Hexavalent chromium in tattoo inks: Dermal exposure and systemic risk.

Abstract:

BACKGROUND:The presence of hexavalent chromium (Cr[VI]), which is carcinogenic to humans and a dermal sensitizer, in tattoo inks may represent a serious health concern. The level of this impurity is limited to 0.2 mg/kg in tattoo inks by the European Resolution ResAP(2008)1. OBJECTIVES:To analyse 29 tattoo inks, produced in Europe and the United States, of different colours and brands, for Cr(VI) to assess their conformity with ResAP(2008)1 and to characterize dermal and systemic risks. METHODS:Ion chromatography and inductively coupled plasma mass spectrometry were used to determine the levels of Cr(VI) in inks; risk characterization was performed by calculating the systemic exposure dosage (SED) and margin of safety (MoS). RESULTS:Ninety per cent of inks contained Cr(VI) (range: 0.22-4.09 mg/kg), ie, above the maximum allowed level, and no information appeared on the label. More than 1 mg/kg Cr(VI) was detected in 27.6% of inks; these might represent a possible cause of dermal adverse reactions. Exposure to Cr(VI) in inks resulted in negligible SED values and MoS values of >100 (safety threshold), indicating no appreciable systemic risk. CONCLUSIONS:The minimization of Cr(VI) contamination and the use of technology compliant with good manufacturing practices is recommended to increase the safety of tattoo inks.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Bocca B,Senofonte O,Petrucci F

doi

10.1111/cod.13051

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

218-225

issue

4

eissn

0105-1873

issn

1600-0536

journal_volume

79

pub_type

杂志文章
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    abstract::In some patients with atopic dermatitis (AD), delayed-type allergy to aeroallergens, such as house dust mite, can be demonstrated by patch testing. Positive patch tests can be expected only in patients with AD and, in them, only to aeroallergens to which type 1 reactions have also been demonstrated. In an as yet unkno...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1989.tb03197.x

    authors: de Groot AC,Young E

    更新日期:1989-10-01 00:00:00

  • Patch test reactions in atopic patients.

    abstract::Patch testing was carried out in 851 atopic patients; 181 atopic dermatitis (AD) patients were additionally tested with 50% dilutions of the test substances. The occurrence of allergic and irritant reactions was frequent, being 57% and 33% for AD patients aged 28-41 years and 19-27 years, respectively. Among age-match...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1992.tb00235.x

    authors: Lammintausta K,Kalimo K,Fagerlund VL

    更新日期:1992-04-01 00:00:00

  • The development of metal hypersensitivity in patients with metal-to-plastic hip arthroplasties.

    abstract::Sixty-six patients who had to undergo total hip replacement by means of a metal-to-plastic Stanmore prosthesis, were patch-tested prior to and 6 to 12 months after surgery with the standard ICDRG all allergens series and with acrylic monomer 5% in acetone. In 62 patients the history of metal allergy as well as the pat...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1976.tb03044.x

    authors: Nater JP,Brain RG,Deutman R,Mulder TJ

    更新日期:1976-10-01 00:00:00

  • Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines.

    abstract:BACKGROUND:Corticosteroids (CS), anti-inflammatory drugs also widely used to treat various allergic diseases, may themselves give rise to immediate and delayed allergic hypersensitivity reactions. OBJECTIVES:To realise an appropriate diagnostic work-up in order to determine the CS-allergic patient's sensitization/tole...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2011.01967.x

    authors: Baeck M,Goossens A

    更新日期:2012-01-01 00:00:00

  • The MOAHLFA index of irritant sodium lauryl sulfate reactions: first results of a multicentre study on routine sodium lauryl sulfate patch testing.

    abstract::In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25% and 0.5% aq. has been added to routine allergen patch tests to assess its properties as a convenient diagnostic indicator of individual susceptibility to irritation at the time of patch testing. Previous studies i...

    journal_title:Contact dermatitis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.0105-1873.2004.00458.x

    authors: Uter W,Geier J,Becker D,Brasch J,Löffler H

    更新日期:2004-11-01 00:00:00

  • Contact allergenic activity of Tween 80 before and after air exposure.

    abstract::Tween 80 is an ethoxylated hydrophilic non-ionic surfactant, which is used for the preparation of oil-in-water emulsions in pharmaceutical products, cosmetics, and industrial detergents. Ethoxylated surfactants are polyethers and are thus easily oxidized by atmospheric oxygen to a variety of hydroperoxides, peroxides ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1997.tb00368.x

    authors: Bergh M,Magnusson K,Nilsson JL,Karlberg AT

    更新日期:1997-07-01 00:00:00

  • Quantitative risk assessment for the induction of allergic contact dermatitis: uncertainty factors for mucosal exposures.

    abstract::The quantitative risk assessment (QRA) paradigm has been extended to evaluating the risk of induction of allergic contact dermatitis from consumer products. Sensitization QRA compares product-related, topical exposures to a safe benchmark, the sensitization reference dose. The latter is based on an experimentally or c...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.0105-1873.2003.00192.x

    authors: Farage MA,Bjerke DL,Mahony C,Blackburn KL,Gerberick GF

    更新日期:2003-09-01 00:00:00

  • Fragrances and other materials in deodorants: search for potentially sensitizing molecules using combined GC-MS and structure activity relationship (SAR) analysis.

    abstract::Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 deodorants was performed for identification of fragrance and non-fragrance materials present in marketed deodorants. Futhermore, the sen...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1998.tb05944.x

    authors: Rastogi SC,Lepoittevin JP,Johansen JD,Frosch PJ,Menné T,Bruze M,Dreier B,Andersen KE,White IR

    更新日期:1998-12-01 00:00:00

  • Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers.

    abstract::Murine models for the assessment of the contact sensitizing properties of chemicals rely on mouse ear swelling tests (Mest), which are not sensitive enough to detect weak sensitizers. The aim of the present study was to develop in mice an adjuvant-free Mest appropriate for in vivo detection of any type of sensitizer (...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1994.tb00650.x

    authors: Garrigue JL,Nicolas JF,Fraginals R,Benezra C,Bour H,Schmitt D

    更新日期:1994-04-01 00:00:00

  • Patch test reactions to metal salts in patients with oral mucosal lesions associated with amalgam restorations.

    abstract::Patch testing with various metal salts was performed in patients with oral mucosal lesions associated with amalgam restorations, by using polypropylene-coated aluminium discs. Positive reactions to mercuric chloride were obtained in 5/12 (42%) of these patients, but only in 1/11 patients (9%) with oral mucosal lesions...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1992.tb05245.x

    authors: Nordlind K,Lidén S

    更新日期:1992-09-01 00:00:00

  • The role of acrylic acid impurity as a sensitizing component in electrocardiogram electrodes.

    abstract:BACKGROUND:Allergic contact dermatitis caused by (meth)acrylates is well known, both in occupational and in non-occupational settings. Contact hypersensitivity to electrocardiogram (ECG) electrodes containing (meth)acrylates is rarely reported. OBJECTIVE:To report the first case of contact dermatitis caused by acrylic...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12357

    authors: Stingeni L,Cerulli E,Spalletti A,Mazzoli A,Rigano L,Bianchi L,Hansel K

    更新日期:2015-07-01 00:00:00

  • Sodium metabisulfite--a marker for cosmetic allergy?

    abstract::A 45-year-old woman developed dermatitis of the face after she applied a cosmetic package comprising day and night creams. Patch tests were performed with the British Contact Dermatitis Society (BCDS) standard, bases + preservatives, and cosmetic series in addition to samples of both creams and the individual constitu...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2007.00972.x

    authors: Malik MM,Hegarty MA,Bourke JF

    更新日期:2007-04-01 00:00:00

  • A clinical and patch test study of patients with positive patch test reactions to fragrance mix in China.

    abstract::The clinical and patch test (PT) features of patients with positive PT reactions to fragrance mix (FM) were studied. 378 consecutive eczema outpatients patch tested with a modified European standard series were analysed. 60 patients (15.9%) reacted to FM. No significant differences could be found between the ages of F...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.0105-1873.2005.00516.x

    authors: Lu X,Li LF,Wang W,Wang J

    更新日期:2005-04-01 00:00:00

  • Patch test results with rubber series in the European Surveillance System on Contact Allergies (ESSCA), 2013/14.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12651

    authors: Uter W,Warburton K,Weisshaar E,Simon D,Ballmer-Weber B,Mahler V,Fuchs T,Geier J,Wilkinson M

    更新日期:2016-12-01 00:00:00

  • Allergy to lanolin.

    abstract::The purpose of the present study was to compare the frequency of lanolin allergy during two periods and to assess the adequacy of testing with one standard allergen. Among 1230 consecutive patients with eczema who were standard patch tested, 33 (2.7%), 21 females and 12 males, gave a positive reaction to wool alcohols...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1979.tb04824.x

    authors: Mortensen T

    更新日期:1979-05-01 00:00:00

  • An update on airborne contact dermatitis: 2007-2011.

    abstract:BACKGROUND:Reviews on irritant and allergic airborne contact dermatitis have been previously reported in the literature. MATERIALS AND METHODS:Here, we present an update based on recently published airborne-induced skin reactions. For this survey, we screened the journals Contact Dermatitis, Dermatitis, and included r...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/cod.12022

    authors: Swinnen I,Goossens A

    更新日期:2013-04-01 00:00:00

  • Generalized eruption with severe liver dysfunction associated with occupational exposure to trichloroethylene.

    abstract::Generalized dermatitis due to trichloroethylene is rare. A 21-year-old printer developed exfoliative dermatitis with mucous membrane involvement, fever and liver dysfunction after a 2-week occupational exposure to trichloroethylene. Positive patch-test reactions to trichloroethylene and to one of its metabolites, tric...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1988.tb02867.x

    authors: Nakayama H,Kobayashi M,Takahashi M,Ageishi Y,Takano T

    更新日期:1988-07-01 00:00:00

  • Efficacy of skin barrier creams (II). Ineffectiveness of a popular "skin protector" against various irritants in the repetitive irritation test in the guinea pig.

    abstract::A popular "skin protector" consisting of an emulsion-like foam of lipophilic and hydrophilic substances (Marly skin) was evaluated in a previously described repetitive irritation guinea pig model. The product failed to inhibit the irritation due to sodium lauryl sulphate and toluene. In striking contrast to the recomm...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1993.tb03486.x

    authors: Frosch PJ,Schulze-Dirks A,Hoffmann M,Axthelm I

    更新日期:1993-08-01 00:00:00

  • Self-reported skin disease in hydrotherapists working in swimming pools.

    abstract::The aim of our study was to investigate the risk and characteristics of self-reported skin diseases among hydrotherapists. We attempted to contact 400 adults who participated in 1 of 2 training courses. 248 were reached and 190 of them (76.6%) completed the questionnaires. The data were collected by means of a telepho...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.0105-1873.2005.00699.x

    authors: Lazarov A,Nevo K,Pardo A,Froom P

    更新日期:2005-12-01 00:00:00

  • Oral challenge with metal salts. (I). Vesicular patch-test-negative hand eczema.

    abstract::202 patients, 68 males and 134 females, with patch-test-negative, symmetrical vesicular hand eczema were challenged orally in a controlled study with 2.5 mg nickel, 2.5 mg chromium and 1 mg cobalt given as salts of the respective metals. Initially a mixture of the 3 metal salts was given, and if this produced a flare ...

    journal_title:Contact dermatitis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0536.1983.tb04437.x

    authors: Veien NK,Hattel T,Justesen O,Nørholm A

    更新日期:1983-09-01 00:00:00

  • Primary irritant dermatitis from topical clioquinol.

    abstract::During the 2-year period 1976--1977, seven patients were studied with primary irritant dermatitis from topical preparations containing clioquinol. During the same period contact hypersensitivity to the compound was recorded in 35 eczema patients. Six of the seven patients with clioquinol irritancy had used creams cont...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1979.tb04810.x

    authors: Kero M,Hannuksela M,Sothman A

    更新日期:1979-03-01 00:00:00

  • The influence of patch test size and design on the distribution of erythema induced by sodium lauryl sulfate.

    abstract::Patch testing is an invaluable tool for the experimental induction of acute irritant contact dermatitis (ICD), with a variety of chamber systems available for use. Ideally, the inflammatory reactions produced should be of uniform intensity across the test area, thereby facilitating grading of the response and tissue s...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1999.tb06158.x

    authors: Nicholson M,Willis CM

    更新日期:1999-11-01 00:00:00

  • Occupational dermatoses in a metalworking plant.

    abstract::In a plant producing advanced components for engines and drivelines we undertook a survey of occupational dermatoses, based on a questionnaire, clinical examination, and patch testing with a standard series and a series of samples from the working environment. The questionnaire was given to all 430 employees and it wa...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1034/j.1600-0536.2003.480205.x

    authors: Gruvberger B,Isaksson M,Frick M,Pontén A,Bruze M

    更新日期:2003-02-01 00:00:00

  • Different pathways in irritant contact eczema? Early differences in the epidermal elemental content and expression of cytokines after application of 2 different irritants.

    abstract::The epidermal response to 2 different irritants, nonanoic acid (NAA) and sodium lauryl sulfate (SLS), was investigated with 2 different methods. NAA 80% and SLS 4% were applied under occlusion for up to 24 h. Elemental changes were determined in cryosections by x-ray microanalysis. Compared to unexposed skin a signifi...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1996.tb02416.x

    authors: Grängsjö A,Leijon-Kuligowski A,Törmä H,Roomans GM,Lindberg M

    更新日期:1996-12-01 00:00:00

  • An epidemic of allergic contact dermatitis caused by a new allergen, caprylhydroxamic acid, in moisturizers.

    abstract:BACKGROUND:In 2016, dermatologists in Finland suspected contact allergy in several patients using moisturizers under the trade name Apobase®. Following a formulation change, Phenostat™, which is a mixture of phenoxyethanol, caprylhydroxamic acid, and methylpropanediol, was used as a preservative in Apobase® moisturizer...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12787

    authors: Ackermann L,Virtanen H,Korhonen L,Laukkanen A,Huilaja L,Riekki R,Hasan T

    更新日期:2017-09-01 00:00:00

  • Contact allergy due to colophony. (V). Patch test results with different types of colophony and modified-colophony products.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1989.tb03149.x

    authors: Hausen BM,Mohnert J

    更新日期:1989-04-01 00:00:00

  • Occupational airborne contact dermatitis caused by thyme dust.

    abstract::The aim of the study was to assess occupational hazards to the farmer's skin associated with processing thyme (Thymus vulgaris L.). 46 farmers were studied during the threshing of dried thyme. They were questioned about work-related skin problems and examined before and after work. In all persons, serum thyme-specific...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1034/j.1600-0536.2001.044004235.x

    authors: Spiewak R,Skorska C,Dutkiewicz J

    更新日期:2001-04-01 00:00:00

  • Allergic contact dermatitis to copolymers in cosmetics--case report and review of the literature.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.2006.00960.x

    authors: Quartier S,Garmyn M,Becart S,Goossens A

    更新日期:2006-11-01 00:00:00

  • Contact dermatitis due to Nyloprint.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1976.tb03013.x

    authors: Pye RJ,Peachey RD

    更新日期:1976-06-01 00:00:00

  • The effect of the guinea pig maximization protocol on the irritant response to deodorized kerosene - the excited skin syndrome.

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    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1983.tb04459.x

    authors: Nethercott JR,Lawrence M

    更新日期:1983-11-01 00:00:00