There is an association between contact allergy to aluminium and persistent subcutaneous nodules in children undergoing hyposensitization therapy.

Abstract:

BACKGROUND:The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules. OBJECTIVES:To investigate if hyposensitization therapy can induce contact allergy to aluminium and examine if there is any association between persistent subcutaneous nodules and aluminium allergy. PATIENTS/METHODS:Sixty-one children with allergic asthma and/or allergic rhinitis participated in the study of whom 37 had had hyposensitization therapy. The study consisted of a non-clinical part based on a questionnaire and a clinical part with a physical examination, self-assessment of itching, and patch testing. To secure an unbiased evaluation of possible reactions, the investigators were blinded. RESULTS:Contact allergy to aluminium was found in eight participants, all in the exposed group (8/37 versus 0/24, P = 0.02). Examination showed nodules on the upper arms in 13 participants, all in the group exposed to hyposensitization therapy. Nodules were over-represented in patients with contact allergy to aluminium. CONCLUSIONS:There was a statistically significant association between contact allergy to aluminium and persistent subcutaneous nodules in children who had had hyposensitization therapy.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Netterlid E,Hindsén M,Björk J,Ekqvist S,Güner N,Henricson KA,Bruze M

doi

10.1111/j.1600-0536.2008.01474.x

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

41-9

issue

1

eissn

0105-1873

issn

1600-0536

pii

COD1474

journal_volume

60

pub_type

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