Effect of test techniques of perfusion of neomycin sulfate patch tests. A comparative study with visual assessments.

Abstract:

:Effects of test techniques on neomycin patch test results have not been thoroughly investigated. This study focuses on effects of dose and application time of neomycin sulfate patch tests on test results. The effects are assessed both visually and by perfusion. 16 subjects positive to neomycin are retested with neomycin sulfate in various doses and vehicles applied with different application devices for variable time intervals. All subjects were tested with a serial-dose series for time intervals ranging from 3 to 96 h (4 days [D]). The results show very good agreement between perfusion assessments and positive and negative visual assessments of reactions; however, a gray zone was detected where reactions with variable perfusion were associated with visually questionable test responses. 1:27 serial dilutions and wide application time intervals show a positive response with perfusion assessments and partly with visual assessments. Regardless of reading technique, highest reactivity of reactions was detected at either 96 h (day [D] 4) or 168 h (D7) in each subject with minor exceptions, regardless of dose, vehicle, application device or application time. Some findings of the study support the idea that reactions with papules alone are positive tests. Possible effect of tapes and foils on test results are discussed.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Bjarnason B,Flosadóttir E

doi

10.1034/j.1600-0536.2000.043005283.x

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

283-94

issue

5

eissn

0105-1873

issn

1600-0536

journal_volume

43

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::A 30-year-old male developed asthma and pruritus after using an insecticidal spray (Pyrex). The same symptoms appeared with an alcoholic skin disinfectant (M-sprit) and other spirituous preparations denaturated with denatonium benzoate (Bitrex). An open epicutaneous test (20 min) showed wheal and erythema to Pyrex, M-...

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    doi:10.1111/j.1600-0536.1980.tb05568.x

    authors: Björkner B

    更新日期:1980-12-01 00:00:00

  • Scarified photopatch testing in lomefloxacin photosensitivity.

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    doi:10.1111/j.1600-0536.1992.tb00860.x

    authors: Kurumaji Y,Shono M

    更新日期:1992-01-01 00:00:00

  • The vulvar epithelium differs from the skin: implications for cutaneous testing to address topical vulvar exposures.

    abstract::Vulvar tissue is more permeable than exposed skin due to differences in structure, occlusion, hydration and susceptibility to friction. The safety assessment of products that contact the vulva should account for this potentially heightened permeability. Standard clinical patch tests may not sufficiently mimic vulvar e...

    journal_title:Contact dermatitis

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    doi:10.1111/j.0105-1873.2004.00444.x

    authors: Farage M,Maibach HI

    更新日期:2004-10-01 00:00:00

  • Self-reported skin disease in hydrotherapists working in swimming pools.

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    journal_title:Contact dermatitis

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    doi:10.1111/j.0105-1873.2005.00699.x

    authors: Lazarov A,Nevo K,Pardo A,Froom P

    更新日期:2005-12-01 00:00:00

  • Coin exposure may cause allergic nickel dermatitis: a review.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.2012.02127.x

    authors: Thyssen JP,Gawkrodger DJ,White IR,Julander A,Menné T,Lidén C

    更新日期:2013-01-01 00:00:00

  • An outbreak of contact dermatitis from toluenesulfonamide formaldehyde resin in a nail hardener.

    abstract::8 cases of contact dermatitis from toluenesulfonamide formaldehyde resin in a nail hardener are presented. Most patients had used nail lacquers containing this resin for many years without trouble, but became sensitized to the resin shortly after the introduction of this particular nail hardener. A hypothesis concerni...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1988.tb02833.x

    authors: de Wit FS,de Groot AC,Weyland JW,Bos JD

    更新日期:1988-05-01 00:00:00

  • Addressing the conundrums of p-phenylenediamine hair dye allergy by applying Friedmann's principles of contact sensitization.

    abstract::In the first conundrum, permanent hair dyeing involves the use of aromatic amines such as p-phenylenediamine (PPD), whose oxidation is pivotal to the dyeing process, but also generates potent allergens. Despite prolonged efforts by industry to search for safer alternatives, hair dyeing is still reliant on this type of...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.13171

    authors: Ferguson FJ,Pongpairoj K,Basketter DA,White IR,McFadden JP

    更新日期:2019-04-01 00:00:00

  • Hand eczema in car mechanics.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1994.tb00692.x

    authors: Meding B,Barregård L,Marcus K

    更新日期:1994-03-01 00:00:00

  • Skin condition associated with intensive use of alcoholic gels for hand disinfection: a combination of biophysical and sensorial data.

    abstract::Although hand hygiene is an important and inexpensive measure to prevent nosocomial infections in clinical settings, the compliance of healthcare workers remains low. In Europe, alcoholic hand disinfection is first choice, but there exists a limited user acceptability due to estimated adverse effects on skin condition...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.0105-1873.2006.00817.x

    authors: Houben E,De Paepe K,Rogiers V

    更新日期:2006-05-01 00:00:00

  • Delayed hypersensitivity drug reactions diagnosed by patch testing.

    abstract::Drug reactions are a common problem in hospital inpatients and outpatients. Oral or parenteral drug challenges are valuable diagnostic aids, but time consuming. We review attempts to diagnose delayed hypersensitivity drug eruptions by patch testing. We review control data, and offer an operational definition that migh...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1993.tb03555.x

    authors: Calkin JM,Maibach HI

    更新日期:1993-11-01 00:00:00

  • Biochemical and clinical studies in a case of contact urticaria to potato.

    abstract::Contact urticaria to potato was confirmed by skin testing in a 26-year-old male with atopic dermatitis, birch-pollen rhinoconjunctivitis and a history of immediate finger itching upon handling raw potato. The potato peel was non-reactive. The urticarial reactivity to potato could be transferred by the patient's serum ...

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1983.tb04315.x

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    更新日期:1983-03-01 00:00:00

  • Allergic contact dermatitis caused by dexpanthenol-Probably a frequent allergen.

    abstract:BACKGROUND:Panthenol (synonym: dexpanthenol), the alcohol analogue of panthothenic acid, is frequently included in moisturizers, wound-healing agents, and other cosmetics, and has been shown to be responsible for allergic contact dermatitis (ACD). OBJECTIVES:To evaluate the frequency of ACD caused by dexpanthenol, and...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.13054

    authors: Fernandes RA,Santiago L,Gouveia M,Gonçalo M

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  • Occupational contact urticaria caused by cyclic acid anhydrides.

    abstract:BACKGROUND:Cyclic acid anhydrides often cause allergic respiratory diseases, but contact urticaria because of these anhydrides has been considered rare. OBJECTIVE:We describe 21 patients diagnosed with occupational contact urticaria at the Finnish Institute of Occupational Health during the period 1990-2006. METHOD:P...

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2009.01526.x

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    更新日期:2009-02-01 00:00:00

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    doi:10.1111/j.1600-0536.2010.01741.x

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    更新日期:2010-07-01 00:00:00

  • Reduced frequency of atopic dermatitis in quinoline-allergic patients: the 'hapten-atopy hypothesis'.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

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    更新日期:2008-05-01 00:00:00

  • Structure-activity relationships in allergic contact dermatitis induced by methacrylates. Studies of the influence of side-chain length of methacrylates.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1999.tb05971.x

    authors: Kanazawa Y,Yoshida T,Kojima K

    更新日期:1999-01-01 00:00:00

  • Frequency of and trends in fragrance allergy over a 15-year period.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2007.01287.x

    authors: Nardelli A,Carbonez A,Ottoy W,Drieghe J,Goossens A

    更新日期:2008-03-01 00:00:00

  • Patch test reactions to metal salts in patients with oral mucosal lesions associated with amalgam restorations.

    abstract::Patch testing with various metal salts was performed in patients with oral mucosal lesions associated with amalgam restorations, by using polypropylene-coated aluminium discs. Positive reactions to mercuric chloride were obtained in 5/12 (42%) of these patients, but only in 1/11 patients (9%) with oral mucosal lesions...

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    doi:10.1111/j.1600-0536.1992.tb05245.x

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    更新日期:1992-09-01 00:00:00

  • Contact dermatitis. A review.

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  • Contact allergy to petrolatums. (I). Sensitizing capacity of different brands of yellow and white petrolatums.

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    doi:10.1111/j.1600-0536.1983.tb04354.x

    authors: Dooms-Goossens A,Degreef H

    更新日期:1983-05-01 00:00:00

  • Gold trichloride and gold sodium thiosulfate as markers of contact allergy to gold.

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  • Sensitization potential and potency of terpene hydroperoxides in the cocultured activation test method.

    abstract:BACKGROUND:Positive patch test reactions to mixtures of oxidized terpenes containing allergenic hydroperoxides are frequently reported. However, human sensitization data for these hydroperoxides are not available. OBJECTIVES:To analyse and evaluate the human sensitization potential and potency of hydroperoxides in vit...

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    pub_type: 杂志文章

    doi:10.1111/cod.13286

    authors: Hennen J,Silva E Sousa M,Sahli F,Lichter J,Lepoittevin JP,Giménez-Arnau E,Blömeke B

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  • Prevalence and cause of methylisothiazolinone contact allergy.

    abstract:BACKGROUND:Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial products, and the first cases of isolat...

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    doi:10.1111/j.1600-0536.2010.01774.x

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  • Aroma chemicals: Reference sources for perfume and flavour ingredients with special reference to cinnamic aldehyde.

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    doi:10.1111/j.1600-0536.1975.tb05310.x

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  • Contact sensitivity to flavourings and perfumes in atopic dermatitis.

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    doi:10.1111/j.1600-0536.1992.tb05196.x

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    doi:10.1111/cod.12462

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    authors: Halkier-Sørensen L,Thestrup-Pedersen K

    更新日期:1991-07-01 00:00:00