Abstract:
:Tests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino acids, resulting in increased fitness in the species. Recently, a few methods have been developed to detect and characterize directional selection on a molecular level. Using the results of evolutionary simulations as well as HIV drug resistance data as models of directional selection, we compare two such methods with each other, as well as against a standard method for detecting diversifying selection. We find that the method to detect diversifying selection also detects directional selection under certain conditions. One method developed for detecting directional selection is powerful and accurate for a wide range of conditions, while the other can generate an excessive number of false positives.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Thiltgen G,Dos Reis M,Goldstein RAdoi
10.1007/s00239-016-9765-5subject
Has Abstractpub_date
2017-01-01 00:00:00pages
39-50issue
1eissn
0022-2844issn
1432-1432pii
10.1007/s00239-016-9765-5journal_volume
84pub_type
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-005-0187-z
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006378
更新日期:1998-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-05-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-007-9062-4
更新日期:2008-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00166248
更新日期:1993-02-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101000
更新日期:1986-01-01 00:00:00
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02602919
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02337352
更新日期:1996-08-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
abstract::Seven new Italian and two new British HTLV-II isolates were obtained from injecting drug users and the entire long terminal repeat (LTR) region was sequenced. Restriction analysis showed that all the Italian isolates are of the IIb subtype, whereas the British isolates are of the IIa subtype. To understand whether the...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006340
更新日期:1998-05-01 00:00:00
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
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