Abstract:
:We have identified LIM-kinase (LIMK1 and LIMK2), the only known catalytic protein among LIM-family molecules. Both LIMK1 and LIMK2 phosphorylate (inactivate) cofilin, an actin depolymerizing factor, and induce actin cytoskeleton reorganization. We as well as others concurrently demonstrated that LIMK activation was regulated by the Rho family of GTPases, and LIMK1 and LIMK2 share the distinct functional portion in Rho GTPases-mediated actin dynamics. Although evidence for their physiological significance is tenuous, several studies have focused on understanding LIMK functions, particularly in meiosis and mitosis. This review addresses recent LIMK findings, with emphasis on spermatogenesis studies, upon which future studies can shed light on the role of the LIMK/actin system in meiosis and mitosis.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Takahashi H,Funakoshi H,Nakamura Tdoi
10.1159/000076815keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
290-8issue
3-4eissn
1424-8581issn
1424-859Xpii
76815journal_volume
103pub_type
杂志文章,评审abstract::In animals, supernumerary chromosomes and their evolution have mostly been studied in sexual reproducing species. In the present study, for the first time, the natural distribution and stability of supernumerary microchromosomes were investigated in the unisexual fish species Poecilia formosa. Natural habitats through...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000079286
更新日期:2004-01-01 00:00:00
abstract::Variations of DNA sequences in the human genome range from large, microscopically visible chromosome anomalies to single nucleotide changes. Submicroscopic genomic copy number variations, i.e. chromosomal imbalances which are undetectable by conventional cytogenetic analysis, play an intriguing clinical role. In this ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000442068
更新日期:2015-01-01 00:00:00
abstract::Immunolabeling using site-specific antibodies against phosphorylated histone H3 at serine 10 or serine 28 revealed in plants an almost similar temporal and spatial pattern of both post-translational modification sites at mitosis and meiosis. During the first meiotic division the entire chromosomes are highly H3 phosph...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000074175
更新日期:2003-01-01 00:00:00
abstract::It is well known that TP53 may mediate apoptosis triggered by anticancer drugs. However, accumulating evidence indicates that TP53 may be inactivated by mutations and/or deletions in about 50% of human cancers and, as such, may lead to pronounced resistance to therapeutic agents. Thus, the development of new approache...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000227831
更新日期:2009-01-01 00:00:00
abstract::Black porgy, Acanthopagrus schlegeli Bleeker, is a marine protandrous hermaphrodite fish. A Dmrt1 cDNA was cloned and characterized and in order to study the process of sex change in this species, mRNA transcripts of Dmrt1 were monitored. Dmrt1 was specifically transcribed in testis and seminal vesicle in 2-year-old b...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000074354
更新日期:2003-01-01 00:00:00
abstract::Most human cancers are characterized by genomic instability. Changes associated with such may result in altered expression of numerous genes. The sequence information available in the public databases can be used to identify transcripts differentially expressed in cancers. Determining cancer-related genes that are com...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000087513
更新日期:2006-01-01 00:00:00
abstract::The chromosomes and banding patterns of Steindachneridion sp., a large catfish (Pimelodidae), endemic to the Iguaçu River, Brazil, were analyzed using conventional (C-, G-banding) and restriction enzyme banding methods. The same diploid number (2n = 56) as in other members of the genus and the family was found but the...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000089888
更新日期:2006-01-01 00:00:00
abstract::X chromosome inactivation and DNA methylation are reviewed, with emphasis on the contributions of Susumu Ohno and the predictions made in my 1975 paper (Riggs, 1975), in which I proposed the "maintenance methylase" model for somatic inheritance of methylation patterns and suggested that DNA methylation would be involv...
journal_title:Cytogenetic and genome research
pub_type: 传,历史文章,杂志文章,评审
doi:10.1159/000071569
更新日期:2002-01-01 00:00:00
abstract::RNA interference (RNAi) refers to the selective degradation of mRNA induced by double-stranded RNA (dsRNA), first discovered in Caenorhabditis elegans. Homology-dependent silencing phenomena related to RNAi have been observed in many species from all eukaryotic kingdoms. RNAi and related mechanisms share several conse...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000078215
更新日期:2004-01-01 00:00:00
abstract::2q33 deletions are considered to constitute a distinct clinical entity (Glass syndrome or 2q33 microdeletion syndrome) with a characteristic phenotype. Most patients have moderate to severe developmental delay, speech delay, a particular behavioural phenotype, feeding problems, growth restriction, a typical facial app...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000452090
更新日期:2016-01-01 00:00:00
abstract::This article presents the first physical mapping carried out in the Senegalese sole (Solea senegalensis), an important marine fish species of Southern Europe. Eight probes were designated to pick up genes of interest in aquaculture (candidate genes) from a bacterial artificial chromosome (BAC) library using a method o...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000355001
更新日期:2013-01-01 00:00:00
abstract::It is widely accepted that unrepaired or misrepaired DNA double strand breaks (DSBs) lead to the formation of chromosome aberrations. DSBs induced in the DNA of higher eukaryotes by endogenous processes or exogenous agents can in principle be repaired either by non-homologous endjoining (NHEJ), or homology directed re...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000077461
更新日期:2004-01-01 00:00:00
abstract::Cytogenetic investigations performed in eight Portuguese cattle breeds revealed the presence of rob(1;29) in both heterozygous and homozygous conditions in all, and five breeds, respectively, with variable percentages of carriers as follows: 41.0% in Arouquesa, 69.9% in Barrosa, 39.4% in Maronesa, 2.8% in Mirandesa, 8...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000118755
更新日期:2008-01-01 00:00:00
abstract::The genus Hypostomus has a broad geographic distribution in Brazilian rivers and comprises armored catfishes with a very complicated taxonomy due to the absence of morphological autapomorphies. The existence of nearly 10 allopatric populations with different karyotypes suggests that Hypostomusancistroides represents a...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000492959
更新日期:2018-09-28 00:00:00
abstract::We analyzed the DNA amount in X and B chromosomes of 2 XX/X0 grasshopper species (Eyprepocnemis plorans and Locusta migratoria), by means of Feulgen image analysis densitometry (FIAD), using previous estimates in L. migratoria as standard (5.89 pg). We first analyzed spermatids of 0B males and found a bimodal distribu...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000324690
更新日期:2011-01-01 00:00:00
abstract::The T2 family of miniature inverted-repeat transposable elements (T2-MITE) is a prevalent MITE family found in both Xenopus(Silurana) tropicalis and X. laevis. Some subfamilies, particularly T2-A1 and T2-C, may have originated prior to the diversification of the 2 Xenopus lineages and currently include active members ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000430764
更新日期:2015-01-01 00:00:00
abstract::DNA methylation has been implicated in mammalian development. Transcription units contain CpG islands, but expression of CpG island associated genes in normal tissues was not believed to be controlled by DNA methylation. There are, however, numerous CpG islands containing tissue-dependent and differentially methylated...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000078205
更新日期:2004-01-01 00:00:00
abstract::Neuroglobin and cytoglobin are two novel members of the vertebrate globin family. Their physiological role is poorly understood, although both proteins bind oxygen reversibly and may be involved in cellular oxygen homeostasis. Here we investigate the selective constraints on coding and non-coding sequences of the neur...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000078011
更新日期:2004-01-01 00:00:00
abstract::Transposable elements are disproportionately abundant in the heterochromatin of Drosophila melanogaster. Among the forces contributing to this bias in genomic distribution, fixation due to positive selection has been put forward. We have studied I-related elements which are located in pericentromeric heterochromatin a...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000084950
更新日期:2005-01-01 00:00:00
abstract::Pesticides are some of the most frequently released toxic chemicals into the environment. Exposure to them has been associated with reproductive dysfunction, but the knowledge of the genotoxic risks of these substances is still limited. In vitro and in vivo, many pesticides are shown to induce aneuploidy. Analysis of ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000086915
更新日期:2005-01-01 00:00:00
abstract::New data are presented on the sex chromosomes of the fish species Eigenmannia virescens (Gymnotiformes, Sternopygidae). A new finding, involving the occurrence of ZZ/ZW sex chromosomes, is described in specimens sampled from the São Francisco and Amazon river basins in Brazil. All individuals had a chromosome number o...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000071589
更新日期:2002-01-01 00:00:00
abstract::We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abo...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000336201
更新日期:2012-01-01 00:00:00
abstract::The human male specific expressed gene families CDY and DAZ are known to be repetitively clustered in the Y-specific region of the human Y chromosome. Comparative FISH-mapping of DNA clones specific for CDY and DAZ resulted in a Y-specific but diverse signal pattern within the non-recombining region of the Y-chromosom...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000063021
更新日期:2002-01-01 00:00:00
abstract::Sources of environmental exposures to potentially aneugenic agents are many and include occupational and therapeutic exposures, and exposures associated with lifestyle habits. In this present study, some of these agents and exposure scenarios are discussed that involve potentially large population targets and/or seem ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000323284
更新日期:2011-01-01 00:00:00
abstract::Three activities hallmark meiotic cell division: homologous chromosome pairing, synapsis, and recombination. Recombination and synapsis are well-studied but homologous pairing still holds many black boxes. In the past several years, many studies in plants have yielded insights into the mechanisms of chromosome pairing...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000121080
更新日期:2008-01-01 00:00:00
abstract::Studies of complete genomes are leading to a new understanding of the biology of mammals and providing ongoing insights into the fundamental aspects of the organization and evolution of biological systems. Comparison of primate genomes can identify aspects of their organization, regulation and function that appeared d...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000080796
更新日期:2005-01-01 00:00:00
abstract::Uniparental chromosome elimination occurs in several interspecific hybrids of plants. We studied the mechanism underlying selective elimination of the paternal chromosomes during the development of Hordeum vulgare x H. bulbosum hybrid embryos that is restricted to an early stage of development. In almost all embryos m...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000093334
更新日期:2006-01-01 00:00:00
abstract::The karyotype of the pine woods treefrog, Hyla femoralis, is characterized by primitive XY female/XX male sex chromosomes. The sole difference between the X and the Y is the presence of a nucleolus organizer region (NOR) in the X. Due to a deletion of the NOR in the Y, this chromosome is distinctly smaller than the X....
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000073421
更新日期:2003-01-01 00:00:00
abstract::Apart from a personal tragedy, could Down syndrome, cancer and infertility possibly have something in common? Are there links between a syndrome with physical and mental problems, a tumor growing out of control and the incapability to reproduce? These questions can be answered if we look at the biological functions of...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000323507
更新日期:2011-01-01 00:00:00
abstract::A reduction in recombination in the pseudoautosomal region is associated with an increased frequency of aneuploid 24,XY human sperm. Similarly, individuals with paternally derived Klinefelter syndrome (47,XXY) also have a paucity of recombination in the chromosomes that have undergone nondisjunction. Meiotic studies u...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000086895
更新日期:2005-01-01 00:00:00