Abstract:
OBJECTIVES:To evaluate denosumab, a human monoclonal antibody that mimics the effects of osteoprotegerin in bone metabolism, as a topical treatment of root surface to be used prior to delayed tooth replantation. MATERIALS AND METHODS:Thirty-six rats' right incisors were used. Teeth were extracted and divided into: delayed replantation without root surface treatment (control); delayed replantation with root surface treatment with denosumab 60 mg/mL and 30 mg/mL, respectively, for 10 min both experimentals groups. After that, the root canals were filled with calcium hydroxide and replanted. After 15 and 60 days, the animals were euthanized, and the samples were collected and processed for microscopic analysis. Histological sections were performed, and stained with HE to describe the dental characteristics, measure ankylosis, replacement resorption, and dental resorption by conventional microscopy. Also, was performed Brown & Brenn staining and immunohistochemistry for RANKL, OPG, and periostin. RESULTS:Denosumab 60 mg/mL reducted ankylosis (p < 0.0001), replacement resorption (p < 0.0001), and tooth resorption, 60 days after replantation, compared to untreated replanted teeth (p < 0.005). Lower bacterial contamination in root surface in the denosumab treatment groups was found, regardless of the concentration used (p < 0.001). Also, denosumab treatment inhibited the expression of RANKL without modulating OPG. Periostin was observed in periodontal ligament of replanted tooth, although this labelling was absent in the ankylosis areas, in both experimental periods. CONCLUSION:Treatment of the root surface with denosumab at 60 mg/mL of rat teeth before delayed replantation reduced dental root resorption compared with the untreated teeth after 60 days. CLINICAL RELEVANCE:Survival of a replanted tooth has been a challenge in clinical practice. The use of a medication, such as denosumab, to limit dental root resorption represents an important therapeutical approach.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
da Silva LAB,Longo DL,Stuani MBS,de Queiroz AM,da Silva RAB,Nelson-Filho P,Vieira HAO,Pucinelli CM,Paula-Silva FWGdoi
10.1007/s00784-020-03430-1subject
Has Abstractpub_date
2020-07-29 00:00:00eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03430-1pub_type
杂志文章abstract:: ...
journal_title:Clinical oral investigations
pub_type: 评论,信件
doi:10.1007/s00784-018-2636-2
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. MATERIAL AND METHODS:We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from th...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03575-z
更新日期:2020-09-11 00:00:00
abstract:OBJECTIVES:The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. MATERIAL AND METHODS:Sixty patients (ASA I) were scheduled for lower third molar su...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1114-0
更新日期:2014-01-01 00:00:00
abstract::Aim of this investigation was to evaluate the validity and reproducibility of the universal visual scoring systems (UniViSS) on occlusal surfaces in vitro. The validity study included 65 third molars. Following to reach a UniViSS consensus diagnosis for each surface, all teeth were histologically prepared and evaluate...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0390-1
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:To describe the number of second primary malignancies in a series of 33 patients with proliferative verrucous leukoplakia (PVL), detailing the mean time between primary malignancies and their clinical characteristics. MATERIALS AND METHODS:Two groups of patients were included in this study: group 1 comprise...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03059-9
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:Candida albicans is the most common fungal pathogen in humans, but other Candida species cause candidosis. Candida species display significant differences in their susceptibility to antimycotic drugs. Patients with symptomatic or erythematous oral lichen planus (OLP) commonly have Candida infection requiring...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0757-6
更新日期:2013-04-01 00:00:00
abstract::The use of oral implants opened a wide range of prosthetic treatment possibilities in edentulous patients. Although the reported success rates of oral implants are high, failures do occur. This paper reviews the current knowledge about the aetiology, the signs and symptoms and the possible influencing factors of impla...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s007840050054
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:This in situ study aims to evaluate the effects of chlorhexidine (CHX) mouth rinsing on biofilm formation and moreover on the disruption of existing mature dental biofilms. METHODS:Biofilms were formed in situ by five volunteers on bovine enamel specimens fixed to individual acrylic splints. For biofilm for...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03250-3
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine reports of perceptual distortion evoked by transient deafferentation and burning pain as models of aspects of burning mouth syndrome (BMS). MATERIALS AND METHODS:Sixteen healthy women took part in three experimental sessions that included exposure to lingual nerve block,...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1994-x
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess current opinions, applied techniques, and materials for the restoration of endodontically treated teeth (ETT) in a nationwide survey in Germany. MATERIAL AND METHODS:Completed questionnaires from 1,648 dentists were returned (response rate 63%). RESULTS:In general, po...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1505-5
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the effects of periodontal treatment on the inflammatory markers in gingival crevicular fluid and the concentration of salivary cortisol between non-pregnant and pregnant women with gingivitis. MATERIALS AND METHODS:This study included 30 non-pregnant women (mean age 27....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2569-9
更新日期:2018-07-31 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence, clinical features, and risk factors of dentin hypersensitivity (DH) in a Brazilian population. MATERIALS AND METHODS:300 patients at the Dentistry Clinic of the University of São Paulo participated in this study. The subjects completed a questionnaire regarding their personal inf...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1008-1
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Conventional prosthesis is generally inapplicable following reconstruction with free fibula flaps (FFF) due to impaired bone and soft tissue conditions, and rehabilitation via enossal implants in FFF is relatively novel. This retrospective study aimed to document the surgical aspects of this option and to de...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1247-9
更新日期:2015-03-01 00:00:00
abstract:AIM:The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6-13 years using inferior alveolar nerve block. METHODS:A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% arti...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2775-5
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To assess dimensional changes following alveolar ridge preservation using bovine-derived xenograft with 10% collagen and collagen membrane compared to ridge preservation by means of bovine-derived xenograft particles and collagen membrane or spontaneous healing in posterior sites. MATERIALS AND METHODS:Fort...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-019-02979-w
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The aim of this comprehensive literature review is to provide recommendations and guidelines for dental implant therapy in patients with a history of radiation in the head and neck region. For the first time, a meta-analysis comparing the implant survival in irradiated and non-irradiated patients was perform...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00784-013-1134-9
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:Intermittent parathyroid hormone (PTH) exerts anabolic effects on bone and has been approved for osteoporosis therapy. The dual actions of PTH are mediated primarily through the parathyroid hormone 1 receptor (PTH1R). Upon ligand binding, PTH1R activates diverse signaling pathways, including cAMP/protein kin...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0985-4
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to validate the reproducibility and observer variability of the Functional Implant Prosthodontic Score (FIPS), while considering the level of dental experience for intra- and inter-examiner analysis. MATERIALS AND METHODS:A total of 44 examiners (n = 31 undergraduate dental student...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2332-7
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the role of hyperbaric oxygen (HBO) in the healing of teeth extraction sockets and in alveolar ridge preservation. This may provide an experimental basis for the widespread application of HBO in oral implantation. METHODS:A total of 32 beagle dogs were included i...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03117-2
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to quantify the symmetry of the alveolar process of the maxilla and palate during the first year of life in healthy infants with the help of a semiautomatic segmentation technique. MATERIALS AND METHODS:Maxillary plaster models of seventy healthy babies at 0, 3, 6, 9, and 12 mo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03403-4
更新日期:2020-06-24 00:00:00
abstract::The objective of this prospective clinical follow-up was to evaluate the 2-year clinical performance of a nanofilled resin composite in class II restorations. The restorations were made with and without intermediary layer of a nanofilled flowable resin composite studied in an intraindividual comparison. Each participa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-010-0485-8
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Intrapapillary injection (IPI) has been suggested to improve pulpal anesthesia of mandibular teeth and to avoid complications from inferior alveolar nerve block (IANB). This study aimed to determine and compare clinical efficacies and prostaglandin E2 (PGE2) levels between IPI and IANB. MATERIALS AND METHODS...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-019-02954-5
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess postoperative pain in a prospective randomized clinical trial comparing two groups, using the Reciproc® system in one group and the ProTaper® rotary system in the other. MATERIAL AND METHODS:The study included 78 male patients, aged 18-64 years (mean age of 26 years), wit...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-015-1692-0
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:This study compared the effects of mold material and diameter on the thickness of cured composite remnants and depth of cure (DOC) of resin-based composites (RBC). MATERIAL AND METHODS:One Polywave® curing light was used to photo-cure two shades of the same "bulk-fill" RBC in 4, 6, or 10-mm internal diameter...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1672-4
更新日期:2016-09-01 00:00:00
abstract::The objectives of this study were to evaluate the results of guided tissue regeneration (GTR) treatment of intrabony defects with two kinds of bioresorbable membranes, with deproteinized bovine bone (Bio-Oss) used as an adjunct. Twenty-eight patients with at least one intrabony defect with a probing pocket depth (PPD)...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00784-004-0277-0
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate factors associated with the incidence of erosive tooth wear (ETW) among adults at different ages in Tokyo using multifactorial logistic regression analysis. MATERIALS AND METHODS:The study sample consisted of a total of 1108 subjects aged 15 to 89 years in Tokyo, Japan....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2065-7
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the effects of a hemostatic collagen sponge and a collagen sponge sealed with a bio-adhesive material on the palatal donor sites with the purpose of minimizing postoperative pain after epithelialized gingival graft (EGG) harvesting. MATERIAL AND METHODS:The present study...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2455-5
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the onset, success rate, injection pain, and post-injection pain of mental/incisive nerve block (MINB) with that of inferior alveolar nerve block (IANB) using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis. The accuracy of electrical pulp test...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2500-4
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Although dental trauma and its unfavorable sequelae are considered major public health problems worldwide, the published data on the prevalence of traumatic crown injuries (TCIs) in Germany are lacking. Therefore, the present study assessed the prevalence of TCIs among adolescents in Bavaria, Germany. MATER...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02974-1
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to evaluate the elemental release from a Ni-Cr dental casting alloy subjected to 10% hydrogen peroxide (HP) or 10% carbamide peroxide (CP) solutions and to determine the composition of surface oxide layer formed on alloy samples. Cylinder-shaped 15 specimens were cast from a Ni-Cr alloy and d...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0391-0
更新日期:2011-06-01 00:00:00