Abstract:
:The availability of fast and accurate sequencing procedures along with the use of PCR has led to a proliferation of studies of variability at the molecular level in populations. Nevertheless, it is often impractical to examine long genomic stretches and a large number of individuals at the same time. In order to optimize this kind of study, we suggest a heuristic procedure for detection of the shortest region whose informational content can be considered sufficient for significant phylogenetic reconstruction. The method is based on the comparison of the pairwise genetic distances obtained from a set of sequences of reference to those obtained for different windows of variable size and position by means of a simple index. We also present an approach for testing whether the informative content in the stretches selected in this way is significantly different from the corresponding content shown by the larger genomic regions used as reference. Application of this test to the analysis of the VP1 protein gene of foot-and-mouth-disease type C virus allowed us to define optimal stretches whose informative content is not significantly different from that displayed by the complete VP1 sequence. We showed that the predictions made for type C sequences are valid for type O sequences, indicating that the results of the procedure are consistent.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Martin MJ,González-Candelas F,Sobrino F,Dopazo Jdoi
10.1007/BF00173194subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1128-38issue
6eissn
0022-2844issn
1432-1432journal_volume
41pub_type
杂志文章abstract::Hemoglobin Vancouver is a new abnormal hemoglobin with an amino acid substitution of the normal aspartyl residue 73 of the beta chain by a tyrosyl residue. It was discovered in a man of Chinese descent in association with beta thalassemia. It was subsequently detected in a sister in association with normal Hb A. The o...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01796121
更新日期:1976-12-31 00:00:00
abstract::Two competing effects at two vastly different scales may explain collagen's current translation length. The necessity to have long molecules for maintaining mechanical integrity at the organism and supraorganism scales may be limited by the need to have small molecules capable of robust self-assembly at the nanoscale....
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-008-9111-7
更新日期:2008-06-01 00:00:00
abstract::Segmental pattern in Drosophila melanogaster is set up via a set of cell-cell interactions mediated by the products of the segment polarity genes. Among these is the armadillo gene, whose product seems to be required for the reception of an intercellular signal encoded by the wingless gene. As part of our effort to re...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00160477
更新日期:1993-03-01 00:00:00
abstract::The efficiency of obtaining the correct tree by the maximum likelihood method (Felsenstein 1981) for inferring trees from DNA sequence data was compared with trees obtained by distance methods. It was shown that the maximum likelihood method is superior to distance methods in the efficiency particularly when the evolu...
journal_title:Journal of molecular evolution
pub_type: 评论,杂志文章
doi:10.1007/BF02101285
更新日期:1991-05-01 00:00:00
abstract::Phospholipid vesicles (liposomes) were subjected to dehydration-hydration cycles in the presence of 6-carboxyfluorescein or salmon sperm DNA. We found that the vesicles fused into multilamellar structures during dehydration with solutes trapped between the lamellae. Upon rehydration the lamellae swelled and formed lar...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01733047
更新日期:1982-01-01 00:00:00
abstract::The recent availability of genome sequences of four different Fusarium species offers the opportunity to perform extensive comparative analyses, in particular of repeated sequences. In a recent work, the overall content of such sequences in the genomes of three phylogenetically related Fusarium species, F. graminearum...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-011-9472-1
更新日期:2011-10-01 00:00:00
abstract::As the origin(s) of life on Earth remains an open question, detailed characteristics about the "last universal ancestor" (LUA) continue to be obscured. Here we provide arguments that strengthen the bacterial-like nature of the LUA. Our view attempts to recreate the evolution of archaeal lipids, the major components of...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-006-0141-8
更新日期:2007-03-01 00:00:00
abstract::The human S100 gene family encodes the EF-hand superfamily of calcium-binding proteins, with at least 14 family members clustered relatively closely together on chromosome 1q21. We have analyzed the most recently available genomic sequence of the human S100 gene cluster for evidence of tandem gene duplications during ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-002-2410-5
更新日期:2003-04-01 00:00:00
abstract::Cot and chemical analysis show that the haploid genome size of Thermobia domestica is 3-4x10(9) nucleotide pairs. Of this DNA 33% is single copy sequences and 67% is repetitive sequences. The repetitive sequences are predominantly 300 nucleotides in length and are interspersed among the single copy sequences in a shor...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01733135
更新日期:1980-08-01 00:00:00
abstract::Ca(2+)/cation antiporter (CaCA) proteins are integral membrane proteins that transport Ca(2+) or other cations using the H(+) or Na(+) gradient generated by primary transporters. The CAX (for CAtion eXchanger) family is one of the five families that make up the CaCA superfamily. CAX genes have been found in bacteria, ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-006-0048-4
更新日期:2006-12-01 00:00:00
abstract::The glycosylation characteristics of the digestive enzyme ribonuclease are summarized. The evolutionary role of this posttranslational modification is discussed and evidence is presented that selection has much influence on the presence or absence of carbohydrate in glycoproteins and on the positions of the carbohydra...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099959
更新日期:1986-01-01 00:00:00
abstract::In this study, the molecular population genetics of the orangutan's alpha-2 globin (HBA2) gene were investigated in order to test for the action of natural selection. Haplotypes from 28 orangutan chromosomes were collected from a 1.46-kilobase region of the alpha-2 globin locus. While many aspects of the data were con...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-0201-x
更新日期:2005-03-01 00:00:00
abstract::We propose a genealogy-sampling algorithm, Sequential Markov Ancestral Recombination Tree (SMARTree), that provides an approach to estimation from SNP haplotype data of the patterns of coancestry across a genome segment among a set of homologous chromosomes. To enable analysis across longer segments of genome, the seq...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-014-9620-5
更新日期:2014-05-01 00:00:00
abstract::Complete chloroplast 23S rRNA and psbA genes from five peridinin-containing dinoflagellates (Heterocapsa pygmaea, Heterocapsa niei, Heterocapsa rotun-data, Amphidinium carterae, and Protoceratium reticulatum) were amplified by PCR and sequenced; partial sequences were obtained from Thoracosphaera heimii and Scrippsiel...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s002390010064
更新日期:2000-07-01 00:00:00
abstract::The codons in four mammalian messenger RNAs (rabbit beta hemoglobin, rat pre-proinsulin, rat pre-growth hormone and human chorionic somatomammotropin) show a predominance of C and G in third nucleotide positions. The C:U ratio is about 2 to 1, and the G:A ratio is about 4 to 1. The possibility is discussed that this d...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01733888
更新日期:1978-06-20 00:00:00
abstract::Oxygen-free aqueous solutions of NH4CN (0.1 M, pH9) were exposed to gamma rays from a 60Co source, the mixture of nonvolatile products was fractionated, and the fractions were analyzed. The procedures were chosen to make effective investigations of radiolytic products, and to minimize the contributions of chemical cha...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01732951
更新日期:1980-07-01 00:00:00
abstract::Transfer RNA (tRNA) is the central intellectual property in the evolution of life on Earth. tRNA evolved from repeats and inverted repeats of known sequence. The anticodon and the T stem-loop-stems are homologs with significant conserved sequence identity. A number of models have been advanced to explain tRNA evolutio...
journal_title:Journal of molecular evolution
pub_type: 信件
doi:10.1007/s00239-020-09928-2
更新日期:2020-04-01 00:00:00
abstract::The previously given systems-theoretic model for the synthesis of optical antipodes (AD and AL) in strongly asymmetric yield, which shows mono-bistable behaviour depending on the degree of "openess" of the chemical reaction system is reconsidered for two equal compartments (subscripts 1 and 2 on A) with coupling by di...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01732292
更新日期:1975-10-29 00:00:00
abstract::Species identification is one of the most important issues in biological studies. Due to recent increases in the amount of genomic information available and the development of DNA sequencing technologies, the applicability of using DNA sequences to identify species (commonly referred to as "DNA barcoding") is being te...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-010-9380-9
更新日期:2010-10-01 00:00:00
abstract::The LMP7 and PSMB5 genes were created through an ancient gene duplication event of their ancestral locus. These proteins contain an active site of proteolysis, and LMP7 replaces PSMB5 as a component of the 20S proteasome after stimulation of cells by interferon-gamma. Replacement of PSMB5 by LMP7 changes the profile o...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-0120-x
更新日期:2005-02-01 00:00:00
abstract::The possibility of surface catalysed condensation of unsubstituted amino acids on kaolinite in aqueous systems at elevated temperatures was investigated; no evidence of clay catalysed polycondensation has been found. The thermodynamic feasibility of the hypothetical lysine/dilysine condensation reaction in the tempera...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01733261
更新日期:1978-12-29 00:00:00
abstract::Marine mussels of the genus Mytilus have two types of mitochondrial DNA with separate paternal and maternal inheritance. Females are homoplasmic for an F genome that is transmitted to all offspring, whereas males are heteroplasmic for this F genome and for a highly diverged (> 20%) M genome that is transmitted only to...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-003-0019-y
更新日期:2003-01-01 00:00:00
abstract::Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (subst...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00182392
更新日期:1992-02-01 00:00:00
abstract::51 polypeptides of known 3-dimensional structures have been submitted to a search for internal similarities. It is shown that the frequency of proteins displaying significant amounts of internal similarities is higher than predicted by chance. A non-negligible part of those similarities probably occurs in connection w...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101639
更新日期:1983-01-01 00:00:00
abstract::Using gene genealogies constructed from gene sequence data, we show that both the mucosal and cutaneous papillomaviruses (PV)-supergroups A and B-appear to have been transmitted through susceptible populations faster than exponentially. The data and methods involved (1) examining the PV database for phylogenetic signa...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006136
更新日期:1997-02-01 00:00:00
abstract::Multiple phospholipase A2 (PLA2) isoenzymes found in a single snake venom induce a variety of pharmacological effects. These multiple forms are formed by gene duplication and accelerated evolution of exons. We examined the amino acid sequences of 127 snake venom PLA2 enzymes and their homologues to study in which loca...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006450
更新日期:1999-02-01 00:00:00
abstract::The amino acid sequences of 22 alpha-amylases from family 13 of glycosyl hydrolases were analyzed with the aim of revealing the evolutionary relationships between the archaeal alpha-amylases and their eubacterial and eukaryotic counterparts. Two evolutionary distance trees were constructed: (i) the first one based on ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006486
更新日期:1999-04-01 00:00:00
abstract::Exon-shuffling is an important mechanism accounting for the origin of many new proteins in eukaryotes. However, its role in the creation of proteins in the ancestor of prokaryotes and eukaryotes is still debatable. Excess of symmetric exons is thought to represent evidence for exon-shuffling since the exchange of exon...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-0318-y
更新日期:2005-09-01 00:00:00
abstract::Barnacles (Cirripedia) are a subclass of Crustacea. Their peculiar segmentation pattern (few segments, absence of abdominal segments, and, in the parasitic rhizocephalan, loss of segmentation at the adult stage) prompted us to study the engrailed gene, which encodes a homeodomain transcription factor and is expressed ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006181
更新日期:1997-06-01 00:00:00
abstract::Copia is a retrotransposon that appears to be distributed widely among the Drosophilidae subfamily. Evolutionary analyses of regulatory regions have indicated that the Copia retrotransposon evolved through both positive and purifying selection, and that horizontal transfer (HT) could also explain its patchy distributi...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-011-9435-6
更新日期:2011-03-01 00:00:00