Abstract：
:Cytochrome proteins perform a broad spectrum of biological functions ranging from oxidative metabolism to electron transport and are thus essential to all organisms. The b-type cytochrome proteins bind heme noncovalently, are expressed in many different forms and are localized to various cellular compartments. We report the characterization of the cytochrome b5 (Cyt-b) gene of Drosophila virilis and compare its structure to the Cyt-b gene of Drosophila melanogaster. As in D. melanogaster, the D. virilis gene is nuclear encoded and single copy. Although the intron/exon structures of these homologues differ, the Cyt-b proteins of D. melanogaster and D. virilis are approximately 75% identical and share the same size coding regions (1,242 nucleotides) and protein products (414 amino acids). The Drosophila Cyt-b proteins show sequence similarity to other b-type cytochromes, especially in the N-terminal heme-binding domain, and may be targeted to the mitochondrial membrane. The greatest levels of similarity are observed in areas of potential importance for protein structure and function. The exon sequences of the D. virilis Cyt-b gene differ by a total of 292 base changes. However, 62% of these changes are silent. The high degree of conservation between species separated by 60 million years of evolution in both the DNA and amino acid sequences suggests this nuclear cytochrome b5 locus encodes an essential product of the Drosophila system.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Kula ME,Allay ER,Rozek CEdoi
10.1007/BF00160314subject
Has Abstractpub_date
1995-10-01 00:00:00pages
430-9issue
4eissn
0022-2844issn
1432-1432journal_volume
41pub_type
杂志文章abstract：:Prediction of the thermodynamic behaviors of biomolecules at high temperature and pressure is fundamental to understanding the role of hydrothermal systems in the origin and evolution of life on the primitive Earth. However, available thermodynamic dataset for amino acids, essential components for life, cannot represe...
journal_title：Journal of molecular evolution
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更新日期：2014-04-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1996-09-01 00:00:00
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
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更新日期：2016-05-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：1982-01-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：1999-06-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：1996-07-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1994-02-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006368
更新日期：1998-08-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02102316
更新日期：1983-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1977-12-29 00:00:00
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pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006391
更新日期：1998-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF02339009
更新日期：1996-10-01 00:00:00
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更新日期：1990-03-01 00:00:00
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更新日期：1998-03-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：1998-12-01 00:00:00
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更新日期：1999-11-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：2011-03-01 00:00:00
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journal_title：Journal of molecular evolution
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更新日期：1994-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1995-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：2007-09-01 00:00:00
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1990-02-01 00:00:00
