Prevalence and cause of methylisothiazolinone contact allergy.

Abstract:

BACKGROUND:Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial products, and the first cases of isolated MI contact allergy were published. OBJECTIVES:To present the prevalence and causes of MI contact allergy. MATERIALS AND METHODS:Patch test results from 2536 dermatitis patients tested with MI at Gentofte University Hospital between May 2006 and February 2010 were analysed. A retrospective investigation of medical records from MI-allergic patients was performed to reveal the causes of their MI contact allergy. RESULTS:Of patch-tested patients, 1.5% had MI contact allergy. It was associated with occupational dermatitis, hand eczema and age above 40 years. Exposure to MI in cosmetic products was found in 12 (32%) cases, and exposure to MI in occupational products was found in 11 (30%) cases; 5 of the 11 were painters. CONCLUSIONS:The prevalence of MI contact allergy is already at the same level as that of other sensitizing preservatives, which have been on the market for several years, but no rising trend was identified. MI contact allergy was associated with both occupational and consumer products.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Lundov MD,Thyssen JP,Zachariae C,Johansen JD

doi

10.1111/j.1600-0536.2010.01774.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

164-7

issue

3

eissn

0105-1873

issn

1600-0536

pii

COD1774

journal_volume

63

pub_type

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