Abstract:
:The non-random positioning of chromosome territories (CTs) in lymphocyte cell nuclei has raised the question whether systematic chromosome-chromosome associations exist which have significant influence on interchange rates. In such a case the spatial proximity of certain CTs or even of clusters of CTs is expected to increase the respective exchange yields significantly, in comparison to a random association of CTs. In the present study we applied computer simulated arrangements of CTs to calculate interchange frequencies between all heterologous CT pairs, assuming a uniform action of the molecular repair machinery. For the positioning of CTs in the virtual nuclear volume we assumed a) a statistical, and b) a gene density-correlated arrangement. The gene density-correlated arrangement regards the more experimentally observed interior localization of gene-rich and the more peripheral positioning of gene-poor CTs. Regarding one-chromosome yields, remarkable differences for single CTs were observed taking into account the gene density-correlated distribution of CTs.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Kreth G,Finsterle J,Cremer Cdoi
10.1159/000077481keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
157-61issue
1-4eissn
1424-8581issn
1424-859Xpii
77481journal_volume
104pub_type
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