Abstract:
:Only mammals have relinquished parthenogenesis as a means of producing descendants. Bi-parental reproduction is necessary due to parent-specific epigenetic modification of the genome during gametogenesis, which leads to non-equivalent expression of imprinted genes from the maternal and paternal alleles. However, a series of our work showed that alteration of maternal imprinting by oocyte reconstruction using non-growing oocytes, together with deletion of the H19 gene provide appropriate expression of imprinted genes from the maternal genome. The resulting ng (non-growing)/fg (fully-grown) parthenogenic embryos were developed to term. Here, we discuss how the parthenogenetic embryos survived as normal individuals.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Kono Tdoi
10.1159/000090812keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
31-5issue
1-4eissn
1424-8581issn
1424-859Xpii
90812journal_volume
113pub_type
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