Abstract:
:Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 deodorants was performed for identification of fragrance and non-fragrance materials present in marketed deodorants. Futhermore, the sensitizing potential of these molecules was evaluated using structure activity relationships (SARs) analysis. This was based on the presence of 1 or more chemically reactive site(s), in the chemical structure, associated with sensitizing potential. Among the many different substances used to formulate cosmetic products (over 3500), 226 chemicals were identified in a sample of 71 deodorants. 84 molecules were found to contain at least 1 structural alert, and 70 to belong to, or be susceptible to being metabolized into, the chemical group of aldehydes, ketones and alpha,beta-unsaturated aldehydes, ketone or esters. The combination of GC-MS and SARs analysis could be helpful in the selection of substances for supplementary investigations regarding sensitizing properties. Thus, it may be a valuable tool in the management of contact allergy to deodorants and for producing new deodorants with decreased propensity to cause contact allergy.
journal_name
Contact Dermatitisjournal_title
Contact dermatitisauthors
Rastogi SC,Lepoittevin JP,Johansen JD,Frosch PJ,Menné T,Bruze M,Dreier B,Andersen KE,White IRdoi
10.1111/j.1600-0536.1998.tb05944.xsubject
Has Abstractpub_date
1998-12-01 00:00:00pages
293-303issue
6eissn
0105-1873issn
1600-0536journal_volume
39pub_type
杂志文章abstract::We showed earlier that most patients with contact dermatitis due to corticosteroids show cross-reactions when patch tested with hydrocortisone-17-butyrate (H-17-B). To test whether H-17-B could be used for detecting topical corticosteroid allergy, we screened patients undergoing routine patch testing with H-17-B. Pati...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1989.tb04729.x
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Occupational skin diseases (OSDs) often have considerable medical and occupational consequences. Previous data on prognostic factors have been derived from studies with fairly small sample sizes. OBJECTIVES:To determine the medical and occupational outcome in 1048 patients diagnosed with OSD at the Finnish ...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2009.01611.x
更新日期:2009-11-01 00:00:00
abstract::A cohort of initially 111 office apprentices was prospectively followed for the duration of their training (2 and 3 years, respectively). The point prevalence of (slight) irritant or atopic hand eczema was 18.9% in the initial and 25.0% in the final examinations. Altogether, 37 cases of (slight) hand eczema were noted...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:The use of permanent hair dyes exposes hairdressers to contact allergens such as p-phenylenediamine (PPD), and the preventive measures are insufficient. OBJECTIVES:To perform an in vivo test to study the protective effect of gloves commonly used by hairdressers. PATIENTS/MATERIALS/METHODS:Six gloves from S...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12320
更新日期:2015-04-01 00:00:00
abstract::In cases of conjunctivitis associated with the use of soft lenses, delayed hypersensitivity to disinfecting components of the used soft lens liquids has to be considered. In 7/15 patients, positive patch test reactions to merthiolate, chlorhexidine or the soaking solutions were observed. The significance of these find...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1980.tb04956.x
更新日期:1980-08-01 00:00:00
abstract::Pimecrolimus suppresses the proinflammatory cytokine production of cutaneous T and mast cells (1). It is used to treat atopic dermatitis and is the active ingredient in the topical formulation pimecrolimus 1.0% cream (Elidel, Novartis Pharma AG, Basel, Switzerland). ...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2007.00822.x
更新日期:2007-01-01 00:00:00
abstract::Allergic contact dermatitis caused by medical devices for diabetes patients has been increasingly described in the literature in the last few years. This article reviews the cases of allergic contact dermatitis caused by insulin pumps and glucose sensors reported since the 1970s, the culprit allergen(s), the results o...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/cod.13120
更新日期:2018-12-01 00:00:00
abstract::Occupational skin disease is one of the most common occupational diseases. The hand is the most frequent site of involvement in occupational skin disease. We interviewed and examined patients seen in the Contact Dermatitis Clinic of the National Taiwan University Medical Center, a tertiary referral center in Taipei Ci...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1995.tb02077.x
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial products, and the first cases of isolat...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2010.01774.x
更新日期:2010-09-01 00:00:00
abstract::Rubber chemicals are among the most common occupational contact sensitizers. The most common rubber sensitizers are thiurams, thiazoles, carbamates and paraphenylenediamine derivatives. Here we present data on a less-well-known rubber chemical, N-(cyclohexylthio)phthalimide (CTP; CAS 17796-82-6). This chemical is curr...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1996.tb02106.x
更新日期:1996-01-01 00:00:00
abstract::Allergens used for patch testing in the hairdressing series vary between dermatology centres in the UK. The aim of our study is to ascertain the hairdressing allergens currently in use and their test results in several dermatology centres in the UK. Data were obtained from databases in 9 dermatology departments. The a...
journal_title:Contact dermatitis
pub_type: 杂志文章,多中心研究
doi:10.1111/j.0105-1873.2005.00661.x
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The prognosis of occupational hand eczema is strongly associated with its duration, severity, and the onset of treatment. OBJECTIVES:The study was aimed at characterizing skin eruptions that might be potential precursors of occupational hand eczema, their pattern, and typical sites in a population at modera...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2011.01969.x
更新日期:2012-02-01 00:00:00
abstract::To investigate the mechanisms of non-immunologic contact urticaria (NICU), the effect of 120 mg of terfenadine (H1-antagonist) on contact reactions to methyl nicotinate, diethyl fumarate, benzoic acid, cinnamic acid, cinnamic aldehyde and dimethyl sulfoxide was studied in 20 subjects. Erythema and edema were observed ...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1987.tb01429.x
更新日期:1987-04-01 00:00:00
abstract::Between January 1993 and February 2002, 40 of 1354 (3%) workers who attended a tertiary referral occupational dermatology clinic were diagnosed with allergic contact dermatitis (ACD) from epoxy resin systems (ER). 20 of these patients were followed up at least 2 years post-diagnosis to establish prognosis. Characteris...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.0105-1873.2005.00542.x
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin (PTBP-FR) included in most baseline patch test series. OBJECTIVES:To investigate the rate of contact allergy to PFR-2 (a mixture of monomers and dimers from a ...
journal_title:Contact dermatitis
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1600-0536.2011.01921.x
更新日期:2011-07-01 00:00:00
abstract::The authors followed the frequency of fragrance contact sensitization in Hungary in a multicentre study in the years 1998 and 1999. A total of 3,604 patients were tested with fragrance mix (FM), and positive reactions were observed in 294 (8.2%). In 160 FM hypersensitive patients, the study was continued with patch te...
journal_title:Contact dermatitis
pub_type: 杂志文章,多中心研究
doi:10.1034/j.1600-0536.2002.460602.x
更新日期:2002-06-01 00:00:00
abstract::Murine models for the assessment of the contact sensitizing properties of chemicals rely on mouse ear swelling tests (Mest), which are not sensitive enough to detect weak sensitizers. The aim of the present study was to develop in mice an adjuvant-free Mest appropriate for in vivo detection of any type of sensitizer (...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1994.tb00650.x
更新日期:1994-04-01 00:00:00
abstract::The usefulness of a trivalent gold salt, gold trichloride (GTC), was evaluated as a marker of contact allergy to gold. Patients patch test-positive or patch test-negative to gold sodium thiosulfate (GSTS), 13 subjects of each, were patch tested with dilution series of GTC and equimolar concentrations of GSTS. In order...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.0105-1873.2005.00648.x
更新日期:2005-08-01 00:00:00
abstract::Hand dermatitis is a prevalent disease with an episodic, chronic character. The use of medical resources is high and is often related to reduced (work) functioning. The burden is therefore high for patients and society. Management of hand dermatitis is often unsatisfactory, and for this reason prevention is important....
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0536.2010.01825.x
更新日期:2011-02-01 00:00:00
abstract::The sensitization capacity of ethylenediamine was examined by the guinea pig maximization test and compared with dinitrochlorobenzene. Ethylenediamine was found to be a potent sensitizer. An attempt at oral induction of unresponsiveness (tolerance) was unsuccessful with ethylenediamine and DNCB and the same negative r...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1979.tb04881.x
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:The bark of the cinnamon tree is used as a spice; its flavour is from an essential oil containing mainly cinnamal. OBJECTIVE:To report new cases of occupational allergic contact dermatitis (ACD) from cinnamon and a novel case of airborne cinnamon contact allergy. METHODS:We examined the patient material of...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2008.01486.x
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules. OBJECTIVES:To investigate if...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2008.01474.x
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Reviews on irritant and allergic airborne contact dermatitis have been previously reported in the literature. MATERIALS AND METHODS:Here, we present an update based on recently published airborne-induced skin reactions. For this survey, we screened the journals Contact Dermatitis, Dermatitis, and included r...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/cod.12022
更新日期:2013-04-01 00:00:00
abstract::In a plant producing advanced components for engines and drivelines we undertook a survey of occupational dermatoses, based on a questionnaire, clinical examination, and patch testing with a standard series and a series of samples from the working environment. The questionnaire was given to all 430 employees and it wa...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1034/j.1600-0536.2003.480205.x
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:An acute viral cold is a very common illness and is characterized by sneezing and a runny nose. Because of rhinorrhea and frequent use of handkerchiefs, the skin around the nose feels uncomfortably dry and flaky. OBJECTIVES/METHODS:To evaluate the nasolabial skin barrier impairment, 14 female volunteers wit...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2008.01425.x
更新日期:2008-11-01 00:00:00
abstract::The expression of surface-bound immunoglobulin E by dendritic cells within cutaneous tissue has been compared in atopic and contact dermatitis. 45 patients were recruited into 4 groups using clinical criteria and patch testing to a standard series of allergens: atopic (12 cases), allergic contact dermatitis (14 cases)...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1991.tb01799.x
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:The presence of hexavalent chromium (Cr[VI]), which is carcinogenic to humans and a dermal sensitizer, in tattoo inks may represent a serious health concern. The level of this impurity is limited to 0.2 mg/kg in tattoo inks by the European Resolution ResAP(2008)1. OBJECTIVES:To analyse 29 tattoo inks, produ...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.13051
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Contact allergy to epoxy (meth)acrylates, 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]propane (bis-GMA), 2,2-bis[4-(2-hydroxy-3-acryloxypropoxy)phenyl]-propane (bis-GA), 2,2-bis[4-(methacryl-oxyethoxy)phenyl] propane (bis-EMA), 2,2-bis[4-(methacryloxy)phenyl]-propane (bis-MA), and glycidyl methacrylat...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2009.01574.x
更新日期:2009-07-01 00:00:00
abstract::Skin compatibility of anionic surfactants may often but not always be predicted by in vitro tests. For instance, the correlation between in vivo and in vitro data is classically hampered in the presence of magnesium. This ion is known to interfere with in vitro skin irritation predictive tests based on protein denatur...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1995.tb00445.x
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Primin is the main contact allergen found in the ornamental plant Primula obconica Hance. OBJECTIVE:To analyse the temporal trend of sensitivity to primin in north-eastern Italy and to evaluate the associations with occupations in our geographical area. METHODOLOGY:From 1996 to 2012, 24 052 consecutive pat...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12385
更新日期:2015-08-01 00:00:00