Abstract：
:Members of the serpin (serine protease inhibitor) superfamily of genes are well represented in both human and murine genomes. In many cases it is possible to identify a definite ortholog on the basis of sequence similarity and by examining the surrounding genes at syntenic loci. We have recently examined the murine serpin locus at 12F1 and observed that the single human alpha1-antichymotrypsin gene is represented by 14 paralogs. It is also known that the single human alpha1-antitrypsin gene has five paralogs in the mouse. The forces driving this gene multiplication are unknown and there are no data describing the function of the various serpin gene products at the alpha1-antichymotrypsin multigene locus. Examination of the predicted amino acid sequences shows that the serpins are likely to be functional protease inhibitors but with differing target protease specificities. In order to begin to address the question of the problem presented by the murine alpha1-antichymotrypsins, we have used RT-PCR to examine the expression pattern of these serpin genes. Our data show that the divergent reactive center loop sequence, and predictably variable target protease specificity, is reflected in tissue-specific expression for many of the family members. These observations add weight to the hypothesis that the antichymotrypsin-like serpins have an evolutionary importance which has led to their expansion and diversification in multiple species.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Horvath AJ,Forsyth SL,Coughlin PBdoi
10.1007/s00239-004-2640-9keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
488-97issue
4eissn
0022-2844issn
1432-1432journal_volume
59pub_type
杂志文章abstract：:Cyclooxygenase (COX) enzymatically converts arachidonic acid into prostaglandin G/H in animals and has importance during pregnancy, digestion, and other physiological functions in mammals. COX genes have mainly been described from vertebrates, where gene duplications are common, but few studies have examined COX in in...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-015-9670-3
更新日期：2015-04-01 00:00:00
abstract：:We have implemented a routine procedure for screening protein sequences for evidence of intragenic duplications. We tested 163 protein sequences representing 116 superfamilies of unrelated proteins. Twenty superfamilies contain proteins with internal gene duplications. The intragenic duplications detected can be divid...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01734217
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01734358
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-004-0324-0
更新日期：2005-10-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02342746
更新日期：1991-03-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-003-2504-8
更新日期：2003-11-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02406723
更新日期：1993-05-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02099959
更新日期：1986-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02603114
更新日期：1987-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-006-0161-4
更新日期：2007-02-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-001-0040-y
更新日期：2002-05-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-010-9352-0
更新日期：2010-06-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-020-09977-7
更新日期：2020-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02111286
更新日期：1987-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-018-9876-2
更新日期：2018-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 信件
doi：10.1007/s00239-003-2496-4
更新日期：2003-10-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006427
更新日期：1998-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01653958
更新日期：1972-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-10-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00160314
更新日期：1995-10-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02100629
更新日期：1984-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01738882
更新日期：1976-06-23 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02603122
更新日期：1987-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01732356
更新日期：1975-11-04 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02407357
更新日期：1993-08-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-008-9166-5
更新日期：2008-11-01 00:00:00
