Abstract:
:Protamine P1 genes have been sequenced following PCR amplification from 11 mammals representing five major mammalian orders: Rodentia (rat and guinea pig), Carnivora (cat and bear), Proboscidea (elephant), Perissodactyla (horse), and Artiodactyla (camel, deer, elk, moose, and gazelle). The predicted amino acid sequence for these genes together with previously reported sequences results in a data set of 25 different P1 genes and 30 different P1 amino acid sequences. The alignment of all these sequences reveals that protamines are amongst the most rapidly diverging proteins studied. In spite of the large number of differences there are conserved motifs that are also common to birds such as the N-terminal ARYR followed by the triple alternating SRSRSR phosphorylation site. The central region contains 3 arginine clusters consisting of 5-6 arginines each. The C-terminus appears to be the most variable region of the protamines. Overall the molecular evolution of P1 genes is in agreement with the expected species evolution supporting that these genes have evolved vertically.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Queralt R,Adroer R,Oliva R,Winkfein RJ,Retief JD,Dixon GHdoi
10.1007/BF00160507subject
Has Abstractpub_date
1995-06-01 00:00:00pages
601-7issue
6eissn
0022-2844issn
1432-1432journal_volume
40pub_type
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