Effect of an antioxidant (quercetin) on sodium-lauryl-sulfate-induced skin irritation.

Abstract:

:Quercetin is a bioflavonoid with antioxidant and anti-inflammatory activity. The purpose of this study was to examine the effect of quercetin on acute skin irritation, with special interest in the skin barrier function recovery. Acute irritant contact dermatitis was induced in 15 patients by 24-h occlusion of 2% sodium lauryl sulfate (SLS) (day (D) 1). The influence of application on SLS-irritated skin of topical quercetin for 5 consecutive Ds, compared to vehicle and controls, was studied. Parameters measured were transepidermal water loss (TEWL) and erythema index. Final measurements were taken on D 7 after a 1-D rest period. TEWL and the erythema index continued to rise 2 D after application of SLS and 1 D after treatment with quercetin, vehicle or controls. Both TEWL and erythema values at D 7 did not return to values before the SLS barrier disruption at all the test sites. Therefore, quercetin topically applied after induction of irritant contact dermatitis does not appear to increase the recovery of barrier function and erythema caused by SLS.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Katsarou A,Davoy E,Xenos K,Armenaka M,Theoharides TC

doi

10.1034/j.1600-0536.2000.042002085.x

keywords:

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

85-9

issue

2

eissn

0105-1873

issn

1600-0536

journal_volume

42

pub_type

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