Abstract:
:High density livestock to human comparative maps are necessary for the implementation of comparative positional candidate gene cloning. We have constructed a high-density comparative radiation hybrid (RH) map of the telomeric end of bovine chromosome 2 (BTA2) using a 12,000-rad whole genome cattle-hamster radiation hybrid (WGRH) panel. Eighteen bovine EST markers with orthologues on human chromosomes 1 and 2 (HSA1 and HSA2), together with nine microsatellite markers, were typed against the 180 cell lines of the WGRH panel. Twenty-one markers were included in the multi-point framework map at LOD =3.0. The comparative analysis reveals a new segment of highly conserved synteny between HSA2 and BTA2.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Liu Z,Womack JE,Antoniou Edoi
10.1159/000076295keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
89-93issue
1-2eissn
1424-8581issn
1424-859Xpii
76295journal_volume
103pub_type
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