New concepts in cutaneous allergy.

Abstract:

:Allergic contact dermatitis affects a worrying proportion of the general population. The mechanisms underlying this chemical-triggered delayed-type hypersensitivity are still not fully understood. In recent years, basic research has shown that the immune system reacts to contact allergens by activation of signalling pathways that are usually used to fight infections. Ongoing work is aimed at the elucidation of the path that leads from the chemistry of contact allergens to the inflammatory skin disease. The cellular players and their complex interactions are being characterized. Proteins are being identified whose chemical modification by contact allergens results in the activation of signalling pathways involved in pathogenesis. Pathway identification is supported by genomic and proteomic techniques. All of these efforts will yield a cellular and molecular understanding of the orchestration of the innate and adaptive immune response to contact allergens. This knowledge will help in the identification of gene and protein signatures for improved diagnostics, the identification of novel drug targets for targeted treatments, as well the development of in vitro assays for contact allergen identification.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Martin SF

doi

10.1111/cod.12311

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

2-10

issue

1

eissn

0105-1873

issn

1600-0536

journal_volume

72

pub_type

杂志文章,评审
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    authors: Larkò O,Lindstedt G,Lundberg PA,Mobacken H

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    abstract::To estimate the prevalence of hand eczema, a questionnaire was distributed to 901 male car mechanics. Of the 801 persons who responded, 15% reported hand eczema on some occasion in the previous 12 months, and 57% admitted dry skin on the hands. In a 2nd part of the study, those who reported hand eczema were examined a...

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  • Topical D-vitamins: multiparametric comparison of the irritant potential of calcipotriol, tacalcitol and calcitriol in a hairless guinea pig model.

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    更新日期:2015-05-01 00:00:00

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    doi:10.1111/j.1600-0536.1979.tb04881.x

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    authors: Rudzki E,Rebandel P,Grzywa Z

    更新日期:1989-04-01 00:00:00

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    abstract::A patient was found to have a delayed positive patch test to hydrocortisone on multiple testing. This proved to be due to a photoallergy with an action spectrum in the UV-A range. The patient coincidently had a polymorphous light eruption in the UV-B range. ...

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    doi:10.1111/j.1600-0536.1978.tb03845.x

    authors: Rietschel RL

    更新日期:1978-12-01 00:00:00

  • Prognosis of contact dermatitis in epoxy resin workers.

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    pub_type: 杂志文章

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    authors: Thyssen JP,Engkilde K,Menné T,Johansen JD

    更新日期:2011-08-01 00:00:00

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    authors: van Ulsen J,Stolz E,van Joost T,Geursen-Reitsma AM

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    abstract::The goal of this study was to evaluate biophysically and clinically the hand skin of nurses working in the operating room in comparison with the hand skin of a control group of female administrative employees. 19 nurses and 14 employees were included in this trial. Transepidermal water loss (TEWL) and stratum corneum ...

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    doi:10.1034/j.1600-0536.2002.460406.x

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  • Influence of area of application of allergen on sensitization in contact dermatitis.

    abstract::There are at least 2 quantitative variables when applying allergens to obtain sensitization: the absolute amount of allergen and the surface concentration. This review analyzes the limited studies on surface concentration and determines surface area threshold levels for the allergens documented in the literature. ...

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    pub_type: 杂志文章,评审

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    abstract::The occurrence of occupational contact dermatitis among workers in a rubber factory from 1976 to 1980 was studied. Insurance compensation was paid to 50 workers with dermatitis. 21 of the cases were allergic and 27 toxic contact dermatitis, giving a contact dermatitis frequency of 5.6/1000 workers. Paraphenylenediamin...

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    authors: Kilpikari I

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    doi:10.1111/j.1600-0536.1989.tb04656.x

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    authors: Klas PA,Corey G,Storrs FJ,Chan SC,Hanifin JM

    更新日期:1996-02-01 00:00:00

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    abstract::3 patients with contact dermatitis to an ethyl cyanoacrylate glue are presented. Although reactions to cyanoacrylate glues are considered rare, more widespread use of these products by nail salons is likely to be associated with an increased incidence of positive reactions. All 3 of our patients came into contact with...

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    authors: Belsito DV

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    doi:10.1111/j.1600-0536.1980.tb05568.x

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2012.02030.x

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    更新日期:2012-06-01 00:00:00

  • Temperature-dependent nickel release from nickel alloys.

    abstract::Nickel release from Danish one krone coins and metal buttons from jeans has been measured at 20 degrees C in distilled water and at 35 degrees C in distilled water and synthetic sweat. The temperature elevation increased the nickel release from the coins and two of the nine metal buttons investigated. Obviously the se...

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1979.tb04803.x

    authors: Menne T,Solgaard P

    更新日期:1979-03-01 00:00:00

  • Evaluation of lymphocyte transformation tests as compared with patch tests in nickel allergy diagnosis.

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    pub_type: 杂志文章

    doi:10.1111/cod.12751

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    doi:10.1111/j.1600-0536.2007.01170.x

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    更新日期:2007-08-01 00:00:00

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    更新日期:2008-04-01 00:00:00

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    更新日期:1975-10-01 00:00:00