Abstract:
BACKGROUND:The evidence on the safety of topical preparations containing botanical extracts is limited. OBJECTIVES:To assess (i) the use of botanically derived compounds in a large population, (ii) the incidence of cutaneous side-effects, and (iii) the diagnostic usefulness of patch testing. METHODS:A questionnaire was used in 2661 patients to assess both the prevalence and type of topical botanical preparations used, and the occurrence of adverse skin reactions. Patients declaring adverse reactions were patch tested with (i) the Italian (SIDAPA) baseline series, (ii) an additional botanical series, and (iii) the patients' own products. RESULTS:Of the patients, 1274 (48%) reported the use of topical botanical products; 139 patients (11%) commented on adverse cutaneous reactions; 75 (54%) showed positive reactions with the Italian baseline series. Among the 122 patients tested with the botanical series, 19 (16%) showed positive reactions, in many cases with concomitant relevant positivity to at least one allergen of the Italian series connected with cosmetics. The commonest botanically derived allergens were propolis, Compositae extracts, and Melaleuca alternifolia (tea tree) oil. CONCLUSIONS:Contact allergy is a possible adverse effect of natural products. Baseline series supplemented with the commonest botanical allergens may be adequate for detecting most of the cases of contact allergy to natural topical products.
journal_name
Contact Dermatitisjournal_title
Contact dermatitisauthors
Corazza M,Borghi A,Gallo R,Schena D,Pigatto P,Lauriola MM,Guarneri F,Stingeni L,Vincenzi C,Foti C,Virgili Adoi
10.1111/cod.12124subject
Has Abstractpub_date
2014-02-01 00:00:00pages
90-7issue
2eissn
0105-1873issn
1600-0536journal_volume
70pub_type
杂志文章,多中心研究abstract::Although cinnamon is known to cause dermatitis in bakers and confectioners, it has only rarely been reported as causing trouble in food or cosmetics. A newly-formulated 'spicy' toothpaste containing cinnamon as a flavouring agent was the cause of oral symptoms in eight patients referred to clinics in Buckinghamshire a...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1975.tb05330.x
更新日期:1975-01-01 00:00:00
abstract::Deodorized kerosene in a concentration of 50 g/100 g in pet. did not cause cutaneous inflammation in 10 control guinea pigs. The proportion of 19 guinea pigs exhibiting inflammation following exposure to deodorized kerosene in the guinea pig maximization test increased, but the increase was not significant. The respon...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1983.tb04459.x
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Positive patch test reactions to mixtures of oxidized terpenes containing allergenic hydroperoxides are frequently reported. However, human sensitization data for these hydroperoxides are not available. OBJECTIVES:To analyse and evaluate the human sensitization potential and potency of hydroperoxides in vit...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.13286
更新日期:2019-08-01 00:00:00
abstract::Sensitization to olive oil is seldom reported in the literature. By use of epicutaneous tests a delayed type of hypersensitivity to pure freshly-prepared olive oil could be demonstrated in two patients. Patch tests with certain major constituents of olive oil; the methyl ester of linoleic acid, the glyceryl ester of p...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1981.tb04086.x
更新日期:1981-11-01 00:00:00
abstract::The possible interference of neighbouring allergic patch-test reactions is still an open question. In this study, we investigated whether there is a distance-related mutual modification of neighbouring allergic patch-test reactions to nickel sulfate and potassium dichromate. We used a double-blind multicentre study de...
journal_title:Contact dermatitis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1034/j.1600-0536.2000.043003144.x
更新日期:2000-09-01 00:00:00
abstract::The epidermal response to 2 different irritants, nonanoic acid (NAA) and sodium lauryl sulfate (SLS), was investigated with 2 different methods. NAA 80% and SLS 4% were applied under occlusion for up to 24 h. Elemental changes were determined in cryosections by x-ray microanalysis. Compared to unexposed skin a signifi...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1996.tb02416.x
更新日期:1996-12-01 00:00:00
abstract::A tire assembler developed contact dermatitis from IPPD, a rubber antioxidant. The lichenoid clinical pattern corresponded histologically to lichenified dermatitis. Tire assemblers appear to acquire contact dermatitis to this aromatic amine more frequently than any other workers in the tire manufacturing industry. Pos...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1982.tb04152.x
更新日期:1982-03-01 00:00:00
abstract::The aim of the study was to assess occupational hazards to the farmer's skin associated with processing thyme (Thymus vulgaris L.). 46 farmers were studied during the threshing of dried thyme. They were questioned about work-related skin problems and examined before and after work. In all persons, serum thyme-specific...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1034/j.1600-0536.2001.044004235.x
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Chromium-tanned leather footwear, which releases >3 ppm hexavalent Cr(VI), may pose a risk of sensitizing and eliciting allergic dermatitis. OBJECTIVES:To determine the content and potential release of chromium in leather footwear and to discuss the prevention of chromium contact allergy and dermatitis. ME...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2011.02053.x
更新日期:2012-05-01 00:00:00
abstract::Little is known about the prognosis of facial allergic contact dermatitis (FACD). The objective of the study was to investigate the prevalence and 1-year outcome of FACD in patients patch tested. 655 consecutive patients patch tested with European standard series in Peking University Hospital in a 2-year period were s...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2007.01198.x
更新日期:2007-09-01 00:00:00
abstract::In 1988, 64% of our patients patch test positive to at least 1 allergen of the ICDRG standard series were nickel sensitive. In 70% of 300 patients evaluated, dermatitis started on the earlobes and was related to the regular wearing of cheap earrings. At the same time, 62% of 735 young schoolgirls were found to have de...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1989.tb03203.x
更新日期:1989-10-01 00:00:00
abstract::In some patients with atopic dermatitis (AD), delayed-type allergy to aeroallergens, such as house dust mite, can be demonstrated by patch testing. Positive patch tests can be expected only in patients with AD and, in them, only to aeroallergens to which type 1 reactions have also been demonstrated. In an as yet unkno...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0536.1989.tb03197.x
更新日期:1989-10-01 00:00:00
abstract::The Nyloprint process is becoming more frequently used in Great Britain. We report a case of contact dermatitis in a 60-year-old man who was employed in the production of Nyloprint formes. The process is described in detail. Patch tests showed him to be very sensitive to an acrylamide derivative, which is used as a mo...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1976.tb03013.x
更新日期:1976-06-01 00:00:00
abstract::This report reviews how to set up a laser Doppler perfusion imaging system intended for visualization of skin blood perfusion, capture images and evaluate the results obtained. A brief summary of related papers published in the literature within the areas of skin irritant and allergy patch testing, microdialysis and s...
journal_title:Contact dermatitis
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1034/j.1600-0536.2002.460301.x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Cosensitization to nickel, cobalt and chromium occurs in the general population and in some occupational groups. OBJECTIVES:To estimate the isolated and concurrent occurrence of nickel, cobalt and chromium contact sensitization and their association with individual and occupational risk factors. PATIENTS/M...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2012.02100.x
更新日期:2012-12-01 00:00:00
abstract::202 patients, 68 males and 134 females, with patch-test-negative, symmetrical vesicular hand eczema were challenged orally in a controlled study with 2.5 mg nickel, 2.5 mg chromium and 1 mg cobalt given as salts of the respective metals. Initially a mixture of the 3 metal salts was given, and if this produced a flare ...
journal_title:Contact dermatitis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0536.1983.tb04437.x
更新日期:1983-09-01 00:00:00
abstract::As one step in defining the clinical relevance of exposure to an allergen identified with patch testing, use tests (provocative use test (PUT), and repeated open application test (ROAT)) have been used. In 1/2 of the cases of seemingly reliable patch tests, use tests are negative, suggesting that the patient's biologi...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0536.2000.043001001.x
更新日期:2000-07-01 00:00:00
abstract::Nickel-elicited systemic contact dermatitis is a well-known entity, although it is far less common than allergic contact dermatitis. In most of the cases, the main way of nickel administration is oral. Clinical manifestations are miscellaneous including pompholyx, diffuse exanthema, flexural dermatitis or baboon syndr...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.0105-1873.2005.00689.x
更新日期:2005-10-01 00:00:00
abstract::This review summarizes published and unpublished data of our 15-year experience with sunscreen allergy and photoallergy. From 1981-1996, 402 patients with suspected clinical photosensitivity were patch and photopatch tested with the commercial sunscreens and facial cosmetics that they had used and with chemical UV abs...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0536.1997.tb02439.x
更新日期:1997-11-01 00:00:00
abstract::Patch-test technique for budesonide needs improvement. 20 subjects with positive or questionable patch-test responses to budesonide were retested for 3 to 96 h (4 days [D]) with polyester patches coated with budesonide in serial doses (150 to 0.074 microg/cm2). Multiple readings were taken visually and with a laser Do...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1999.tb06132.x
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Chromium is an important skin sensitizer. Exposure to it has been regulated in cement, and recently in leather. Studies on the deposition of chromium ions on the skin as a result of handling different chromium-containing materials are sparse, but could improve the risk assessment of contact sensitization and...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12605
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Chromium-tanned leather articles currently constitute the most important cause of contact allergy to chromium in Denmark. A regulation on the content of hexavalent chromium in leather was adopted in November 2013 by the EU member states. OBJECTIVES:To characterize patients with chromium allergy and their di...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12291
更新日期:2014-12-01 00:00:00
abstract::Piroxicam (PXM) is a nonsteroidal anti-inflammatory drug which may induce a photosensitive eruption shortly after administration. We examined whether animals sensitized to thimerosal developed a photosensitivity to PXM. Male Hartley strain guinea pigs were sensitized to thimerosal, thiosalicylate and PXM separately. T...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1991.tb01769.x
更新日期:1991-07-01 00:00:00
abstract::The purpose of the present study was to compare the frequency of lanolin allergy during two periods and to assess the adequacy of testing with one standard allergen. Among 1230 consecutive patients with eczema who were standard patch tested, 33 (2.7%), 21 females and 12 males, gave a positive reaction to wool alcohols...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1979.tb04824.x
更新日期:1979-05-01 00:00:00
abstract::An experimental study is reported of the irritant potential of oil of purcellin , isopropyl palmitate, nonyl phenol, Modulan , Amerchol and Acetulan when massaged in fixed amounts into the rabbit's skin daily for 30 days. Skin biopsies provided data on the number of epithelial cell layers, cell counts of the superfici...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1984.tb00102.x
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Lanolin has been tested as lanolin alcohols (30% pet.) in baseline patch test series since 1969, and this has shown clinically relevant allergic contact dermatitis cases. OBJECTIVES:To investigate the temporal development of lanolin allergy (i.e. positive reaction to lanolin alcohols and/or Amerchol™ L-101)...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12872
更新日期:2018-01-01 00:00:00
abstract::Metallic aluminium and methylene blue applied to human skin interact and give a strong resistant coloration, obtained neither with methylene blue itself nor with other dyes. The reaction proves that aluminium is not an inert material and that the aluminium in Finn chambers can be expected to interact with other patch ...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1985.tb01031.x
更新日期:1985-01-01 00:00:00
abstract::Copolymers or heteropolymers are large molecules with high molecular weights (>1000 D). They have been underestimated for a long time as to their sensitizing capacities. Allergic contact dermatitis to 6 copolymers in cosmetics and 1 in a medical dressing has been described; however, the nature of the hapten is still u...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0536.2006.00960.x
更新日期:2006-11-01 00:00:00
abstract::Nickel release from Danish one krone coins and metal buttons from jeans has been measured at 20 degrees C in distilled water and at 35 degrees C in distilled water and synthetic sweat. The temperature elevation increased the nickel release from the coins and two of the nine metal buttons investigated. Obviously the se...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1979.tb04803.x
更新日期:1979-03-01 00:00:00
abstract::Sixty-six patients who had to undergo total hip replacement by means of a metal-to-plastic Stanmore prosthesis, were patch-tested prior to and 6 to 12 months after surgery with the standard ICDRG all allergens series and with acrylic monomer 5% in acetone. In 62 patients the history of metal allergy as well as the pat...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1976.tb03044.x
更新日期:1976-10-01 00:00:00