Abstract：
:The nearly neutral theory attributes most nucleotide substitution and polymorphism to genetic drift acting on weakly selected mutants, and assumes that the selection coefficients for these mutants are drawn from a continuous distribution. This means that parameter estimation can require numerical integration, and this can be computationally costly and inaccurate. Furthermore, the leading parameter dependencies of important quantities can be unclear, making results difficult to understand. For some commonly used distributions of mutant effects, we show how these problems can be avoided by writing equations in terms of special functions. Series expansion then allows for their rapid calculation and, also, illuminates leading parameter dependencies. For example, we show that if mutants are gamma distributed, the neutrality index is largely independent of the effective population size. However, we also show that such results are not robust to misspecification of the functional form of distribution. Some implications of these findings are then discussed.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Welch JJ,Eyre-Walker A,Waxman Ddoi
10.1007/s00239-008-9146-9subject
Has Abstractpub_date
2008-10-01 00:00:00pages
418-26issue
4eissn
0022-2844issn
1432-1432journal_volume
67pub_type
杂志文章abstract：:Algae are a heterogeneous group of photosynthetic eukaryotes traditionally separated into three major subdivisions: rhodophytes, chlorophytes, and chromophytes. The evolutionary origin of rhodophytes or red algae and their links to other photosynthetic and nonphotosynthetic eukaryotes have been a matter of much contro...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00163149
更新日期：1994-04-01 00:00:00
abstract：:Catalyzed polymerization reactions represent a primary anabolic activity of all cells. It can be assumed that early cells carried out such reactions, in which macromolecular catalysts were encapsulated within some type of boundary membrane. In the experiments described here, we show that a template-independent RNA pol...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00160400
更新日期：1994-12-01 00:00:00
abstract：:The glycosylation characteristics of the digestive enzyme ribonuclease are summarized. The evolutionary role of this posttranslational modification is discussed and evidence is presented that selection has much influence on the presence or absence of carbohydrate in glycoproteins and on the positions of the carbohydra...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02099959
更新日期：1986-01-01 00:00:00
abstract：:Gene duplication by retrotransposition duplicates only the coding and untranslated regions of a gene and, thus, biases retroduplicated genes toward having different expression patterns from their parental genes. As such, genes duplicated by retrotransposition are more likely to develop novel expression domains. To exp...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-008-9098-0
更新日期：2008-05-01 00:00:00
abstract：:Liverworts are well supported as the sister group to all other land plants (embryophytes) by molecular data. Observations strongly supporting this earliest dichotomy in embryophyte evolution are the strikingly different introns occurring in the mitochondrial DNAs of liverworts versus non-liverwort embryophytes (NLE), ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-010-9348-9
更新日期：2010-05-01 00:00:00
abstract：:In studies of molecular evolution, the assumption that protein evolution is reversible has often been made, but rarely tested. Here we use a large set of orthologous murid protein coding sequences to perform a simple test of reversibility, and find no evidence to reject the assumption of reversibility in protein evolu...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s002390010176
更新日期：2001-05-01 00:00:00
abstract：:The sequences of the adenylate kinase gene (adk) and the RecA gene (recA) were determined from the same isolates of Neisseria gonorrhoeae, N. meningitidis, N. lactamica, N. polysaccharea, N. cinerea, N. mucosa, N. pharyngis var. flava, N. flavescens, and N. animalis. The patterns of sequence divergence observed at adk...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02202111
更新日期：1996-12-01 00:00:00
abstract：:The first intron of the gene encoding one of the alcohol dehydrogenase isoenzymes (ADH-1) in Ceratitis capitata is highly polymorphic in size. Five size variants of this intron were isolated from different strains and populations and characterized. Restriction map and sequence analysis showed that the intron size poly...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-004-2596-9
更新日期：2004-06-01 00:00:00
abstract：:DEAD-box proteins are found in all domains of life and participate in almost all cellular processes that involve RNA. The presence of DEAD and Helicase_C conserved domains distinguish these proteins. DEAD-box proteins exhibit RNA-dependent ATPase activity in vitro, and several also show RNA helicase activity. In this ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-011-9441-8
更新日期：2011-04-01 00:00:00
abstract：:The in vitro expression of two distinct proteins from overlapping reading frames in a sequence of rainbow trout genomic DNA has been demonstrated. In vitro transcription of DNA sequences, cloned in a plasmid under the control of Salmonella phage 6 polymerase promoter, led to the synthesis of two distinct and functiona...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02099952
更新日期：1986-01-01 00:00:00
abstract：:Two types of gene encoding small subunits (SSU) of ADP-glucose pyrophosphorylase, a starch-biosynthetic enzyme, have been found in cereals and other grasses. One of these genes encodes two SSU proteins. These are targeted to different subcellular compartments and expressed in different organs of the plant: the endospe...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-007-9013-0
更新日期：2007-09-01 00:00:00
abstract：:There has been considerable discussion in recent years on the evolution of the tandemly repeated multigene families, since some organisms show a concerted model whereas others show a birth-and-death model. This controversial subject extends to several species of fish. In this study, three species of the Sparidae famil...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-013-9541-8
更新日期：2013-03-01 00:00:00
abstract：:While studies of the evolutionary histories of protein families are commonplace, little is known on noncoding RNAs beyond microRNAs and some snoRNAs. Here we investigate in detail the evolutionary history of the nine spliceosomal snRNA families (U1, U2, U4, U5, U6, U11, U12, U4atac, and U6atac) across the completely o...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-008-9149-6
更新日期：2008-12-01 00:00:00
abstract：:The beta-globin gene cluster of Wistar rat was extensively cloned and the embryonic genes were mapped and sequenced. Four overlapping lambda Dash recombinant clones cover about 31 kb and contain four nonadult beta-globin genes, 5'-epsilon1-gamma1-gamma2-psigamma3-3'. The epsilon1 and gamma2 are active genes, since the...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006525
更新日期：1999-07-01 00:00:00
abstract：:The complete or partial sequences of 47 E. coli ribosomal proteins described in the literature have been examined by computerized search and matching programs. In contrast to results previously reported by other investigators, sequence homologies were uncovered among some of these ribosomal proteins that are well beyo...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF01732666
更新日期：1980-05-01 00:00:00
abstract：:We describe the complete mitochondrial genome of the house centipede Scutigera coleoptrata. Its gene order is unique among characterized arthropod mitochondrial genomes. Comparison to the gene order in the horseshoe crab mtDNA implies 10 or more translocations. By extending comparisons to 30 arthropod mitochondrial ge...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-003-2563-x
更新日期：2004-04-01 00:00:00
abstract：:Spermatogenesis is one of the most complex biological processes undergone by any organism, making it susceptible to perturbations that result in male sterility. Research has demonstrated that mutant phenotypes can be obtained from the disruption of epigenetic modifications, which are commonly microRNA guided. Employin...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-011-9478-8
更新日期：2011-12-01 00:00:00
abstract：:Previous studies have revealed a major difference in the phylogenetic structure, extent of genetic diversity, and selection pressure between the surface glycoproteins and internal gene segments of avian influenza viruses (AIV) sampled from wild birds. However, what evolutionary processes are responsible for these stri...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-009-9312-8
更新日期：2010-01-01 00:00:00
abstract：:Low oxygen and fluctuant ambient temperature pose serious challenges to mammalian survival. Physiological adaptations in mammals to hypoxia and low temperatures have been intensively investigated, yet their underlying molecular mechanisms need further exploration. Independent invasions of high-altitude plateaus, subte...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-018-9870-8
更新日期：2018-12-01 00:00:00
abstract：:An exhaustive computer-assisted analysis of the Moloney murine leukemia virus nucleotide sequence shows numerous deviations in the oligomeric distribution, suggesting three overlapping levels of a stepwise duplicative evolution. (1) The sequence fits the universal rule of TG/CT excess which has been proposed as the co...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00171820
更新日期：1992-11-01 00:00:00
abstract：:A general correlation between neural expression and negative charge in isozymes suggests charge represents an adaptation to the neural environment. Interestingly, a notable exception exists in teleost fish. Two cytosolic malate dehydrogenase (MDH) isozymes have different spatial expression patterns in certain fishes: ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-002-2398-x
更新日期：2003-03-01 00:00:00
abstract：:Sequence data from regions of five vertebrate vitellogenin genes were used to examine the frequency, distribution, and mutability of the dinucleotide CpG, the preferred modification site for eukaryotic DNA methyltransferases. The observed level of the CpG dinucleotide in all five genes was markedly lower than that exp...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02101752
更新日期：1987-01-01 00:00:00
abstract：:We report the sequence of A/B.L1, a tightly linked pair of genes from the A and B chorion families in Bombyx mori. Comparison with the previously characterized A/B.L11 and A/B.L12 pairs from the same species reveals moderate sequence divergence, which is clearly nonuniform. Although the average divergence of A/B.L12 f...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02602909
更新日期：1989-11-01 00:00:00
abstract：:Protamine P1 genes have been sequenced following PCR amplification from 11 mammals representing five major mammalian orders: Rodentia (rat and guinea pig), Carnivora (cat and bear), Proboscidea (elephant), Perissodactyla (horse), and Artiodactyla (camel, deer, elk, moose, and gazelle). The predicted amino acid sequenc...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00160507
更新日期：1995-06-01 00:00:00
abstract：:From the cloned mitochondrial DNAs (mtDNAs) isolated from two bisexual species, one Mediterranean, Artemia salina, and one American, Artemia franciscana, and two parthenogenetic (diploid and tetraploid) strains of Artemia parthenogenetica collected in Spain, physical maps have been constructed and compared. They are e...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00166162
更新日期：1994-02-01 00:00:00
abstract：:Fish protamines are highly specialized molecules which are responsible for chromatin condensation during the last stages of spermatogenesis (spermiogenesis). However, not all fish contain protamines in their sperm nuclei; rather, there seems to be a random distribution of protamines within this group. The origin of th...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00160152
更新日期：1994-09-01 00:00:00
abstract：:Abortive cycling features transcription initiation by RNA polymerase in both prokaryote and eukaryote. It is known that T7 RNA polymerase produces abortive transcripts up to eight ribonucleotides in length depending on the initial sequence of the DNA message. On the other hand, T7 RNA polymerase initiates DNA replicat...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF00160407
更新日期：1994-12-01 00:00:00
abstract：:The nucleotide sequences of 5S rRNAs from three protozoa, Bresslaua vorax, Euplotes woodruffi and Chlamydomonas sp. have been determined and aligned together with the sequences of 12 protozoa species including unicellular green algae already reported by the authors and others. Using this alignment, a phylogenic tree o...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/BF02102316
更新日期：1983-01-01 00:00:00
abstract：:Throughout history, remote archipelagos have repeatedly been designated natural laboratories to study evolutionary processes. The extensive, geographically structured, morphological variation within Galápagos' Opuntia cacti has been presumed to be another example of how such processes shape diversity. However, recent ...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/s00239-011-9434-7
更新日期：2011-03-01 00:00:00
abstract：:It has recently been argued that living metazoans diverged over 800 million years ago, based on evidence from 22 nuclear genes for such a deep divergence between vertebrates and arthropods (Gu 1998). Two "internal" calibration points were used. However, only one fossil divergence date (the mammal-bird split) was direc...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
doi：10.1007/pl00006562
更新日期：1999-09-01 00:00:00
