Abstract:
:For normal transition through meiosis, chromosomes rely on pairing with their homologues. Chromosomes which fail to pair, univalents, behave irregularly and may undergo various types of breakage across their centromeres. Here, we analyzed the meiotic behavior of misdivision products themselves: isochromosomes and telocentrics in wheat. Both types of chromosomes behaved in the same fashion as standard 2-armed chromosomes. The 2 most frequent scenarios were separation of sister chromatids in anaphase I or monopolar/bipolar attachment of the univalent to the spindle apparatus with unseparated chromatids. Misdivision was rare, and its frequency appeared directly related to the size of the centromere. The previously deduced relationship between misdivision frequency and chromosome size was likely erroneous and can be explained by a general relationship between chromosome length and the size of its centromere. Pairing of identical arms in isochromosomes did not protect them from misdivision. It is not chiasmate pairing that protects from misdivision but mechanistic issues that arise through that pairing.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Kopecky D,Lukaszewski AJdoi
10.1159/000497301subject
Has Abstractpub_date
2019-01-01 00:00:00pages
179-188issue
3eissn
1424-8581issn
1424-859Xpii
000497301journal_volume
157pub_type
杂志文章abstract::2q37.3 deletion syndrome belongs to the chromosomal 2q37 deletion spectrum which clinically resembles Albright hereditary osteodystrophy (AHO) syndrome. It is is mainly characterized by short stature, obesity, round face, brachydactyly type E, intellectual disability, behavioral problems, and variable intellectual def...
journal_title:Cytogenetic and genome research
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abstract::In this report, we describe three unrelated patients with similar symptoms such as mental retardation, growth delay and multiple phenotypic abnormalities. GTG-banding analysis revealed karyotypes with add(1p) in two cases and an add(1q) in the third. Fluorescence in situ hybridization (FISH) analysis using high resolu...
journal_title:Cytogenetic and genome research
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abstract::Spinocerebellar ataxia type 12 (SCA12), now described in European-American and Asian (Indian) pedigrees, is unique among the SCAs from clinical, pathological, and molecular perspectives. Clinically, the distinguishing feature is early and prominent action tremor with variability in other signs. Pathologically, brain M...
journal_title:Cytogenetic and genome research
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journal_title:Cytogenetic and genome research
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abstract::Genets (Genetta) are a genus of African mammalian carnivorans with 14 currently recognized species, although taxonomic uncertainties remain, particularly regarding the number of species within the large-spotted genet complex. This study presents the first banded karyotype and molecular cytogenetic analysis of a geneti...
journal_title:Cytogenetic and genome research
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doi:10.1159/000450627
更新日期:2016-01-01 00:00:00
abstract::To define the process of karyotypic evolution in the Galliformes on a molecular basis, we conducted genome-wide comparative chromosome painting for eight species, i.e. silver pheasant (Lophura nycthemera), Lady Amherst's pheasant (Chrysolophus amherstiae), ring-necked pheasant (Phasianus colchicus), turkey (Meleagris ...
journal_title:Cytogenetic and genome research
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doi:10.1159/000078570
更新日期:2004-01-01 00:00:00
abstract::Birds have a ubiquitous, female heterogametic, ZW sex chromosome system. The current model suggests that the Z chromosome and its degraded partner, the W chromosome, evolved from an ancestral pair of autosomes independently from the mammalian XY male heteromorphic sex chromosomes--which are similar in size, but not ge...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::The Mx gene was originally found in laboratory mice in an infection experiment using influenza virus (Lindermann, 1962). Almost all of the mouse strains in that experiment died from the infection, and only the A2G strain had resistance to the virus. This resistant character was shown to be inherited as a single autoso...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000103200
更新日期:2007-01-01 00:00:00
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journal_title:Cytogenetic and genome research
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更新日期:2017-01-01 00:00:00
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journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000106441
更新日期:2007-01-01 00:00:00
abstract::The genus Hypostomus has a broad geographic distribution in Brazilian rivers and comprises armored catfishes with a very complicated taxonomy due to the absence of morphological autapomorphies. The existence of nearly 10 allopatric populations with different karyotypes suggests that Hypostomusancistroides represents a...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000492959
更新日期:2018-09-28 00:00:00
abstract::ATM, the protein product of the gene mutated in the human autosomal recessive disorder ataxia telangiectasia, is involved in detection of double strand breaks (DSBs) and is a key component of the damage surveillance network of cell cycle proteins. In somatic cells ATM phosphorylates many other proteins including p53, ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000080603
更新日期:2004-01-01 00:00:00
abstract::2q33 deletions are considered to constitute a distinct clinical entity (Glass syndrome or 2q33 microdeletion syndrome) with a characteristic phenotype. Most patients have moderate to severe developmental delay, speech delay, a particular behavioural phenotype, feeding problems, growth restriction, a typical facial app...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000452090
更新日期:2016-01-01 00:00:00
abstract::The catarrhine primates were the first group of species studied with comparative molecular cytogenetics. Many of the fundamental techniques and principles of analysis were initially applied to comparisons in these primates, including interspecific chromosome painting, reciprocal chromosome painting and the extensive u...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000339381
更新日期:2012-01-01 00:00:00
abstract::This article presents the first physical mapping carried out in the Senegalese sole (Solea senegalensis), an important marine fish species of Southern Europe. Eight probes were designated to pick up genes of interest in aquaculture (candidate genes) from a bacterial artificial chromosome (BAC) library using a method o...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000355001
更新日期:2013-01-01 00:00:00
abstract::In order to determine synteny conservation of the avian Z chromosome, a chicken (Gallus gallus, GGA) Z chromosome painting probe was hybridized to the chromosomes of 14 bird species belonging to 11 different families. The GGAZ painted the Z chromosomes in all species analyzed, suggesting strong conservation of its gen...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000163092
更新日期:2008-01-01 00:00:00
abstract::The mitotic chromosomes of 4 anuran species were examined by various classical banding techniques and by fluorescence in situ hybridization using a (TTAGGG)n repeat. Large intrachromosomal telomeric sequences (ITSs) were demonstrated in differing numbers and chromosome locations. A detailed comparison of the present r...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000446298
更新日期:2016-01-01 00:00:00
abstract::Mutations/deletions of the IMMP2L gene have been associated with different cognitive/behavioral disturbances, including autism spectrum disorders (ASD). The penetrance of these defects is not complete since they often are inherited from a healthy parent. Using array-CGH in a cohort of 37 ASD patients, we found 2 subje...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000489001
更新日期:2018-01-01 00:00:00
abstract::Scapinin has been found to bind to cytoplasmic actin and is also a putative regulatory subunit of protein phosphatase-1 (PP1). It is found attached to the nuclear matrix-intermediate filament (NM-IF) and is down-regulated by differentiation of tumor cells. We have analyzed the genomic structure and tissue-specific exp...
journal_title:Cytogenetic and genome research
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doi:10.1159/000094797
更新日期:2006-01-01 00:00:00
abstract::Both cattle (Bos taurus) and sheep (Ovis aries) belong to the Bovidae family but to different subfamilies, Bovinae and Caprinae, respectively. From a chromosomal point of view, apart from the already known centric fusions (that occurred during the evolutionary process in the Bovidae family) and the small differences i...
journal_title:Cytogenetic and genome research
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更新日期:2020-01-01 00:00:00
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journal_title:Cytogenetic and genome research
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journal_title:Cytogenetic and genome research
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journal_title:Cytogenetic and genome research
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更新日期:2015-01-01 00:00:00
abstract::We have made a set of chromosome-specific painting probes for the American mink by degenerate oligonucleotide primed-PCR (DOP-PCR) amplification of flow-sorted chromosomes. The painting probes were used to delimit homologous chromosomal segments among human, red fox, dog, cat and eight species of the family Mustelidae...
journal_title:Cytogenetic and genome research
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doi:10.1159/000063032
更新日期:2002-01-01 00:00:00
abstract::In an attempt to analyze the organization of repetitive DNAs in the amphibian genome, 7 microsatellite motifs and a 5S rDNA sequence were synthesized and mapped in the karyotypes of 5 Amolops species. The results revealed nonrandom distribution of the microsatellite repeats, usually in the heterochromatic regions, as ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000499416
更新日期:2019-01-01 00:00:00
abstract::Chloroplasts and mitochondria are semi-autonomous organelles and have their own genomes (cytoplasmic genomes). Physical radiations (e.g., γ-rays) have been widely used in artificial mutation induction for plant germplasm enhancement and for breeding new cultivars. However, little is known at the genomic level about wh...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Cytogenetic and genome research
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract::Retroelements (REs) actively reshape genomes through genomic rearrangements, creation of new genes and modulation of the regulatory machinery of existing genes, thus introducing genomic novelties which potentially may be subject to natural selection. Thousands of RE integrations, presumably distinguishing the human an...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::Black porgy, Acanthopagrus schlegeli Bleeker, is a marine protandrous hermaphrodite fish. A Dmrt1 cDNA was cloned and characterized and in order to study the process of sex change in this species, mRNA transcripts of Dmrt1 were monitored. Dmrt1 was specifically transcribed in testis and seminal vesicle in 2-year-old b...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000074354
更新日期:2003-01-01 00:00:00
abstract::Acrylamide (AA) is an important industrial chemical used mainly in the production of polymers. It can be absorbed through the skin. AA was shown to be a germ cell clastogen that entails a genetic risk for exposed workers. The genetic risk calculation was based on mouse heritable translocation test data obtained after ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00