Effect of water-soluble reduced chitosan on Streptococcus mutans, plaque regrowth and biofilm vitality.

Abstract:

:The purpose of the present study was to examine the effects of a newly developed water-soluble reduced chitosan on Streptococcus mutans, plaque regrowth, and biofilm vitality. A 1.0%, water-soluble reduced chitosan, with pH ranging from 6.0 to 6.5, molecular weights between 3,000 and 5,000 Da, and 70% degree of deacetylation, was used. To determine antibacterial and antiplaque potency of chitosan, minimal inhibitory concentrations (MICs) for S. mutans and S. sanguinis (formerly S. sanguis), short-term exposure to S. mutans, and clinical trial of plaque regrowth and biofilm vitality were conducted. Twelve dental students volunteered to participate in the 6-week, double blind, randomized clinical trial using the classical 4-day plaque regrowth design. The MIC of water-soluble reduced chitosan for S. mutans was 1.25 g/l. While the cells exposed to distilled water (DW) grew rapidly, with a maximum turbidity reached by 16 h postinoculation, S. mutans exposed to chitosan (5.0 g/l) exhibited a substantial delay in growth and reached a maximum turbidity by 32 h postinoculation. The chitosan solution reduced the plaque index and the vitality of the plaque flora significantly when compared to DW, but this was less than the reductions found with the positive control of 0.1% chlorhexidine solution. The water-soluble reduced chitosan exhibited potent antibacterial effect on S. mutans, and displayed a significant antibacterial and plaque-reducing action during the 4-day plaque regrowth.

journal_name

Clin Oral Investig

authors

Bae K,Jun EJ,Lee SM,Paik DI,Kim JB

doi

10.1007/s00784-006-0038-3

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

102-7

issue

2

eissn

1432-6981

issn

1436-3771

journal_volume

10

pub_type

杂志文章,随机对照试验
  • Do resin-based composite CAD/CAM blocks release monomers?

    abstract:OBJECTIVE:The present study aimed to identify and quantify the elution of monomers of five different resin-based CAD/CAM blocks (RCBs) using HPLC. METHODS:Five different RCBs were used in the study: GC Cerasmart (CS), Voco Grandio blocs (GR), 3M Lava Ultimate (LU), Shofu Block (SB), and Vita Enamic (VE). Fifteen sampl...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-020-03377-3

    authors: Barutcigil K,Dündar A,Batmaz SG,Yıldırım K,Barutçugil Ç

    更新日期:2021-01-01 00:00:00

  • Impact of the intraoral location on the rate of biofilm growth.

    abstract::The aims of the present study were: a) to assess the impact of the intraoral location on the rate of biofilm growth, and b) to establish an in vivo biofilm model to examine intraoral biofilm growth. Eight healthy volunteers wore acrylic splints with 15 glass slabs each in the upper and lower jaws to build up plaque. A...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-004-0255-6

    authors: Auschill TM,Hellwig E,Sculean A,Hein N,Arweiler NB

    更新日期:2004-06-01 00:00:00

  • Lateral static overload on immediately restored implants decreases the osteocyte index in peri-implant bone: a secondary analysis of a pre-clinical study in dogs.

    abstract:OBJECTIVES:This animal study was conducted to evaluate the osteocyte index in the peri-implant bone around immediately restored implants under static lateral overload. MATERIAL AND METHODS:Seven mongrel dogs received three implants on each side of the mandible. Forty-two implants were distributed into three groups (14...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-020-03662-1

    authors: de Calais CD,Bordin D,Piattelli A,Iezzi G,Negretto A,Shibli JA

    更新日期:2020-11-05 00:00:00

  • Gene expression profile of compressed primary human cementoblasts before and after IL-1β stimulation.

    abstract:OBJECTIVES:Root resorptions due to a reduced repair function of cementoblasts are common side effects during orthodontic tooth movement (OTM). The mechanisms, which lead to an impaired cementoblast function, are not fully understood. Therefore, we aimed to investigate changes in the gene expression of cementoblasts dur...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-013-1167-0

    authors: Diercke K,Zingler S,Kohl A,Lux CJ,Erber R

    更新日期:2014-11-01 00:00:00

  • Human periodontal ligament fibroblasts stimulated by nanocrystalline hydroxyapatite paste or enamel matrix derivative. An in vitro assessment of PDL attachment, migration, and proliferation.

    abstract::We determined the effects of soluble or coated nanocrystalline hydroxyapatite paste (nano-HA) and enamel matrix derivative (EMD) on proliferation, adhesion, and migration of periodontal ligament fibroblasts (PDLs). Cultured PDLs were stimulated with nano-HA paste or EMD in a soluble form or were coated to the surface ...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-011-0570-7

    authors: Kasaj A,Willershausen B,Junker R,Stratul SI,Schmidt M

    更新日期:2012-06-01 00:00:00

  • The effect of radiotherapy on dental hard tissue--a systematic review.

    abstract:INTRODUCTION:Decay of teeth, erosion and disintegration of hard dental tissue are a clinically often seen side effect after radiotherapy for tumours in the head and neck region. To investigate if these side effects are due to structural changes in dental hard tissues, the current literature was searched. It can influen...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,评审

    doi:10.1007/s00784-013-1034-z

    authors: Lieshout HF,Bots CP

    更新日期:2014-01-01 00:00:00

  • Changes in mastication after an immediate loading implantation with complete fixed rehabilitation.

    abstract:OBJECTIVE:This study aimed to measure modifications of mastication after immediate loading full-arch prosthesis (ILFAP) rehabilitation. MATERIALS AND METHOD:Fourteen patients were observed before and 6 months after ILFAP rehabilitation when masticating two natural, standardized foods (peanut and carrot) and three mode...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-012-0787-0

    authors: Veyrune JL,Opé S,Nicolas E,Woda A,Hennequin M

    更新日期:2013-05-01 00:00:00

  • Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review of the literature.

    abstract:OBJECTIVES:The aim of this systematic review was to assess the efficacy of bioactive glass (BG) in bone regeneration for implant site development procedures. MATERIAL AND METHODS:The following specific question was formulated with reference to Population, Intervention, Control, Outcomes (PICO): "In persons that underg...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,评审

    doi:10.1007/s00784-014-1376-1

    authors: Ioannou AL,Kotsakis GA,Kumar T,Hinrichs JE,Romanos G

    更新日期:2015-03-01 00:00:00

  • Establishment and validation of a predictive nomogram for extended operation time following mandibular third molar removal.

    abstract:OBJECTIVES:To develop and evaluate predictive nomogram for extended duration of surgery in patients following mandibular third molars (M3M) removal. MATERIALS AND METHODS:A retrospectively observational study was performed and designed. A credible random split-sample method was used to divide data into training and va...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-020-03499-8

    authors: Qiao F,He B,Zhang J,Sun J,Dong R,Zhang X

    更新日期:2020-08-10 00:00:00

  • Children's toothbrush contamination in day-care centers: how to solve this problem?

    abstract:OBJECTIVE:To evaluate the contamination level of toothbrushes by mutans streptococci (MS) and the efficacy of antimicrobial solutions: cetylpyridinium chloride 0.05 % (CPC; Cepacol™) and chlorhexidine 0.12 % (CHX; Periogard™), to disinfect toothbrushes of preschool-aged children in day-care centers. MATERIAL AND METHO...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00784-013-1169-y

    authors: Nelson-Filho P,Pereira MS,De Rossi A,da Silva RA,de Mesquita KS,de Queiroz AM,da Silva LA

    更新日期:2014-11-01 00:00:00

  • Osteogenic gene array of osteoblasts cultured on a novel osteoinductive biphasic calcium phosphate bone grafting material.

    abstract:OBJECTIVES:Recently, novel biphasic calcium phosphate (BCP) scaffolds have emerged as a new class of bone grafts with osteoinductive potential demonstrating the ability to form ectopic bone in extra-skeletal sites. The aim of the present study was to perform an osteogenic gene array to target possible genes responsible...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-016-1825-0

    authors: Miron RJ,Shuang Y,Bosshardt DD,Caballé-Serrano J,Chandad F,Zhang Y

    更新日期:2017-04-01 00:00:00

  • Randomised study for the 1-year crestal bone maintenance around modified diameter implants with different loading protocols: a radiographic evaluation.

    abstract::This study evaluated by standardised digitised periapical radiography the crestal bone maintenance around modified diameter internal hex implants with variable thread design and narrow neck loaded with different procedures. Forty implants were placed in 25 patients. Twenty implants were conventionally loaded, 20 ones ...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00784-009-0314-0

    authors: Danza M,Tortora P,Quaranta A,Perrotti V,Vozza I,Piattelli A

    更新日期:2010-08-01 00:00:00

  • Effect of root surface treatment with denusomab after delayed tooth replantation.

    abstract:OBJECTIVES:To evaluate denosumab, a human monoclonal antibody that mimics the effects of osteoprotegerin in bone metabolism, as a topical treatment of root surface to be used prior to delayed tooth replantation. MATERIALS AND METHODS:Thirty-six rats' right incisors were used. Teeth were extracted and divided into: del...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-020-03430-1

    authors: da Silva LAB,Longo DL,Stuani MBS,de Queiroz AM,da Silva RAB,Nelson-Filho P,Vieira HAO,Pucinelli CM,Paula-Silva FWG

    更新日期:2020-07-29 00:00:00

  • Anesthetic efficacies of intrapapillary injection in comparison to inferior alveolar nerve block for mandibular premolar extraction: a randomized clinical trial.

    abstract:OBJECTIVE:Intrapapillary injection (IPI) has been suggested to improve pulpal anesthesia of mandibular teeth and to avoid complications from inferior alveolar nerve block (IANB). This study aimed to determine and compare clinical efficacies and prostaglandin E2 (PGE2) levels between IPI and IANB. MATERIALS AND METHODS...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00784-019-02954-5

    authors: Wongpang D,Makeudom A,Sastraruji T,Khongkhunthian S,Krisanaprakornkit S,Supanchart C

    更新日期:2020-02-01 00:00:00

  • Masticatory rehabilitation following upper and lower jaw reconstruction using vascularised free fibula flap and enossal implants-19 years of experience with a comprehensive concept.

    abstract:OBJECTIVES:Conventional prosthesis is generally inapplicable following reconstruction with free fibula flaps (FFF) due to impaired bone and soft tissue conditions, and rehabilitation via enossal implants in FFF is relatively novel. This retrospective study aimed to document the surgical aspects of this option and to de...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-014-1247-9

    authors: Hakim SG,Kimmerle H,Trenkle T,Sieg P,Jacobsen HC

    更新日期:2015-03-01 00:00:00

  • The eligibility of the free fibula graft for masticatory rehabilitation using monocortical implants insertion--a morphologic and biomechanical study.

    abstract::The use of the vascularized fibula graft has already been established for reconstruction of the mandible following ablative surgery. In order to reconstruct the vertical height of the alveolar process and improve implant position as well as angulation, some therapeutic options are available, including primary use of t...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-011-0582-3

    authors: Hakim SG,Jeske G,Jacobsen HC,Sieg P

    更新日期:2012-04-01 00:00:00

  • Effect of different gutta-percha solvents on the microtensile bond strength of various adhesive systems to pulp chamber dentin.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effect of different endodontic solvents on the microtensile bond strength (μTBS) of various adhesives to pulp chamber dentin. MATERIAL AND METHODS:A total of 120 human third molars were selected. Canals were prepared with the ProTaper Universal system and obturated....

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-016-1929-6

    authors: Demırbuga S,Pala K,Topçuoğlu HS,Çayabatmaz M,Topçuoğlu G,Uçar EN

    更新日期:2017-03-01 00:00:00

  • Autotransplantation of teeth in humans: a systematic review and meta-analysis.

    abstract:OBJECTIVES:The aim of this investigation was to assess the currently available evidence concerning the complications and risk factors influencing the outcome of autotransplantation of teeth in humans. MATERIALS AND METHODS:Electronic searches were conducted to identify randomized controlled and prospective clinical tr...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00784-015-1473-9

    authors: Almpani K,Papageorgiou SN,Papadopoulos MA

    更新日期:2015-07-01 00:00:00

  • Analysis of the intraimplant microflora of two-piece dental implants.

    abstract:OBJECTIVE:Information about the spectrum of microorganisms in the intraimplant cavities of two-piece dental implants is scarce. The purpose of this study was to assess the intraimplant microflora of two-piece dental implants by conventional biochemical testing, matrix-assisted laser desorption/ionization time-of-flight...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-012-0805-2

    authors: Harder S,Podschun R,Grancicova L,Mehl C,Kern M

    更新日期:2013-05-01 00:00:00

  • Expression patterns of immune genes in long-term cultured dental stem cells.

    abstract:BACKGROUND AND OBJECTIVES:Long-term culture system is used to prevent the impediment of insufficient cells and is good for low starting materials such as dental pulp or periodontal ligament. In general, although cell viability and functionality are the most common aspects taken into consideration in culturing cells for...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-015-1497-1

    authors: Jayaraman P,Govindasamy V,Gnanasegaran N,Kunasekaran W,Vasanthan P,Musa S,Kasim NH

    更新日期:2016-01-01 00:00:00

  • Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial.

    abstract:OBJECTIVES:In this single-blinded, prospective, randomized, controlled clinical trial, the effectiveness of an ozone gas or NaOCl/CHX disinfection protocol was compared within the root canal treatment of apical periodontitis. MATERIALS AND METHODS:Sixty permanent teeth were randomly allocated to one technique. The cli...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00784-016-1849-5

    authors: Kist S,Kollmuss M,Jung J,Schubert S,Hickel R,Huth KC

    更新日期:2017-05-01 00:00:00

  • A combination of alleles 2 of interleukin (IL)-1A(-889) and IL-1B(+3954) is associated with lower gingival bleeding tendency in plaque-induced gingivitis in young adults of Arabic heritage.

    abstract::The aim of this study was to investigate the possible association of a distinct combination of polymorphisms in the interleukin (IL)-1 gene cluster on gingival bleeding tendency in young adult Arabs with plaque-induced gingivitis. Fifty otherwise healthy, nonsmoking volunteers, 19-28 years of age, participated. Clinic...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-007-0120-5

    authors: Müller HP,Barrieshi-Nusair KM

    更新日期:2007-09-01 00:00:00

  • Functional characterization of the parathyroid hormone 1 receptor in human periodontal ligament cells.

    abstract:OBJECTIVES:Intermittent parathyroid hormone (PTH) exerts anabolic effects on bone and has been approved for osteoporosis therapy. The dual actions of PTH are mediated primarily through the parathyroid hormone 1 receptor (PTH1R). Upon ligand binding, PTH1R activates diverse signaling pathways, including cAMP/protein kin...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-013-0985-4

    authors: Abuduwali N,Lossdörfer S,Winter J,Kraus D,Guhlke S,Wolf M,Jäger A

    更新日期:2014-01-01 00:00:00

  • Histotomography of the odontoblast processes at the dentine-enamel junction of permanent healthy human teeth in the confocal laser scanning microscope.

    abstract::The translucency of teeth allows the non-destructive subsurface visualisation of their microstructure by confocal laser scanning microscopy (CLSM) at a level of about 150 microns below the surface. The dentine-enamel junction (DEJ) is accessible only directly adjacent to the cervix of the tooth. Therefore teeth have t...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s007840050038

    authors: Grötz KA,Duschner H,Reichert TE,de Aguiar EG,Götz H,Wagner W

    更新日期:1998-03-01 00:00:00

  • Identification and characterization of estrogen-like components in commercial resin-based dental restorative materials.

    abstract::Recently, resin-based dental restorative materials have been targeted as potential sources of xenoestrogens, specifically bisphenol A (BPA) and bisphenol A dimethacrylate (BAD), which could contribute to overall estrogen load and result in deleterious side effects. The present study used high-pressure liquid chromatog...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s007840050087

    authors: Lewis JB,Rueggeberg FA,Lapp CA,Ergle JW,Schuster GS

    更新日期:1999-09-01 00:00:00

  • Wound healing of dehiscence defects following different root conditioning modalities: an experimental study in dogs.

    abstract:OBJECTIVE:The purpose of this study was to investigate the periodontal healing pattern of dehiscence-type defects following different chemical root conditioning modalities. MATERIALS AND METHODS:Buccal osseous dehiscence defects were created on six teeth of seven dogs. After dental plaque accumulation, defects were tr...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-012-0848-4

    authors: Zandim DL,Leite FR,da Silva VC,Lopes BM,Spolidorio LC,Sampaio JE

    更新日期:2013-07-01 00:00:00

  • Evaluation and characteristics of "dropouts" in a longitudinal clinical study.

    abstract::This paper attempts to identify characteristics of a longitudinal clinical study's "dropout" population (1974-1996) of patients using overdentures. This study included 395 subjects. Dropouts were identified as persons who did not respond to letters or telephone calls after participating in the study for up to 2 years,...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-003-0238-z

    authors: Ettinger RL,Qian F,Xie XJ,Watkins CA

    更新日期:2004-03-01 00:00:00

  • Interdental papilla loss: treatment by hyaluronic acid gel injection: a case series.

    abstract:OBJECTIVES:The purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND METHODS:Ten systemically healthy adults, with at least on...

    journal_title:Clinical oral investigations

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00784-015-1677-z

    authors: Awartani FA,Tatakis DN

    更新日期:2016-09-01 00:00:00

  • The role of Candida albicans hyphae and Lactobacillus in denture-related stomatitis.

    abstract::Denture-related stomatitis (DRS) is still a dilemma in removable prosthodontics. The aim of this study was to investigate the relationship of DRS with the presence of Candida albicans hyphae and Lactobacillus. A total of 91 patients wearing maxillary and mandibular complete dentures were included in the present study ...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-008-0240-6

    authors: Bilhan H,Sulun T,Erkose G,Kurt H,Erturan Z,Kutay O,Bilgin T

    更新日期:2009-12-01 00:00:00

  • DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region.

    abstract:OBJECTIVES:To explore whether a computed tomography (CT) examination of the head and neck region induces biological damage and whether the damage was correlated with the radiation dose. MATERIALS AND METHODS:Peripheral blood was taken from 33 individuals who received head and neck CT examinations. Blood samples were d...

    journal_title:Clinical oral investigations

    pub_type: 杂志文章

    doi:10.1007/s00784-020-03331-3

    authors: Yang P,Wang S,Liu D,Zhao H,Li G

    更新日期:2020-12-01 00:00:00