Abstract:
:KLF13 and FGFR3 have important cellular functions and each is believed to play a role in cancer. KLF13 is a transcription factor required for the expression of several oncogenes. FGFR3 is a fibroblast growth factor receptor that initiates a signaling cascade leading to the activation of numerous cellular pathways. Here we show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cancer cells and may be useful biomarkers for early detection and possible targets for therapy.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Henson BJ,Gollin SMdoi
10.1159/000308303subject
Has Abstractpub_date
2010-06-01 00:00:00pages
192-8issue
4eissn
1424-8581issn
1424-859Xpii
000308303journal_volume
128pub_type
杂志文章abstract::Nonmosaic trisomy involving 19p13.3p13.2 is a very uncommon abnormality. At present, only 12 cases with this genetic condition have been reported in the literature. However, the size of the trisomic fragment is heterogeneous and thus, the clinical spectrum is variable. Herein, we report the clinical and cytogenetic ch...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000507561
更新日期:2020-01-01 00:00:00
abstract::Transposable elements (TE) constitute one of the most variable genomic features among vertebrates, impacting genome size, structure, and composition. Despite their important role in shaping genomic diversity, they have mostly been studied in mammals, which display one of the least diverse genomes in terms of TE divers...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000496416
更新日期:2019-01-01 00:00:00
abstract::Genets (Genetta) are a genus of African mammalian carnivorans with 14 currently recognized species, although taxonomic uncertainties remain, particularly regarding the number of species within the large-spotted genet complex. This study presents the first banded karyotype and molecular cytogenetic analysis of a geneti...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000450627
更新日期:2016-01-01 00:00:00
abstract::Cytogenetic investigations performed in eight Portuguese cattle breeds revealed the presence of rob(1;29) in both heterozygous and homozygous conditions in all, and five breeds, respectively, with variable percentages of carriers as follows: 41.0% in Arouquesa, 69.9% in Barrosa, 39.4% in Maronesa, 2.8% in Mirandesa, 8...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000118755
更新日期:2008-01-01 00:00:00
abstract::Merle is a distinct coat color and pattern found in numerous species, including the domestic dog, characterized by patches of diluted eumelanin (black pigment) interspersed among areas of normal pigmentation. In dogs, this variegated pattern is caused by an insertion of a SINE element into the canine PMEL gene. Althou...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000491408
更新日期:2018-08-03 00:00:00
abstract::The ability to prepare single-stranded chromosomal target DNA allows innovative uses of FISH technology for studies of chromosome organization. Standard FISH methodologies require functionally single-stranded DNAs in order to facilitate hybridization between the probe and the complementary chromosomal target sequence....
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000079565
更新日期:2004-01-01 00:00:00
abstract::The most prevalent structural variations in the human genome are copy number variations (CNVs), which appear predominantly in the subtelomeric regions. Variable sizes of 4p/4q CNVs have been associated with several different psychiatric findings and developmental disability (DD). We analyzed 105 patients with congenit...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000448905
更新日期:2016-01-01 00:00:00
abstract::We report the first case of an 18p11.32 deletion, detected by array CGH, associated with a drug-resistant form of atypical absence epilepsy, global developmental delay and no signs of holoprosencephaly (HPE). In particular, this region encompasses 19 genes, and none of these genes have been strictly associated with ep...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000438502
更新日期:2015-01-01 00:00:00
abstract::Chloroplasts and mitochondria are semi-autonomous organelles and have their own genomes (cytoplasmic genomes). Physical radiations (e.g., γ-rays) have been widely used in artificial mutation induction for plant germplasm enhancement and for breeding new cultivars. However, little is known at the genomic level about wh...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000506033
更新日期:2020-01-01 00:00:00
abstract::Unbalanced whole-arm translocations (WATs) of the long arm of chromosome 1, resulting in complete trisomy 1q, are chromosomal abnormalities detectable in both solid tumors and hematologic neoplasms. Among the WATs of 1q to acrocentric chromosomes, a few patients with der(1;15) described as a dicentric chromosome have ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000338437
更新日期:2012-01-01 00:00:00
abstract::RNA interference (RNAi) refers to the selective degradation of mRNA induced by double-stranded RNA (dsRNA), first discovered in Caenorhabditis elegans. Homology-dependent silencing phenomena related to RNAi have been observed in many species from all eukaryotic kingdoms. RNAi and related mechanisms share several conse...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000078215
更新日期:2004-01-01 00:00:00
abstract::ZOO-FISH mapping shows human chromosomes 1, 9 and 10 share regions of homology with pig chromosome 10 (SSC10). A more refined comparative map of SSC10 has been developed to help identify positional candidate genes for QTL on SSC10 from human genome sequence. Genes from relevant chromosomal regions of the public human ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000075736
更新日期:2003-01-01 00:00:00
abstract::Phyllotines are sigmodontine rodents endemic to South America with broad genetic variability, Robertsonian polymorphisms being the most frequent. Moreover, this taxon includes a species with multiple sex chromosomes, which is infrequent in mammals. However, molecular cytogenetic techniques have never been applied to p...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000444602
更新日期:2015-01-01 00:00:00
abstract::Integrase (IN) and reverse transcriptase (RT) play a central role in transposition of retroelements. The mechanism of integration by IN and the steps of the replication process mediated by RT are briefly described here. Recently, active recombinant forms of Ty1 IN and RT have been obtained. This has allowed a more det...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000084960
更新日期:2005-01-01 00:00:00
abstract::Spontaneous meiotic mutations of winter rye Secale cereale L. (2n = 14) were revealed in inbred F2 progenies, which were obtained by self-pollination of F1 hybrids resulting from crosses of individual plants of cultivar Vyatka or weedy rye with plants of self-fertile inbred lines. The mutations cause partial or comple...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000082403
更新日期:2005-01-01 00:00:00
abstract::A physical chromosome mapping of the H1 histone and 5S and 18S ribosomal RNA (rRNA) genes was performed in interspecific hybrids of Pseudoplatystoma corruscans and P. reticulatum. The results showed that 5S rRNA clusters were located in the terminal region of 2 chromosomes. H1 histone and 18S ribosomal genes were co-l...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000345299
更新日期:2013-01-01 00:00:00
abstract::The osprey (Pandion haliaetus) has a diploid number of 74 chromosomes, consisting of a large number of medium-sized macrochromosomes and relatively few microchromosomes; this differs greatly from the typical avian karyotype. Chromosome painting with chicken DNA probes revealed that the karyotype of P. haliaetus differ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000358407
更新日期:2014-01-01 00:00:00
abstract::The discovery of complex structural variations that exist within individual genomes has prompted a need to visualize chromosomes at a higher resolution than previously possible. To address this concern, we established a robust, high-resolution fluorescence in situ hybridization (FISH) method that utilizes probes deriv...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000322717
更新日期:2011-01-01 00:00:00
abstract::Chromatin diminution (CD) is a phenomenon of programmed DNA elimination which takes place in early embryogenesis in some eukaryotes. The mechanism and biological role of CD remain largely unknown. During CD in the freshwater copepod Cyclops kolensis, the genome of cells of the somatic lineage is reorganized and reduce...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000494157
更新日期:2018-01-01 00:00:00
abstract::In animals, supernumerary chromosomes and their evolution have mostly been studied in sexual reproducing species. In the present study, for the first time, the natural distribution and stability of supernumerary microchromosomes were investigated in the unisexual fish species Poecilia formosa. Natural habitats through...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000079286
更新日期:2004-01-01 00:00:00
abstract::Most human cancers are characterized by genomic instability. Changes associated with such may result in altered expression of numerous genes. The sequence information available in the public databases can be used to identify transcripts differentially expressed in cancers. Determining cancer-related genes that are com...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000087513
更新日期:2006-01-01 00:00:00
abstract::A 41-year-old Asian woman with bilateral renal angiomyolipomas (AML) was incidentally identified to have a balanced translocation, 46,XX,t(11;12)(p15.4;q15). She had no other features or family history to suggest a diagnosis of tuberous sclerosis. Her healthy daughter had the same translocation and no renal AML at the...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000479463
更新日期:2017-01-01 00:00:00
abstract::During the last decade not only multicolor fluorescence in situ hybridization (FISH) using whole chromosome paints as probes, but also numerous chromosome banding techniques based on FISH have been developed for the human and for the murine genome. This review focuses on such FISH-banding techniques, which were recent...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000094207
更新日期:2006-01-01 00:00:00
abstract::We previously revealed similarity in gene expression patterns between human brain and testis, based on digital differential display analyses of 760 human Unigenes. In the present work, we reanalyzed the gene expression data in many tissues of human and mouse for a large number of genes almost covering the respective w...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000086378
更新日期:2005-01-01 00:00:00
abstract::In rye each B chromosome (B) represents 5.5% of the diploid A genome. Rye Bs have several nuclear to whole plant effects although they seem to bear no genes except for the ones that lead to their maintenance within a population. In this context, and considering that rye Bs are enriched in repetitive non-coding regions...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000079306
更新日期:2004-01-01 00:00:00
abstract::Scapinin has been found to bind to cytoplasmic actin and is also a putative regulatory subunit of protein phosphatase-1 (PP1). It is found attached to the nuclear matrix-intermediate filament (NM-IF) and is down-regulated by differentiation of tumor cells. We have analyzed the genomic structure and tissue-specific exp...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000094797
更新日期:2006-01-01 00:00:00
abstract::In 1957/58 the British Government conducted a series of nuclear tests in the mid-Pacific codenamed Operation Grapple, which involved several naval vessels from Britain and New Zealand. Two New Zealand frigates with 551 personnel onboard were stationed at various distances between 20 and 150 nautical miles from ground ...
journal_title:Cytogenetic and genome research
pub_type: 历史文章,杂志文章
doi:10.1159/000125832
更新日期:2008-01-01 00:00:00
abstract::Members of the NFAT (nuclear factors of activated T cells) gene family have been investigated in numerous organisms, including man and mouse. All NFATs may be synthesized in several isoforms differing in amino or carboxy termini due to 5' and 3' alternative splicing of the corresponding mRNA. Recently, we mapped the m...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000066604
更新日期:2002-01-01 00:00:00
abstract::We analyzed the DNA amount in X and B chromosomes of 2 XX/X0 grasshopper species (Eyprepocnemis plorans and Locusta migratoria), by means of Feulgen image analysis densitometry (FIAD), using previous estimates in L. migratoria as standard (5.89 pg). We first analyzed spermatids of 0B males and found a bimodal distribu...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000324690
更新日期:2011-01-01 00:00:00
abstract::In this report, we describe three unrelated patients with similar symptoms such as mental retardation, growth delay and multiple phenotypic abnormalities. GTG-banding analysis revealed karyotypes with add(1p) in two cases and an add(1q) in the third. Fluorescence in situ hybridization (FISH) analysis using high resolu...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000086388
更新日期:2005-01-01 00:00:00