Chromosome Banding in Amphibia. XXXIII. Demonstration of 5-Methylcytosine-Rich Heterochromatin in Anura.

abstract：:We analyzed genetic changes in condylomas (four cases), vulvar intraepithelial neoplasia I-III (VIN I-III, eleven cases), and primary vulvar squamous cell carcinomas (VSCC, ten cases) by high-resolution comparative genomic hybridization (HR-CGH) and flowcytometry. All samples were also human papilloma virus (HPV)-geno...

journal_title：Cytogenetic and genome research

authors： Bryndorf T,Kirchhoff M,Larsen J,Andreasson B,Bjerregaard B,Westh H,Rose H,Lundsteen C

更新日期：2004-01-01 00:00:00

abstract：:The identification of individual dog chromosomes is problematic because the 38 pairs of autosomes are small and acrocentric. Here we describe the design and application of a FISH tool that enables definitive identification of each dog autosome in a normal karyotype, without relying on subjective interpretation of DAPI...

journal_title：Cytogenetic and genome research

authors： Courtay-Cahen C,Griffiths LA,Hudson R,Starkey M

更新日期：2007-01-01 00:00:00

abstract：:Gross chromosomal rearrangements and aneuploidy are among the most common somatic genomic abnormalities that occur during cancer initiation and progression, in particular in human solid tumor carcinogenesis. The loss of large chromosomal regions as consequence of gross rearrangements (e.g. deletions, monosomies, unbal...

journal_title：Cytogenetic and genome research

authors： Ludes-Meyers JH,Bednarek AK,Popescu NC,Bedford M,Aldaz CM

更新日期：2003-01-01 00:00:00

abstract：:Fanconi anemia (FA) cells are generally hypersensitive to DNA cross-linking agents, implying that mutations in the different FANC genes cause a similar DNA repair defect(s). By using a customized cDNA microarray chip for DNA repair- and cell cycle-associated genes, we identified three genes, cathepsin B (CTSB), glutar...

journal_title：Cytogenetic and genome research

authors： Galetzka D,Weis E,Rittner G,Schindler D,Haaf T

更新日期：2008-01-01 00:00:00

abstract：:Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e., oropharyngeal squamous cell carcinomas (OPSCC). The mod...

journal_title：Cytogenetic and genome research

authors： Gao G,Smith DI

更新日期：2016-01-01 00:00:00

abstract：:We have investigated the karyotype relationships of two oriental voles, i.e. the Yulong vole (Eothenomys proditor, 2n = 32) and the large oriental vole (Eothenomys miletus, 2n = 56) as well as the Clarke's vole (Microtus clarkei, 2n = 52), by a combined approach of cross-species chromosome painting and high-resolution...

journal_title：Cytogenetic and genome research

authors： Li T,Wang J,Su W,Yang F

更新日期：2006-01-01 00:00:00

abstract：:Early, rapid and reliable diagnosis is of first priority in prenatal medicine. The combination of specific sonographic markers (e.g. nuchal translucency) and biochemical parameters in maternal serum (e.g. free beta-human chorionic gonadotropin, pregnancy-associated plasma protein A), has already dramatically improved ...

journal_title：Cytogenetic and genome research

authors： Stumm M,Wegner RD,Bloechle M,Eckel H

更新日期：2006-01-01 00:00:00

abstract：:Pesticides are some of the most frequently released toxic chemicals into the environment. Exposure to them has been associated with reproductive dysfunction, but the knowledge of the genotoxic risks of these substances is still limited. In vitro and in vivo, many pesticides are shown to induce aneuploidy. Analysis of ...

journal_title：Cytogenetic and genome research

authors： Härkönen K

更新日期：2005-01-01 00:00:00

abstract：:In addition to their location at terminal positions, telomeric-like repeats are also present at internal sites of the chromosomes (intrachromosomal or interstitial telomeric sequences, ITSs). According to their sequence organization and genomic location, two different kinds of ITSs can be identified: (1) heterochromat...

journal_title：Cytogenetic and genome research

authors： Ruiz-Herrera A,Nergadze SG,Santagostino M,Giulotto E

更新日期：2008-01-01 00:00:00

abstract：:Chromosome homologies in reptiles have been investigated extensively by gene mapping and chromosome painting. Relative chromosome size can be estimated roughly from conventional karyotypes, but chromosome GC content cannot be evaluated by any of these approaches. However, GC content can be obtained by whole-genome seq...

journal_title：Cytogenetic and genome research

authors： Kasai F,O'Brien PCM,Ferguson-Smith MA

更新日期：2019-01-01 00:00:00

abstract：:Acrylamide (AA) is an important industrial chemical used mainly in the production of polymers. It can be absorbed through the skin. AA was shown to be a germ cell clastogen that entails a genetic risk for exposed workers. The genetic risk calculation was based on mouse heritable translocation test data obtained after ...

journal_title：Cytogenetic and genome research

authors： Adler ID,Gonda H,Hrabé de Angelis M,Jentsch I,Otten IS,Speicher MR

更新日期：2004-01-01 00:00:00

abstract：:Breast cancer is a complex and heterogeneous disease, and the establishment of cell models in order to properly study the disease at the molecular and cellular level is of utmost importance. Here, we present the cytogenetic characterization and gene expression analysis of the tumoral mammary rat cell line CLS-ACI-1. T...

journal_title：Cytogenetic and genome research

authors： Meles S,Adega F,Castro J,Chaves R

更新日期：2015-01-01 00:00:00

abstract：:Members of the NFAT (nuclear factors of activated T cells) gene family have been investigated in numerous organisms, including man and mouse. All NFATs may be synthesized in several isoforms differing in amino or carboxy termini due to 5' and 3' alternative splicing of the corresponding mRNA. Recently, we mapped the m...

journal_title：Cytogenetic and genome research

authors： Dalski A,Hebinck A,Winking H,Butzmann U,Schwinger E,Zühlke Ch

更新日期：2002-01-01 00:00:00

abstract：:The T2 family of miniature inverted-repeat transposable elements (T2-MITE) is a prevalent MITE family found in both Xenopus(Silurana) tropicalis and X. laevis. Some subfamilies, particularly T2-A1 and T2-C, may have originated prior to the diversification of the 2 Xenopus lineages and currently include active members ...

journal_title：Cytogenetic and genome research

authors： Hikosaka A,Uno Y,Matsuda Y

更新日期：2015-01-01 00:00:00

abstract：:The mouse UGRP gene family consists of two genes, Ugrp1 and Ugrp2. In this study, the genomic structure and expression patterns of Ugrp2 and its alternative spliced form were characterized. The authentic Ugrp2 gene has three exons and two introns, similar to the Ugrp1 gene, which produces a secreted protein. The Ugrp2...

journal_title：Cytogenetic and genome research

authors： Niimi T,Copeland NG,Gilbert DJ,Jenkins NA,Srisodsai A,Zimonjic DB,Keck-Waggoner CL,Popescu NC,Kimura S

更新日期：2002-01-01 00:00:00

abstract：:Plant meiosis studies have enjoyed a fantastic boom in recent years with the use of Arabidopsis thaliana as a model not only for molecular genetics and genomics but also for cytogenetics. In this article we describe a new protocol for immunolabelling meiotic proteins that allows the detection of a large range of prote...

journal_title：Cytogenetic and genome research

authors： Chelysheva L,Grandont L,Vrielynck N,le Guin S,Mercier R,Grelon M

更新日期：2010-07-01 00:00:00

abstract：:Correct imprinting is crucial for normal fetal and placental development in mammals. Experimental evidence in animal models and epidemiological studies in humans suggest that assisted reproductive technologies (ARTs) can interfere with imprinted gene regulation in gametogenesis and early embryogenesis. Bos taurus is a...

journal_title：Cytogenetic and genome research

authors： Hansmann T,Heinzmann J,Wrenzycki C,Zechner U,Niemann H,Haaf T

更新日期：2011-01-01 00:00:00

abstract：:The Congo African grey parrot (Psittacus erithacus, PER) is an endemic species of Central Africa, valued for its intelligence and listed as vulnerable due to poaching and habitat destruction. Improved knowledge about the P. erithacus genome is needed to address key biological questions and conservation of this species...

journal_title：Cytogenetic and genome research

authors： Seibold-Torres C,Owens E,Chowdhary R,Ferguson-Smith MA,Tizard I,Raudsepp T

更新日期：2015-01-01 00:00:00

abstract：:Genomic imprinting has a special role in placental biology. Imprinted genes are often strongly expressed in the placenta, and the allelic expression bias due to imprinting is sometimes stronger in this extraembryonic organ than in the embryo and adult. Mutations, epimutations, and uniparental disomies affecting imprin...

journal_title：Cytogenetic and genome research

authors： Tycko B

更新日期：2006-01-01 00:00:00

abstract：:The discovery of complex structural variations that exist within individual genomes has prompted a need to visualize chromosomes at a higher resolution than previously possible. To address this concern, we established a robust, high-resolution fluorescence in situ hybridization (FISH) method that utilizes probes deriv...

journal_title：Cytogenetic and genome research

authors： Yamada NA,Rector LS,Tsang P,Carr E,Scheffer A,Sederberg MC,Aston ME,Ach RA,Tsalenko A,Sampas N,Peter B,Bruhn L,Brothman AR

更新日期：2011-01-01 00:00:00

abstract：:Analysis of the horse genome is proceeding at a rapid pace. Within a short span of 6-7 years, approximately 1,500 markers have been mapped in horse, of which at least half are genes/ESTs. Health, performance and phenotypic characteristic are of major concern/interest to horse breeders and owners. Current efforts to an...

journal_title：Cytogenetic and genome research

authors： Chowdhary BP,Bailey E

更新日期：2003-01-01 00:00:00

abstract：:Loss-of-function mutations of the MECP2 gene are the cause of most cases of Rett syndrome in females, a progressive neurodevelopmental disorder characterized by severe mental retardation, global regression, hand stereotypies, and microcephaly. On the other hand, gain of dosage of this gene causes the MECP2 duplication...

journal_title：Cytogenetic and genome research

authors： Mayo S,Monfort S,Roselló M,Orellana C,Oltra S,Armstrong J,Català V,Martínez F

更新日期：2011-01-01 00:00:00

abstract：:Klinefelter's syndrome (KS) is the most common sex chromosome abnormality identified in human males. This syndrome is generally associated with infertility. Men with KS may have a 47,XXY or a 46,XY/47,XXY karyotype. Studies carried out in humans and mice suggest that only XY cells are able to enter and complete meiosi...

journal_title：Cytogenetic and genome research

authors： Pinton A,Barasc H,Raymond Letron I,Bordedebat M,Mary N,Massip K,Bonnet N,Calgaro A,Dudez AM,Feve K,Riquet J,Yerle M,Ducos A

更新日期：2011-01-01 00:00:00

abstract：:It is widely accepted that unrepaired or misrepaired DNA double strand breaks (DSBs) lead to the formation of chromosome aberrations. DSBs induced in the DNA of higher eukaryotes by endogenous processes or exogenous agents can in principle be repaired either by non-homologous endjoining (NHEJ), or homology directed re...

journal_title：Cytogenetic and genome research

authors： Iliakis G,Wang H,Perrault AR,Boecker W,Rosidi B,Windhofer F,Wu W,Guan J,Terzoudi G,Pantelias G

更新日期：2004-01-01 00:00:00

abstract：:We analyzed the DNA amount in X and B chromosomes of 2 XX/X0 grasshopper species (Eyprepocnemis plorans and Locusta migratoria), by means of Feulgen image analysis densitometry (FIAD), using previous estimates in L. migratoria as standard (5.89 pg). We first analyzed spermatids of 0B males and found a bimodal distribu...

journal_title：Cytogenetic and genome research

authors： Ruiz-Ruano FJ,Ruiz-Estévez M,Rodríguez-Pérez J,López-Pino JL,Cabrero J,Camacho JP

更新日期：2011-01-01 00:00:00

abstract：:We report on the conventional cytogenetic and fluorescence in situ hybridization (FISH) results obtained for a 3.5-year-old girl with developmental and language delay and a supernumerary ring chromosome mosaicism in 8% of T-lymphocytes analyzed. Using different conventional and molecular cytogenetic techniques as YAC ...

journal_title：Cytogenetic and genome research

authors： Tönnies H,Hennies HC,Spohr HL,Neitzel H

更新日期：2003-01-01 00:00:00

abstract：:Precise breakpoint definition of chromosomal rearrangements using conventional banding techniques often fails, especially when more than two breakpoints are involved. The classic banding procedure results in a pattern of alternating light and dark bands. Hence, in banded chromosomes a specific chromosomal band is rath...

journal_title：Cytogenetic and genome research

authors： Chudoba I,Hickmann G,Friedrich T,Jauch A,Kozlowski P,Senger G

更新日期：2004-01-01 00:00:00

abstract：:The suborder Serpentes is divided into 2 infraorders, Scolecophidia and Alethinophidia, which diverged at an early stage of snake diversification. In this study, we examined karyotypes of 4 scolecophidian species (Letheobia simonii, Xerotyphlops vermicularis, Indotyphlops braminus, and Myriopholis macrorhyncha) and pe...

journal_title：Cytogenetic and genome research

authors： Matsubara K,Kumazawa Y,Ota H,Nishida C,Matsuda Y

更新日期：2019-01-01 00:00:00

abstract：:Turtle karyotypes are highly conserved compared to other vertebrates; yet, variation in diploid number (2n = 26-68) reflects profound genomic reorganization, which correlates with evolutionary turnovers in sex determination. We evaluate the published literature and newly collected comparative cytogenetic data (G- and ...

journal_title：Cytogenetic and genome research

authors： Montiel EE,Badenhorst D,Lee LS,Literman R,Trifonov V,Valenzuela N

更新日期：2016-01-01 00:00:00

abstract：:It is well known that TP53 may mediate apoptosis triggered by anticancer drugs. However, accumulating evidence indicates that TP53 may be inactivated by mutations and/or deletions in about 50% of human cancers and, as such, may lead to pronounced resistance to therapeutic agents. Thus, the development of new approache...

journal_title：Cytogenetic and genome research

authors： Wang J,Wang XF,Zhang LG,Xie SY,Li ZL,Li YJ,Li HH,Jiao F

更新日期：2009-01-01 00:00:00