstract：:The dominant paradigm in origin of life research is that of an RNA world. However, despite experimental progress towards the spontaneous formation of RNA, the RNA world hypothesis still has its problems. Here, we introduce a novel computational model of chemical reaction networks based on RNA secondary structure and a...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-017-9787-7
更新日期：2017-04-01 00:00:00
abstract：:Restriction modification (RM) systems serve to protect bacteria against bacteriophages. They comprise a restriction endonuclease activity that specifically cleaves DNA and a corresponding methyltransferase activity that specifically methylates the DNA, thereby protecting it from cleavage. Such systems are very common ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02198833
更新日期：1996-02-01 00:00:00
abstract：:LINE-1 (L1) elements constitute the major family of retrotransposons in mammalian genomes. Here we report the first investigation of L1 evolution in New World monkeys (NWM). Two regions of the second open-reading frame were analyzed by two methods in three NWM species, the squirrel monkey (Saimiri sciureus), the tamar...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-003-2539-x
更新日期：2004-01-01 00:00:00
abstract：:It is generally considered that if an RNA World ever existed that it would be driven by an RNA capable of RNA replication. Whether such a catalytic RNA could emerge in an RNA World or not, there would need to be prior routes to increasing complexity in order to produce it. It is hypothesized here that increasing seque...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-018-9846-8
更新日期：2018-06-01 00:00:00
abstract：:Bacterial family C DNA polymerases (DNA pol IIIs), the major chromosomal replicative enzymes, have been provisionally classified based on primary sequences and domain structures into three classes: class I (Escherichia coli DNA pol C-type), class II (Bacillus subtilis DNA pol C-type), and class III (cyanobacterial DNA...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006520
更新日期：1999-06-01 00:00:00
abstract：:The mitochondrial cytochrome b (cyt-b) gene is widely used in systematic studies to resolve divergences at many taxonomic levels. The present study focuses mainly on the utility of cyt-b as a molecular marker for inferring phylogenetic relationship at various levels within the fish family Cichlidae. A total of 78 taxa...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s002390010197
更新日期：2001-08-01 00:00:00
abstract：:In this work detailed statistics on ancestral gene duplication and gene conservation in completely sequenced cellular genomes are presented. Analysis of open reading frame (ORF) products having simultaneous matches in several distinct organisms showed a significant correlation between duplication and conservation. Sys...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006580
更新日期：1999-11-01 00:00:00
abstract：:Eight human short tandem repeat polymorphisms (STRs) also known as microsatellites-DYS19, DYS388, DYS390, DYS391, DYS392, DYS393, DYS389I, and DYS389II, mapping in the Y chromosome-were analyzed in two Iberian samples (Basques and Catalans). Allele frequency distributions showed significant differences only for DYS392...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006229
更新日期：1997-09-01 00:00:00
abstract：:Using all currently predicted coding regions in the honeybee genome, a novel form of synonymous codon bias is presented that affects the usage of particular codons dependent on the surrounding nucleotides in the coding region. Nucleotides at the third codon site are correlated, dependent on their weak (adenine [A] or ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-006-0198-4
更新日期：2007-06-01 00:00:00
abstract：:Microsatellite DNA sequences have become the dominant source of nuclear genetic markers for most applications. It is important to investigate the basis of variation between alleles and to know if current assumptions about the mechanisms of microsatellite mutation (that is to say, variations involving simple changes in...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006151
更新日期：1997-03-01 00:00:00
abstract：:The complete mitochondrial DNA (mtDNA) sequence of the brine shrimp Artemia franciscana has been determined. It extends the present knowledge of mitochondrial genomes to the crustacean class and supplies molecular markers for future comparative studies in this large branch of the arthropod phylum. Artemia mtDNA is 15,...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00160272
更新日期：1994-10-01 00:00:00
abstract：:The trnT-trnF region is located in the large single-copy region of the chloroplast genome. It consists of the trnL intron, a group I intron, and the trnT-trnL and trnL-trnF intergenic spacers. We analyzed the evolution of the region in the three genera of the gymnosperm lineage Gnetales (Gnetum, Welwitschia, and Ephed...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-004-0240-3
更新日期：2005-10-01 00:00:00
abstract：:The internal transcribed spacer region (ITS) of the nuclear rDNA cistron represents the barcoding locus for Fungi. Intragenomic variation of this multicopy gene can interfere with accurate phylogenetic reconstruction of biological entities. We investigated the amount and nature of this variation for the lichenized fun...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-013-9603-y
更新日期：2014-02-01 00:00:00
abstract：:The phylogenetic relationships among the major groups of amniote vertebrates remain a matter of controversy. Various alternatives for the position of the turtles have been proposed, branching off either before or after the mammals. To discover the phylogenetic position of turtles in relation to mammals and birds, we h...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02352288
更新日期：1996-05-01 00:00:00
abstract：:We have continued our program aimed at understanding the origin and evolution of the genetic code and the process of protein synthesis by comparing the rates of esterification of 5'-AMP by a series of hydrophobic N-acetylamino acids. The reaction clearly shows differences in reaction rate (AcPhe greater than AcLeu gre...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02101000
更新日期：1986-01-01 00:00:00
