Abstract:
:Most human cancers are characterized by genomic instability. Changes associated with such may result in altered expression of numerous genes. The sequence information available in the public databases can be used to identify transcripts differentially expressed in cancers. Determining cancer-related genes that are commonly deregulated in different tumor types may facilitate identification of targets for cancer diagnoses and therapeutic treatments. Using a data-mining tool named Digital Differential Display (DDD) from the UniGene database at the NCBI web site, gene expression levels of ten different tumor types and their counterpart normal tissues were analyzed. Unigenes which showed transcriptional regulation in more than five tumor types with > or =2-fold differences from normal tissues were identified. The expression data of selected Unigenes were subjected to clustering analysis. 127 commonly up-regulated genes and 92 commonly down-regulated genes were identified. Clustering analysis using these genes showed that most tumor types can be clustered into a separate branch from most normal tissues. Nineteen genes that have been shown to be involved in carcinogenesis by experimental evidence were also identified. Present computational analyses revealed 219 candidate cancer-related genes that are commonly deregulated in ten human tumor types which may contribute to the progress of carcinogenesis.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Chen S,Zhu B,Yu Ldoi
10.1159/000087513keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
53-9issue
1-2eissn
1424-8581issn
1424-859Xpii
87513journal_volume
112pub_type
杂志文章abstract::The article reviews the existing methods of multicolor FISH on nuclear targets, first of all, interphase chromosomes. FISH proper and image acquisition are considered as two related components of a single process. We discuss (1) M-FISH (combinatorial labeling + deconvolution + wide-field microscopy); (2) multicolor la...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000094227
更新日期:2006-01-01 00:00:00
abstract::The Ph1 locus in hexaploid wheat (Triticum aestivum L.) enforces diploid-like behavior in the first metaphase of meiosis. To test the hypothesis that this chromosome pairing control is exercised by affecting the degree of chromatin condensation, the dispersion of rye chromatin in interphase nuclei in somatic tissues o...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000112072
更新日期:2007-01-01 00:00:00
abstract::Genome projects allow us to sample copies of a retrotransposon sequence family residing in a host genome. The variation in DNA sequence between these individual copies will reflect the evolutionary process that has spread the sequences through the genome. Here I review quantitatively the expected diversity of elements...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000084970
更新日期:2005-01-01 00:00:00
abstract::Chromosomal locations and amounts of 5-methylcytosine-rich chromosome regions were detected in the karyotypes of 13 bird species by indirect immunofluorescence using a monoclonal anti-5-methylcytosine antibody. These species belong to 7 orders and 10 families of modern (Neognathae) and primitive (Palaeognathae) birds ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000464268
更新日期:2017-01-01 00:00:00
abstract::Telomeres are the nucleoprotein structures that cap the ends of linear chromosomes. The length of telomeric DNA is an important determinant of function; with short telomeres triggering either replicative senescence or, in the absence of a functional DNA damage response, telomere fusion. Telomere fusion can trigger cyc...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000167817
更新日期:2008-01-01 00:00:00
abstract::In recent years increasing attention has been paid to the cytogenetic control of Italian Mediterranean river buffalo (BBU) bulls authorized as sires which are registered in the stud book. Chromosome abnormalities described in this species are mainly numerical and affecting sex chromosomes. During routine cytogenetic a...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000342360
更新日期:2013-01-01 00:00:00
abstract::The relationship between the apparently random chromosomal changes found in aneuploidy and the genetic instability driving the progression of cancer is not clear. We report a test of the hypothesis that aneuploid chromosomal abnormalities might be selected to preserve cell-survival genes during loss of heterozygosity ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000100406
更新日期:2007-01-01 00:00:00
abstract::Hordeum chilense Roem. et Schult. has a number of characteristics interesting for breeding: high crossability with other Triticeae, resistance to biotic and abiotic stresses and high variability for quality traits such as endosperm storage proteins or carotenoid content. xTritordeum, the amphiploids between H. chilens...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000082423
更新日期:2005-01-01 00:00:00
abstract::Recent studies of the LTR-retrotransposons of Schizosaccharomyces pombe have shed considerable light on their evolution and function. The sequencing of the S. pombe genome allowed analysis of its transposon content. This analysis provides information about the maintenance and loss of transposons in the genome. The res...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000084990
更新日期:2005-01-01 00:00:00
abstract::The common fragile sites (CFSs) are large regions of profound genomic instability found in all individuals. A number of the CFSs have been found to span genes that extend over large genomic regions (>700 kb). The expression of these genes is frequently abrogated in a number of different cancers and several of them hav...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000138886
更新日期:2008-01-01 00:00:00
abstract::Using FISH and RH mapping a chromosomal map of rat chromosome 10 (RNO10) was constructed. Our mapping data were complemented by other published data and the final map was compared to maps of mouse and human chromosomes. RNO10 contained segments homologous to mouse chromosomes (MMU) 11, 16 and 17, with evolutionary bre...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000063052
更新日期:2002-01-01 00:00:00
abstract::Fusions of the Runt-related transcription factor 1 (RUNX1) with different partner genes have been associated with various hematological disorders. Interestingly, the C-terminally truncated form of RUNX1 and RUNX1 fusion proteins are similarly considered important contributors to leukemogenesis. Here, we describe a 59-...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000508012
更新日期:2020-01-01 00:00:00
abstract::Economically important traits such as growth and backfat in pigs have been shown to be influenced by genes in swine chromosome (SSC) 10q12-->qter corresponding to human chromosome (HSA) 10p. However, since gene information in the swine chromosomal region was limited, we attempted to generate a dense comparative map be...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000087523
更新日期:2006-01-01 00:00:00
abstract::Reciprocal translocations pose a serious problem in pig breeding due to the reduced fertility of the carriers. This paper presents a new reciprocal translocation in a phenotypically normal, but hypoprolific (20% reduction) boar. Chromosome banding as well as the FISH technique with the use of BAC and telomeric probes ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000355213
更新日期:2014-01-01 00:00:00
abstract::All dogroses (Rosa sect. Caninae) are characterized by the peculiar canina meiosis in which genetic material is unevenly distributed between female and male gametes. The pan-canina rDNA family (termed beta) appears to be conserved in all dogroses analyzed so far. Here, we have studied rDNAs in experimental hybrids obt...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000360437
更新日期:2014-01-01 00:00:00
abstract::Turtle karyotypes are highly conserved compared to other vertebrates; yet, variation in diploid number (2n = 26-68) reflects profound genomic reorganization, which correlates with evolutionary turnovers in sex determination. We evaluate the published literature and newly collected comparative cytogenetic data (G- and ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000447478
更新日期:2016-01-01 00:00:00
abstract::In Europe, 2 different diploid chromosome numbers, 2n = 54 and 2n = 56, have been described in the lesser horseshoe bat (Rhinolophushipposideros). The eastern form with 2n = 56 extends from the Czech Republic to Greece. To date, specimens with 54 chromosomes have been reported only from Spain and Germany. This study e...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000447111
更新日期:2016-01-01 00:00:00
abstract::Rubus yellow net virus (RYNV) infects Rubus spp., causing a severe decline when present in mixed infections with other viruses. RYNV belongs to the family Caulimoviridae, also known as plant pararetroviruses, which can exist as episomal or integrated elements (endogenous). Most of integrated pararetroviruses are nonin...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000509845
更新日期:2020-01-01 00:00:00
abstract::The etiology of primary cutaneous T-cell lymphomas (CTCL) has been poorly understood. CTCL patients show a large variety of non-clonal and clonal chromosome aberrations, but no specific aberration has been found until recently. This review describes cytogenetic and molecular cytogenetic findings and their relevance to...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000108320
更新日期:2007-01-01 00:00:00
abstract::Transposable elements (TE) constitute one of the most variable genomic features among vertebrates, impacting genome size, structure, and composition. Despite their important role in shaping genomic diversity, they have mostly been studied in mammals, which display one of the least diverse genomes in terms of TE divers...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000496416
更新日期:2019-01-01 00:00:00
abstract::Both cattle (Bos taurus) and sheep (Ovis aries) belong to the Bovidae family but to different subfamilies, Bovinae and Caprinae, respectively. From a chromosomal point of view, apart from the already known centric fusions (that occurred during the evolutionary process in the Bovidae family) and the small differences i...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000507645
更新日期:2020-01-01 00:00:00
abstract::The karyotype of the pine woods treefrog, Hyla femoralis, is characterized by primitive XY female/XX male sex chromosomes. The sole difference between the X and the Y is the presence of a nucleolus organizer region (NOR) in the X. Due to a deletion of the NOR in the Y, this chromosome is distinctly smaller than the X....
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000073421
更新日期:2003-01-01 00:00:00
abstract::DNA methylation has been implicated in mammalian development. Transcription units contain CpG islands, but expression of CpG island associated genes in normal tissues was not believed to be controlled by DNA methylation. There are, however, numerous CpG islands containing tissue-dependent and differentially methylated...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000078205
更新日期:2004-01-01 00:00:00
abstract::Early, rapid and reliable diagnosis is of first priority in prenatal medicine. The combination of specific sonographic markers (e.g. nuchal translucency) and biochemical parameters in maternal serum (e.g. free beta-human chorionic gonadotropin, pregnancy-associated plasma protein A), has already dramatically improved ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000094217
更新日期:2006-01-01 00:00:00
abstract::Chromosomal mutagen sensitivity is a common feature of cells from patients with different kinds of cancer. A portion of breast cancer patients also shows an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation or chemical mutagens. Segregation analysis in families of patien...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000077511
更新日期:2004-01-01 00:00:00
abstract::2q37.3 deletion syndrome belongs to the chromosomal 2q37 deletion spectrum which clinically resembles Albright hereditary osteodystrophy (AHO) syndrome. It is is mainly characterized by short stature, obesity, round face, brachydactyly type E, intellectual disability, behavioral problems, and variable intellectual def...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000431389
更新日期:2015-01-01 00:00:00
abstract::We have made a set of chromosome-specific painting probes for the American mink by degenerate oligonucleotide primed-PCR (DOP-PCR) amplification of flow-sorted chromosomes. The painting probes were used to delimit homologous chromosomal segments among human, red fox, dog, cat and eight species of the family Mustelidae...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000063032
更新日期:2002-01-01 00:00:00
abstract::A comparative cytogenetic analysis was carried out on four Hylinae tree frogs from Brazil ((Aparasphenodon brunoi, Corythomantis greeningi, Osteocephalus langsdorffii, and Scinax fuscovarius) using Giemsa staining, BrdU replication banding, Ag-NOR staining, C-banding, DAPI and CMA(3) fluorochrome staining, and fluores...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000076304
更新日期:2003-01-01 00:00:00
abstract::The ChickRH6 radiation hybrid panel has been used to construct consensus chromosome radiation hybrid (RH) maps of the chicken genome. Markers genotyped were either from throughout the genome or targeted to specific chromosomes and a large proportion (one third) of data was the result of collaborative efforts. Altogeth...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000103160
更新日期:2007-01-01 00:00:00
abstract::Only mammals have relinquished parthenogenesis as a means of producing descendants. Bi-parental reproduction is necessary due to parent-specific epigenetic modification of the genome during gametogenesis, which leads to non-equivalent expression of imprinted genes from the maternal and paternal alleles. However, a ser...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000090812
更新日期:2006-01-01 00:00:00