Toward assigning helical regions in alignments of ribosomal RNA and testing the appropriateness of evolutionary models.

Abstract:

:We suggest a nucleotide substitution model that takes correlation between base-paired nucleotides into account. The model includes the estimation of the transition-transversion ratio and allows inference of the shape parameter of a discrete gamma distribution to include rate heterogeneity. A Cox-test statistic, applied to a diatom ribosomal RNA alignment, shows that the suggested correlation model explains evolution of the stem region better than usual independence models. Moreover, the Cox-test procedure is extended to shed some light upon the problem of assigning helical regions in a secondary structure based alignment. This approach provides an estimate of the percentage of stem positions that do not appear to be correlated.

journal_name

J Mol Evol

authors

Schöniger M,von Haeseler A

doi

10.1007/pl00006590

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

691-8

issue

5

eissn

0022-2844

issn

1432-1432

pii

JME1937

journal_volume

49

pub_type

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