Abstract:
:Integrase (IN) and reverse transcriptase (RT) play a central role in transposition of retroelements. The mechanism of integration by IN and the steps of the replication process mediated by RT are briefly described here. Recently, active recombinant forms of Ty1 IN and RT have been obtained. This has allowed a more detailed understanding of their biochemical and structural properties and has made possible combined in vitro and in vivo analyses of their functions. A focus of this review is to discuss some of the results obtained thus far with these two recombinant proteins and to propose future directions.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Wilhelm FX,Wilhelm M,Gabriel Adoi
10.1159/000084960keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
269-87issue
1-4eissn
1424-8581issn
1424-859Xpii
84960journal_volume
110pub_type
杂志文章,评审abstract::Previous genetic mapping identified three linkage groups (M1, M18 and M26) in the turkey corresponding to chicken chromosome 1 (GGA1). This is inconsistent with previously described chromosomal differences between these species. FISH analysis of BAC clones corresponding to microsatellite markers from each of the three...
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