Abstract:
:We have implemented a routine procedure for screening protein sequences for evidence of intragenic duplications. We tested 163 protein sequences representing 116 superfamilies of unrelated proteins. Twenty superfamilies contain proteins with internal gene duplications. The intragenic duplications detected can be divided into two major types. (1) One or more duplications of all or part of a gene produce a protein with two or several detectable regions of sequence homology. Sequences from 18 superfamilies contained this type of duplication. (2) Repeated reduplication of a small DNA segment can produce a protein that is repetitive over most of its length. Three superfamilies contain such repetitive sequences. We also investigated the limits of detection of ancient duplications using sequences derived by random mutation of a model sequence consisting of ten 10-residue repeats. The original repetitive nature of the sequence was usually detected after 250 point mutations even though the ancestral segment could not be accurately reconstructed.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Barker WC,Ketcham LK,Dayhoff MOdoi
10.1007/BF01734217subject
Has Abstractpub_date
1978-02-21 00:00:00pages
265-81issue
4eissn
0022-2844issn
1432-1432journal_volume
10pub_type
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