Abstract:
:The codons in four mammalian messenger RNAs (rabbit beta hemoglobin, rat pre-proinsulin, rat pre-growth hormone and human chorionic somatomammotropin) show a predominance of C and G in third nucleotide positions. The C:U ratio is about 2 to 1, and the G:A ratio is about 4 to 1. The possibility is discussed that this disproportionally resulted from DNA replicative errors that favor C.G pairs over A.T pairs, as found in the E. coli mut T strain. "Nearest neighbor" base pairs ("doublets") in the protein-coding regions of phiX174 and in four mammalian mRNAs have been compared. Mammalian mRNA has a low content of CpG in comparison with expectations from its C and G content.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Jukes THdoi
10.1007/BF01733888subject
Has Abstractpub_date
1978-06-20 00:00:00pages
121-7issue
2eissn
0022-2844issn
1432-1432journal_volume
11pub_type
杂志文章abstract::It has been suggested that inorganic membranes were forerunners of organic membranes at the origin of life. Such membranes, interposed between alkaline fluid in submarine vents and the more acidic Hadean ocean, were thought to house inorganic molecular machines. H+ flowed down the pH gradient (ΔpH) from ocean to vent ...
journal_title:Journal of molecular evolution
pub_type: 信件,评审
doi:10.1007/s00239-017-9805-9
更新日期:2017-08-01 00:00:00
abstract::The finding that ribozymes can catalyze RNA chain elongation has led to the proposal that an early self-replicating system could have consisted of RNA alone. In such a chain elongation reaction, the Tetrahymena ribozyme was found to select 3',5'-linked substrates from a pool that contained a large molar excess of 2',5...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02602919
更新日期:1989-12-01 00:00:00
abstract::We examined the nucleotide and amino acid sequence variation of the cytochrome c oxidase subunit II (COII) gene from 25 primates (4 hominoids, 8 Old World monkeys, 2 New World monkeys, 2 tarsiers, 7 lemuriforms, 2 lorisiforms). Marginal support was found for three phylogenetic conclusions: (1) sister-group relationshi...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00176084
更新日期:1994-03-01 00:00:00
abstract::Protamine P1 genes have been sequenced by PCR amplification and direct DNA sequencing from 9 primates representing 5 major families, Cebidae (new world monkeys), Cercopithecidae (old world monkeys), Hylobatidae (gibbons), Pongidae (gorilla, orangutan, and chimpanzee), and Hominidae (human). In this recently diverged g...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00178872
更新日期:1993-10-01 00:00:00
abstract::Ca(2+)/cation antiporter (CaCA) proteins are integral membrane proteins that transport Ca(2+) or other cations using the H(+) or Na(+) gradient generated by primary transporters. The CAX (for CAtion eXchanger) family is one of the five families that make up the CaCA superfamily. CAX genes have been found in bacteria, ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-006-0048-4
更新日期:2006-12-01 00:00:00
abstract::The mitochondrial cytochrome b (cyt-b) gene is widely used in systematic studies to resolve divergences at many taxonomic levels. The present study focuses mainly on the utility of cyt-b as a molecular marker for inferring phylogenetic relationship at various levels within the fish family Cichlidae. A total of 78 taxa...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s002390010197
更新日期:2001-08-01 00:00:00
abstract::The recent availability of genome sequences of four different Fusarium species offers the opportunity to perform extensive comparative analyses, in particular of repeated sequences. In a recent work, the overall content of such sequences in the genomes of three phylogenetically related Fusarium species, F. graminearum...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-011-9472-1
更新日期:2011-10-01 00:00:00
abstract::Complete chloroplast 23S rRNA and psbA genes from five peridinin-containing dinoflagellates (Heterocapsa pygmaea, Heterocapsa niei, Heterocapsa rotun-data, Amphidinium carterae, and Protoceratium reticulatum) were amplified by PCR and sequenced; partial sequences were obtained from Thoracosphaera heimii and Scrippsiel...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s002390010064
更新日期:2000-07-01 00:00:00
abstract::The PIGSFEAST (PF) exon of the Drosophila dumpy gene is undergoing concerted evolution by the process of unequal crossing over. We have developed a long-range PCR-based assay to amplify the approximately 12 kb long exon which contains variable numbers of 303 or 306 nt long repeats in a tandem array. We applied this pr...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-010-9327-1
更新日期:2010-03-01 00:00:00
abstract::Recombination has been suggested to be an important factor for the genetic variation of bacterial genes, but few studies have dealt with intragenic recombination between the same or closely related species of cyanobacteria. Here we provide strong evidence for recombination in the microcystin synthetase (mcy) gene clus...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-2583-1
更新日期:2004-06-01 00:00:00
abstract::Eight human short tandem repeat polymorphisms (STRs) also known as microsatellites-DYS19, DYS388, DYS390, DYS391, DYS392, DYS393, DYS389I, and DYS389II, mapping in the Y chromosome-were analyzed in two Iberian samples (Basques and Catalans). Allele frequency distributions showed significant differences only for DYS392...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006229
更新日期:1997-09-01 00:00:00
abstract::Response regulators of bacterial sensory transduction systems generally consist of receiver module domains covalently linked to effector domains. The effector domains include DNA binding and/or catalytic units that are regulated by sensor kinase-catalyzed aspartyl phosphorylation within their receiver modules. Most re...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00167109
更新日期:1995-02-01 00:00:00
abstract::Multiple phospholipase A2 (PLA2) isoenzymes found in a single snake venom induce a variety of pharmacological effects. These multiple forms are formed by gene duplication and accelerated evolution of exons. We examined the amino acid sequences of 127 snake venom PLA2 enzymes and their homologues to study in which loca...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006450
更新日期:1999-02-01 00:00:00
abstract::One of the key problems in the study of ancient DNA is that of authenticating sequences obtained from PCR amplifications of highly degraded samples. Contamination of ancient samples and postmortem damage to endogenous DNA templates are the major obstacles facing researchers in this task. In particular, the authenticat...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-006-0259-8
更新日期:2007-07-01 00:00:00
abstract::A general correlation between neural expression and negative charge in isozymes suggests charge represents an adaptation to the neural environment. Interestingly, a notable exception exists in teleost fish. Two cytosolic malate dehydrogenase (MDH) isozymes have different spatial expression patterns in certain fishes: ...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-002-2398-x
更新日期:2003-03-01 00:00:00
abstract::Nuclear DNA contents were estimated by microdensitometry in five species of Akodon rodents: Arodon molinae, A. dolores, A. mollis, A. azarae, Bolomys obscurus) and in three chromosomal varieties of A. molinae (2n = 42; 2n = 43, 2n = 22). The data obtained showed that the species with the highest DNA content was B. obs...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101640
更新日期:1983-01-01 00:00:00
abstract::This study investigated the evolution of a transition metal ion-binding cluster ([H--X--X--X--H](n); Tx) in the alternatively spliced NH(2)-terminal variable region of avian pectoral muscle troponin T (TnT). Encoded by avian fast skeletal muscle TnT-specific P exons, Tx-like structures were expressed in the breast mus...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s002390010139
更新日期:2001-02-01 00:00:00
abstract::Computational analysis of the hypothetical open reading frame MJ0236 from Methanococcus jannaschii reveals its membership to a family of bacterial and eukaryotic proteins, predicted to be the HMP-P kinases involved in thiamin biosyntheis (ThiD). The eukaryotic members of this family contain a C-terminal extension simi...
journal_title:Journal of molecular evolution
pub_type: 信件
doi:10.1007/pl00013145
更新日期:1997-12-01 00:00:00
abstract::Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (subst...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00182392
更新日期:1992-02-01 00:00:00
abstract::The nucleotide sequences of 5S rRNAs from three protozoa, Bresslaua vorax, Euplotes woodruffi and Chlamydomonas sp. have been determined and aligned together with the sequences of 12 protozoa species including unicellular green algae already reported by the authors and others. Using this alignment, a phylogenic tree o...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102316
更新日期:1983-01-01 00:00:00
abstract::Phylogenetic relationships among eight species of the Drosophila buzzatii species complex (D. mulleri subgroup; D. repleta species group) and D. hamatofila were determined by sequencing the mitochondrial cytochrome oxidase subunit I, II, and III genes. The species examined included members of the martensis cluster (D....
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00173155
更新日期:1995-12-01 00:00:00
abstract::Phospholipid vesicles (liposomes) were subjected to dehydration-hydration cycles in the presence of 6-carboxyfluorescein or salmon sperm DNA. We found that the vesicles fused into multilamellar structures during dehydration with solutes trapped between the lamellae. Upon rehydration the lamellae swelled and formed lar...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01733047
更新日期:1982-01-01 00:00:00
abstract::Many proteins exhibit sequence periodicity, often correlated with a visible structural periodicity. The statistical significance of such periodicity can be assessed by means of a chi-squared-based test, with significance thresholds being calculated from shuffled sequences. Comparison of the complete proteomes of 45 sp...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-0189-2
更新日期:2005-04-01 00:00:00
abstract::The evolutionary speed and the consequent immune escape of H3N2 influenza A virus make it an interesting evolutionary system. Charged amino acid residues are often significant contributors to the free energy of binding for protein-protein interactions, including antibody-antigen binding and ligand-receptor binding. We...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-010-9405-4
更新日期:2011-01-01 00:00:00
abstract::In this paper we present a new method for detecting block duplications in a genome. It is more stringent than previous ones in that it requires a more rigorous definition of paralogous genes and that it requires the paralogous proteins on the two blocks to be contiguous. In addition, it provides three criterion choice...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-002-2377-2
更新日期:2003-01-01 00:00:00
abstract::Frugivorous and nectarivorous bats rely largely on hepatic glycogenesis and glycogenolysis for postprandial blood glucose disposal and maintenance of glucose homeostasis during short time starvation, respectively. The glycogen synthase 2 encoded by the Gys2 gene plays a critical role in liver glycogen synthesis. To te...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-013-9600-1
更新日期:2014-01-01 00:00:00
abstract::The gas chromatograph mass spectrometer instrument of the Viking mission has demonstrated the absence of organic compounds in the immediate surface layer of the two landing sites. The demonstration of the successful operation of the instrument (comparison of ground-based test data with those obtained during interplane...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01732368
更新日期:1979-12-01 00:00:00
abstract::Algae are a heterogeneous group of photosynthetic eukaryotes traditionally separated into three major subdivisions: rhodophytes, chlorophytes, and chromophytes. The evolutionary origin of rhodophytes or red algae and their links to other photosynthetic and nonphotosynthetic eukaryotes have been a matter of much contro...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00163149
更新日期:1994-04-01 00:00:00
abstract::Drosophilidae is a large, widely distributed family of Diptera including 61 genera, of which Drosophila is the most representative. Drosophila feeding is part of the saprophytic trophic chain, because of its dependence upon decomposing organic matter. Many species have adapted to fermenting fruit feeding or to artific...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006378
更新日期:1998-08-01 00:00:00
abstract::The glycosylation characteristics of the digestive enzyme ribonuclease are summarized. The evolutionary role of this posttranslational modification is discussed and evidence is presented that selection has much influence on the presence or absence of carbohydrate in glycoproteins and on the positions of the carbohydra...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099959
更新日期:1986-01-01 00:00:00