Abstract:
:Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e., oropharyngeal squamous cell carcinomas (OPSCC). The model for how HPV causes cancer is derived from several decades of study on cervical cancer, and it is just presumed that this model is not only completely valid for cervical cancer but for all other HPV-driven cancers as well. Next-generation sequencing (NGS) has now provided the necessary tools to characterize genomic alterations in cancer cells and can precisely determine the physical status of HPV in those cells as well. We discuss recent discoveries from different applications of NGS in both cervical cancer and OPSCCs, including whole-genome sequencing and mate-pair NGS. We also discuss what NGS studies have revealed about the different ways that HPV can be involved in cancer formation, specifically comparing cervical cancer and OPSCC.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Gao G,Smith DIdoi
10.1159/000458166subject
Has Abstractpub_date
2016-01-01 00:00:00pages
185-193issue
3-4eissn
1424-8581issn
1424-859Xpii
000458166journal_volume
150pub_type
杂志文章,评审abstract::The mammalian collagen, type IX, alpha 2 gene (COL9A2) encodes the alpha-2 chain of type IX collagen and is located on horse chromosome 2p16-->p14 harbouring a quantitative trait locus for osteochondrosis. We isolated a bacterial artificial chromosome (BAC) clone containing the equine COL9A2 gene and determined the co...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000095229
更新日期:2006-01-01 00:00:00
abstract::The identification of individual dog chromosomes is problematic because the 38 pairs of autosomes are small and acrocentric. Here we describe the design and application of a FISH tool that enables definitive identification of each dog autosome in a normal karyotype, without relying on subjective interpretation of DAPI...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000098187
更新日期:2007-01-01 00:00:00
abstract::DNA methylation has been implicated in mammalian development. Transcription units contain CpG islands, but expression of CpG island associated genes in normal tissues was not believed to be controlled by DNA methylation. There are, however, numerous CpG islands containing tissue-dependent and differentially methylated...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000078205
更新日期:2004-01-01 00:00:00
abstract::Precise breakpoint definition of chromosomal rearrangements using conventional banding techniques often fails, especially when more than two breakpoints are involved. The classic banding procedure results in a pattern of alternating light and dark bands. Hence, in banded chromosomes a specific chromosomal band is rath...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000077521
更新日期:2004-01-01 00:00:00
abstract::Uniparental chromosome elimination occurs in several interspecific hybrids of plants. We studied the mechanism underlying selective elimination of the paternal chromosomes during the development of Hordeum vulgare x H. bulbosum hybrid embryos that is restricted to an early stage of development. In almost all embryos m...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000093334
更新日期:2006-01-01 00:00:00
abstract::Holoprosencephaly (HPE) is the most common congenital malformation of the brain and face in humans. In this study we report the analysis of SIL (Sumacr;CL iumacr;nterrupting lumacr;ocus) as a candidate gene for HPE. Fluorescent in situ hybridization (FISH) analysis using a BAC 246e16 confirmed the assignment of SIL to...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000064057
更新日期:2002-01-01 00:00:00
abstract::Genome duplication creates redundancy in proteins and their interaction networks, and subsequent smaller-scale gene duplication can further amplify genetic redundancy. Mutations then lead to the loss, maintenance or functional divergence of duplicated genes. Genome duplication occurred many times in African clawed fro...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000431108
更新日期:2015-01-01 00:00:00
abstract::Black porgy, Acanthopagrus schlegeli Bleeker, is a marine protandrous hermaphrodite fish. A Dmrt1 cDNA was cloned and characterized and in order to study the process of sex change in this species, mRNA transcripts of Dmrt1 were monitored. Dmrt1 was specifically transcribed in testis and seminal vesicle in 2-year-old b...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000074354
更新日期:2003-01-01 00:00:00
abstract::Acrylamide (AA) is an important industrial chemical used mainly in the production of polymers. It can be absorbed through the skin. AA was shown to be a germ cell clastogen that entails a genetic risk for exposed workers. The genetic risk calculation was based on mouse heritable translocation test data obtained after ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000077501
更新日期:2004-01-01 00:00:00
abstract::Hordeum chilense Roem. et Schult. has a number of characteristics interesting for breeding: high crossability with other Triticeae, resistance to biotic and abiotic stresses and high variability for quality traits such as endosperm storage proteins or carotenoid content. xTritordeum, the amphiploids between H. chilens...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000082423
更新日期:2005-01-01 00:00:00
abstract::Loss-of-function mutations of the MECP2 gene are the cause of most cases of Rett syndrome in females, a progressive neurodevelopmental disorder characterized by severe mental retardation, global regression, hand stereotypies, and microcephaly. On the other hand, gain of dosage of this gene causes the MECP2 duplication...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000330917
更新日期:2011-01-01 00:00:00
abstract::In recent years increasing attention has been paid to the cytogenetic control of Italian Mediterranean river buffalo (BBU) bulls authorized as sires which are registered in the stud book. Chromosome abnormalities described in this species are mainly numerical and affecting sex chromosomes. During routine cytogenetic a...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000342360
更新日期:2013-01-01 00:00:00
abstract::High density livestock to human comparative maps are necessary for the implementation of comparative positional candidate gene cloning. We have constructed a high-density comparative radiation hybrid (RH) map of the telomeric end of bovine chromosome 2 (BTA2) using a 12,000-rad whole genome cattle-hamster radiation hy...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000076295
更新日期:2003-01-01 00:00:00
abstract::To obtain an estimate of the variation in common fragile sites (CFSs) among individuals, aphidicolin (APC)-induced chromosomal breakage data were analyzed for 20 karyotypically normal adult humans. As it is specifically designed to meet the analytical requirements for considering fragile sites as presence/absence char...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000073411
更新日期:2003-01-01 00:00:00
abstract::Mouse distal chromosome 2 was one of the earliest described imprinting regions. Maternal and paternal inheritance of the region is associated with opposite phenotypes affecting growth, development and behaviour. Mis-expression of proteins determined by the imprinted Gnas locus can account for the phenotypes. The impri...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000090832
更新日期:2006-01-01 00:00:00
abstract::The Deleted in AZoospermia Like (DAZL) gene is a member of the DAZ family and encodes an RNA-binding protein that is expressed in prenatal and postnatal germ cells of males and females. In the human, there are five highly-related members in the DAZ family, four (DAZ1-4) on the Y chromosome and one (DAZL) on an autosom...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000097419
更新日期:2007-01-01 00:00:00
abstract::An experimental approach using monoclonal anti-5-methylcytosine (5-MeC) antibodies and indirect immunofluorescence was elaborated for detecting 5-MeC-rich chromosome regions in anuran chromosomes. This technique was applied to mitotic metaphases of 6 neotropical frog species belonging to 6 genera and 4 families. The h...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000446141
更新日期:2016-01-01 00:00:00
abstract::Here, a new satellite-DNA family is isolated and characterized from wedge sole, Dicologoglossa cuneata Moreau, 1881 (Pleuronectiformes), a fish having a small genome. This satellite-DNA family of sequences was isolated by conventional cloning after digestion of genomic DNA with the DraI restriction enzyme. Repeat unit...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000138896
更新日期:2008-01-01 00:00:00
abstract::Osteosarcomas are primary tumors of bone that most often develop in adolescents. They are characterized by complex genomic changes including amplifications, deletions, and translocations. The chromosome region 17p11.2p12 is frequently amplified in human high grade osteosarcomas (25% of cases), suggesting the presence ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000451046
更新日期:2016-01-01 00:00:00
abstract::Sperm chromosome abnormalities cut across a number of areas relevant to ICC XV. The association between increased levels of sperm aneuploidy (usually disomy) and male infertility has implications for the sessions on reproduction, sex chromosomes, aneuploidy and meiosis and was, to the best of our knowledge, first repo...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000079575
更新日期:2004-01-01 00:00:00
abstract::Variations of gene copy number in the human genome are increasingly recognized as a genetic factor in phenotypic variation. Human CC chemokine ligand 3-like 1 gene (CCL3L1), which is located on human chromosome 17q11.2, is highly variable in copy number owing to having a hot spot for segmental duplications. CCL3L1, a ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000184703
更新日期:2008-01-01 00:00:00
abstract::Rye B chromosomes (Bs) have strong parasitic effects on fertility. B carrying plants are less fertile than 0B ones, whereas the Bs have no significant effects on plant vigour. On the other hand, it has been reported that B transmission is under genetic control in such a way that H line plants transmit the Bs at high f...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000079316
更新日期:2004-01-01 00:00:00
abstract::The Congo African grey parrot (Psittacus erithacus, PER) is an endemic species of Central Africa, valued for its intelligence and listed as vulnerable due to poaching and habitat destruction. Improved knowledge about the P. erithacus genome is needed to address key biological questions and conservation of this species...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000444136
更新日期:2015-01-01 00:00:00
abstract::Rubus yellow net virus (RYNV) infects Rubus spp., causing a severe decline when present in mixed infections with other viruses. RYNV belongs to the family Caulimoviridae, also known as plant pararetroviruses, which can exist as episomal or integrated elements (endogenous). Most of integrated pararetroviruses are nonin...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000509845
更新日期:2020-01-01 00:00:00
abstract::Scapinin has been found to bind to cytoplasmic actin and is also a putative regulatory subunit of protein phosphatase-1 (PP1). It is found attached to the nuclear matrix-intermediate filament (NM-IF) and is down-regulated by differentiation of tumor cells. We have analyzed the genomic structure and tissue-specific exp...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000094797
更新日期:2006-01-01 00:00:00
abstract::Using FISH and RH mapping a chromosomal map of rat chromosome 10 (RNO10) was constructed. Our mapping data were complemented by other published data and the final map was compared to maps of mouse and human chromosomes. RNO10 contained segments homologous to mouse chromosomes (MMU) 11, 16 and 17, with evolutionary bre...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000063052
更新日期:2002-01-01 00:00:00
abstract::We have identified LIM-kinase (LIMK1 and LIMK2), the only known catalytic protein among LIM-family molecules. Both LIMK1 and LIMK2 phosphorylate (inactivate) cofilin, an actin depolymerizing factor, and induce actin cytoskeleton reorganization. We as well as others concurrently demonstrated that LIMK activation was re...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000076815
更新日期:2003-01-01 00:00:00
abstract::Stripe rust (Puccinia striiformis tritici (Pst)) is one of the most destructive diseases of wheat in the world. Exploiting and utilizing stripe rust resistance genes of wild species has become an essential strategy for resistance breeding. Psathyrostachyshuashanica Keng ex Kuo is a wild species in Triticeae that has b...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000324928
更新日期:2011-01-01 00:00:00
abstract::The suborder Serpentes is divided into 2 infraorders, Scolecophidia and Alethinophidia, which diverged at an early stage of snake diversification. In this study, we examined karyotypes of 4 scolecophidian species (Letheobia simonii, Xerotyphlops vermicularis, Indotyphlops braminus, and Myriopholis macrorhyncha) and pe...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000496554
更新日期:2019-01-01 00:00:00
abstract::Transposable elements are disproportionately abundant in the heterochromatin of Drosophila melanogaster. Among the forces contributing to this bias in genomic distribution, fixation due to positive selection has been put forward. We have studied I-related elements which are located in pericentromeric heterochromatin a...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000084950
更新日期:2005-01-01 00:00:00