Abstract:
:Insertions and deletions of entire codons have recently been discovered as a mechanism by which B cells, in addition to conventional base substitution, evolve the antibodies produced by their immunoglobulin genes. These events frequently seem to involve repetitive sequence motifs in the antibody-encoding genes, and it has been suggested that they occur through polymerase slippage. In order to better understand the process of codon deletion, we have analyzed the human immunoglobulin heavy variable (IGHV) germline gene repertoire for the presence of trinucleotide repeats. Such repeats would ensure that the reading frame is maintained in the case of a deletional event, as slippage over multiples of three bases would be favored. We demonstrate here that IGHV genes specifically carry repetitive trinucleotide motifs in the complementarity-determining regions (CDR) 1 and 2, thus making these parts of the genes that encode highly flexible structures particularly prone to functional deletions. We propose that the human IGHV repertoire carries inherent motifs that allow an antibody response to develop efficiently by targeting codon deletion events to the parts of the molecule that are likely to be able to harbor such modifications.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Lantto J,Ohlin Mdoi
10.1007/s00239-001-0049-2keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
346-53issue
3eissn
0022-2844issn
1432-1432journal_volume
54pub_type
杂志文章abstract::This study dealt with the ability of non-denaturing gel electrophoresis to separate iso-1-cytochrome c with single amino acid replacements isolated from revertants of various cyc1 nonsense mutants of the yeast Saccharomyces cerevisiae. A total of 28 different iso-1-cytochromes c with single amino acid substitutions of...
journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01732868
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-005-0102-7
更新日期:2005-12-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00171820
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00166162
更新日期:1994-02-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01734217
更新日期:1978-02-21 00:00:00
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doi:10.1007/s00239-003-2543-1
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
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更新日期:1980-08-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101983
更新日期:1984-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02102187
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02109481
更新日期:1990-08-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00