Oligonucleotide formation catalyzed by divalent metal ions. The uniqueness of the ribosyl system.

abstract：:Proteins are commonly used as molecular targets against pathogens such as viruses and bacteria. However, pathogens can evolve rapidly permitting their populations to increase in protein diversity over time and thus escape to the activity of a molecular therapy. Subsequently, in order to design more durable and robust ...

journal_title：Journal of molecular evolution

authors： Arenas M

更新日期：2020-08-01 00:00:00

abstract：:There have been two distinct phases of evolution of the genetic code: an ancient phase--prior to the divergence of the three domains of life, during which the standard genetic code was established--and a modern phase, in which many alternative codes have arisen in specific groups of genomes that differ only slightly f...

journal_title：Journal of molecular evolution

authors： Sengupta S,Higgs PG

更新日期：2015-06-01 00:00:00

abstract：:It is generally considered that if an RNA World ever existed that it would be driven by an RNA capable of RNA replication. Whether such a catalytic RNA could emerge in an RNA World or not, there would need to be prior routes to increasing complexity in order to produce it. It is hypothesized here that increasing seque...

journal_title：Journal of molecular evolution

authors： Tirumalai MR,Tran Q,Paci M,Chavan D,Marathe A,Fox GE

更新日期：2018-06-01 00:00:00

abstract：:The NF-κB family of transcription factors is activated in response to many environmental and biological stresses, and plays a key role in innate immunity across a broad evolutionary expanse of animals. A simple NF-κB pathway is present in the sea anemone Nematostella vectensis, an important model organism in the phylu...

journal_title：Journal of molecular evolution

authors： Wolenski FS,Chandani S,Stefanik DJ,Jiang N,Chu E,Finnerty JR,Gilmore TD

更新日期：2011-12-01 00:00:00

abstract：:Prediction of the thermodynamic behaviors of biomolecules at high temperature and pressure is fundamental to understanding the role of hydrothermal systems in the origin and evolution of life on the primitive Earth. However, available thermodynamic dataset for amino acids, essential components for life, cannot represe...

journal_title：Journal of molecular evolution

authors： Kitadai N

更新日期：2014-04-01 00:00:00

abstract：:We have sequenced the nuclear and mitochondrial small subunit rRNA genes (rns) and the mitochondrial genes coding for subunits 1 and 3 of the cytochrome oxidase (cox1 and cox3, respectively) of the chytridiomycete Allomyces macrogynus. Phylogenetic trees inferred from the derived COX1 and COX3 proteins and the nuclear...

journal_title：Journal of molecular evolution

authors： Paquin B,Forget L,Roewer I,Lang BF

更新日期：1995-11-01 00:00:00

abstract：:Hypoxia at deep-sea hydrothermal vents represents one of the most basic challenges for metazoans, which then requires specific adaptations to acquire oxygen to meet their metabolic needs. Hydrothermal vent scale-worms (Polychaeta; Polynoidae) express large amounts of extracellular single- and multi-domain hemoglobins,...

journal_title：Journal of molecular evolution

authors： Projecto-Garcia J,Le Port AS,Govindji T,Jollivet D,Schaeffer SW,Hourdez S

更新日期：2017-12-01 00:00:00

abstract：:It is known that globin genes contain three exons with the middle exon coding for a four-helical supersecondary structure responsible for heme binding. Since this portion of the globin peptide chain can be structurally superimposed onto the cytochrome c and cytochrome b5 chains (Argos and Rossmann 1979), it can be inf...

journal_title：Journal of molecular evolution

authors： Argos P,Rossmann MG

更新日期：1980-12-01 00:00:00

abstract：:In the previous three reports in this series we demonstrated that the EF-hand family of proteins evolved by a complex pattern of gene duplication, transposition, and splicing. The dendrograms based on exon sequences are nearly identical to those based on protein sequences for troponin C, the essential light chain myos...

journal_title：Journal of molecular evolution

authors： Kretsinger RH,Nakayama S

更新日期：1993-05-01 00:00:00

abstract：:As illustrated by the mitochondrion and the eukaryotic cell, little in biology makes sense except in light of mutualism. Mutualisms are persistent, intimate, and reciprocal exchanges; an organism proficient in obtaining certain benefits confers those on a partner, which reciprocates by conferring different benefits. M...

journal_title：Journal of molecular evolution

authors： Lanier KA,Petrov AS,Williams LD

更新日期：2017-08-01 00:00:00

abstract：:The mitochondrial genetic variability in European rabbit (Oryctolagus cuniculus) populations present in Europe and North Africa from 11,000 years ago to the present day has been analyzed using ancient DNA techniques. DNA was extracted from 90 rabbit bones found in 22 archaeological sites dated between the Mesolithic a...

journal_title：Journal of molecular evolution

authors： Hardy C,Callou C,Vigne JD,Casane D,Dennebouy N,Mounolou JC,Monnerot M

更新日期：1995-03-01 00:00:00

abstract：:A major goal of evolutionary biology is to understand how beneficial mutations translate into increased fitness. Here, we study beneficial mutations that arise in experimental populations of yeast evolved in glucose-rich media. We find that fitness increases are caused by enhanced maximum growth rate (R) that come at ...

journal_title：Journal of molecular evolution

authors： Sezmis AL,Malerba ME,Marshall DJ,McDonald MJ

更新日期：2018-02-01 00:00:00

abstract：:EcoRI restriction of the B. nigra rDNA recombinants, isolated from a lambda genomic library, showed that the 3.9-kb fragment corresponded to the Intergenic Spacer (IGS), which was sequenced and found to be 3,928 bp in size. Sequence and dot-matrix analyses showed that the organization of the B. nigra rDNA IGS was typi...

journal_title：Journal of molecular evolution

authors： Bhatia S,Singh Negi M,Lakshmikumaran M

更新日期：1996-11-01 00:00:00

abstract：:All complete retrovirus sequences in the GenEMBL database were examined with the goal of assessing possible relationships between the nucleotide composition of retroviral genomes, the amino acid composition of retroviral proteins, and evolutionary strategies used by retroviruses. The results demonstrated that the geno...

journal_title：Journal of molecular evolution

authors： Bronson EC,Anderson JN

更新日期：1994-05-01 00:00:00

abstract：:Langley and Fitch (1974, 1976) have shown that the pattern of nucleotide substitutions in proteins is inconsistent with a Poisson process with constant rate. From this they conclude that the rate is temporally heterogeneous. It is pointed out in this note that a process which is temporally homogeneous but not a Poisso...

journal_title：Journal of molecular evolution

authors： Gillespie JH,Langley CH

更新日期：1979-06-08 00:00:00

abstract：:Catalyzed by a family of enzymes called glycosyltransferases, glycosylation reactions are essential for the bioactivities of secondary metabolites such as antibiotics. Due to the special characters of antibiotic glycosyltransferases (AGts), antibiotics can function by attaching some unusual deoxy-sugars to their aglyc...

journal_title：Journal of molecular evolution

authors： Liang D,Qiao J

更新日期：2007-03-01 00:00:00

abstract：:The LMP7 and PSMB5 genes were created through an ancient gene duplication event of their ancestral locus. These proteins contain an active site of proteolysis, and LMP7 replaces PSMB5 as a component of the 20S proteasome after stimulation of cells by interferon-gamma. Replacement of PSMB5 by LMP7 changes the profile o...

journal_title：Journal of molecular evolution

authors： Bos DH

更新日期：2005-02-01 00:00:00

abstract：:Many eubacteria contain an ATP-dependent protease complex, which is built by multiple copies of the HslV and HslU proteins and is therefore called HslVU. HslU proteins are AAA + ATPases, while HslV proteins are proteases that show highly significant similarity to beta subunits of proteasomes. Therefore, the HslVU comp...

journal_title：Journal of molecular evolution

authors： Ruiz-González MX,Marín I

更新日期：2006-10-01 00:00:00

abstract：:The finding that ribozymes can catalyze RNA chain elongation has led to the proposal that an early self-replicating system could have consisted of RNA alone. In such a chain elongation reaction, the Tetrahymena ribozyme was found to select 3',5'-linked substrates from a pool that contained a large molar excess of 2',5...

journal_title：Journal of molecular evolution

authors： Young B,Cech TR

更新日期：1989-12-01 00:00:00

abstract：:Gene duplication by retrotransposition duplicates only the coding and untranslated regions of a gene and, thus, biases retroduplicated genes toward having different expression patterns from their parental genes. As such, genes duplicated by retrotransposition are more likely to develop novel expression domains. To exp...

journal_title：Journal of molecular evolution

authors： Penney J,Bossé J,Clark DV

更新日期：2008-05-01 00:00:00

abstract：:Studies so far have correlated the variation in the composition of snake venoms with the target prey population and snake's diet. Here we present the first example of an alternative evolutionary link between venom composition and dietary adaptation of snakes. We describe a dinucleotide deletion in the only three finge...

journal_title：Journal of molecular evolution

authors： Li M,Fry BG,Kini RM

更新日期：2005-01-01 00:00:00

abstract：:Introns are generally believed to evolve too rapidly and too erratically to be of much use in phylogenetic reconstructions. Few phylogenetically informative intron sequences are available, however, to ascertain the validity of this supposition. In the present study the supposition was tested on the example of the mamm...

journal_title：Journal of molecular evolution

authors： Kupfermann H,Satta Y,Takahata N,Tichy H,Klein J

更新日期：1999-06-01 00:00:00

abstract：:Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (subst...

journal_title：Journal of molecular evolution

authors： Lockhart PJ,Howe CJ,Bryant DA,Beanland TJ,Larkum AW

更新日期：1992-02-01 00:00:00

abstract：:Alu elements are not distributed homogeneously throughout the human genome: old elements are preferentially found in the GC-rich parts of the genome, while young Alus are more often found in the GC-poor parts of the genome. The process giving rise to this differential distribution remains poorly understood. Here we in...

journal_title：Journal of molecular evolution

authors： Belle EM,Webster MT,Eyre-Walker A

更新日期：2005-03-01 00:00:00

abstract：:An assay based on derivative analysis of thermal denaturation (melting) behavior of reassociated DNA was developed in an attempt to characterize the sequence relationships in repeated DNA families according to the homogeneous or heterogeneous models of Bendich and Anderson (1977). The validity of the technique was con...

journal_title：Journal of molecular evolution

authors： Preisler RS,Thompson WF

更新日期：1981-01-01 00:00:00

abstract：:The usage of synonymous codons and the frequencies of amino acids were investigated in the complete genome of the bacterium Thermotoga maritima using a multivariate statistical approach. The GC3 content of each gene was the most prominent source of variation of codon usage. Surprisingly the usage of UGU and UGC (synon...

journal_title：Journal of molecular evolution

authors： Zavala A,Naya H,Romero H,Musto H

更新日期：2002-05-01 00:00:00

abstract：:We recently sequenced the genome of the first subterrestrial metazoan, the nematode Halicephalobus mephisto. A central finding was a dramatic expansion of genes encoding avrRpt2 induced gene (AIG1), and 70 kDa heat shock (Hsp70) domains. While the role of Hsp70 in thermotolerance is well established, the contribution ...

journal_title：Journal of molecular evolution

authors： Guerin MN,Weinstein DJ,Bracht JR

更新日期：2019-12-01 00:00:00

abstract：:The dominant paradigm in origin of life research is that of an RNA world. However, despite experimental progress towards the spontaneous formation of RNA, the RNA world hypothesis still has its problems. Here, we introduce a novel computational model of chemical reaction networks based on RNA secondary structure and a...

journal_title：Journal of molecular evolution

authors： Hordijk W

更新日期：2017-04-01 00:00:00

abstract：:Barnacles (Cirripedia) are a subclass of Crustacea. Their peculiar segmentation pattern (few segments, absence of abdominal segments, and, in the parasitic rhizocephalan, loss of segmentation at the adult stage) prompted us to study the engrailed gene, which encodes a homeodomain transcription factor and is expressed ...

journal_title：Journal of molecular evolution

authors： Gibert JM,Mouchel-Vielh E,Deutsch JS

更新日期：1997-06-01 00:00:00

abstract：:Computational and experimental attempts tried to characterize a universal core of genes representing the minimal set of functional needs for an organism. Based on the increasing number of available complete genomes, comparative genomics has concluded that the universal core contains < 50 genes. In contrast, experiment...

journal_title：Journal of molecular evolution

authors： Carbone A

更新日期：2006-12-01 00:00:00