Cross-reactivity between thiurams.

Abstract:

:Retesting with an allergen at a site with previous allergic contact dermatitis has been shown to enhance reactivity. It has been suggested that retesting with a cross-reactive allergen will also induce hyperreactivity. Concurrent sensitization to more than 1 thiuram is common, but whether this is due to concomitant primary sensitization or cross-reactivity is uncertain. The aim of this study was to investigate the use of retesting to distinguish between concomitant sensitization and cross-reactivity in the rubber chemicals tetraethylthiuram disulphide (TETD) and tetramethylthiuram disulphide (TMTD). There was a non-significant trend towards enhanced reactivity for both TETD and TMTD when testing in an area with previous allergic contact dermatitis due to TETD. Cross-reactivity between the 2 chemicals is likely, but a definite conclusion from this pilot study is not possible.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Lerbaek A,Menné T,Knudsen B

doi

10.1111/j.0105-1873.2006.00785.x

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

165-8

issue

3

eissn

0105-1873

issn

1600-0536

pii

COD785

journal_volume

54

pub_type

杂志文章
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