Abstract:
:ATM, the protein product of the gene mutated in the human autosomal recessive disorder ataxia telangiectasia, is involved in detection of double strand breaks (DSBs) and is a key component of the damage surveillance network of cell cycle proteins. In somatic cells ATM phosphorylates many other proteins including p53, an important regulator of cell cycle control. Mice deficient for Atm are male sterile with arrest and apoptosis occurring at testis epithelial stage IV, which in normal spermatocytes corresponds to mid-pachynema. Unlike the situation in somatic cells, we find no evidence that disruption of the Trp53 (p53) gene, or its down-stream target Cdkn1a (p21/Cip1) results in even a partial rescue of the Atm defect.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Ashley T,Westphal C,Plug-de Maggio A,de Rooij DGdoi
10.1159/000080603keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
256-62issue
3-4eissn
1424-8581issn
1424-859Xpii
80603journal_volume
107pub_type
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