The role of acrylic acid impurity as a sensitizing component in electrocardiogram electrodes.

Abstract:

BACKGROUND:Allergic contact dermatitis caused by (meth)acrylates is well known, both in occupational and in non-occupational settings. Contact hypersensitivity to electrocardiogram (ECG) electrodes containing (meth)acrylates is rarely reported. OBJECTIVE:To report the first case of contact dermatitis caused by acrylic acid impurity in ECG electrodes. MATERIALS AND METHODS:Patch tests were performed with separate components of electrodes and some (meth)acrylates. This was followed by high-performance liquid chromatography of electrode hydrogel. RESULTS:The patient was contact-allergic to electrode hydrogel but not to its separate constituents. Positive reactions were observed to 2-hydroxyethyl methacrylate (2-HEMA), 2-hydroxypropyl methacrylate (2-HPMA) and ethyleneglycol dimethacrylate (EGDMA). Subsequent analysis showed that the electrode hydrogel contained acrylic acid as an impurity. The latter was subsequently patch tested, with a positive result. CONCLUSION:The sensitization resulting from direct contact with ECG electrodes was caused by acrylic acid, present as an impurity in ECG electrodes. Positive reactions to 2-HEMA, 2-HPMA and EGDMA are considered to be cross-reactions.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Stingeni L,Cerulli E,Spalletti A,Mazzoli A,Rigano L,Bianchi L,Hansel K

doi

10.1111/cod.12357

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

44-8

issue

1

eissn

0105-1873

issn

1600-0536

journal_volume

73

pub_type

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